BioTechScope

Communicating key breakthroughs in synthetic & digital biology across healthcare & translational research.

[BioTechScope @BioTechScope1]

Biohijacking Listeria to deliver tetanus protein to aggressive ‘cold’ pancreatic cancer tumours, which elicits immune response in tetanus vaccinated individuals.
#drugdelivery #cancer #livingmedicines #biotherapeutics #syntheticbiology @EinsteinMed

https://t.co/gycJ1wdeXz

[BioTechScope @BioTechScope1]

A programmable microbial ‘cloak’ enhances delivery & temporarily evades immunity, improving anti-tumour efficacy & reducing toxicity of therapeutic bacteria.
#celldelivery #drugdelivery #drugdevelopment #cancer #livingmedicines #biotherapeutics @Columbia

https://t.co/DM8qWgkwIS

[BioTechScope @BioTechScope1]

A reduced-size in vivo prime editor corrects phenylketonuria disease-causing mutations at therapeutic levels. #primeeditor #primeediting #geneediting #genomeengineering #crispr @UZH_en
https://t.co/x3nP5vIpHO

[BioTechScope @BioTechScope1]

Stabilising the tumour suppressor p53 with spider silk increases expression, adopts compact state & kills cancer cells, unlocking new cancer therapy approaches. #cancerresearch #tumoursuppressors #biomedical #tumourbiology #syntheticbiology @karolinskainst
https://t.co/4N69I6U5GE

[BioTechScope @BioTechScope1]

A Phase II clinical trial shows a cellular therapy is the first to lead to meaningful functional improvement in heart & muscle in the most severe cases of Duchenne muscular dystrophy
#cellulartherapy #celltherapy #duchenne #clinicaltrials @UCDavisHealth

https://t.co/01bMWdZ85k

[BioTechScope @BioTechScope1]

Follicle-stimulating hormone (FSH) is a major pathogenic factor in Alzheimer’s in menopausal women, & FSH blockade improves cognition & pathology, opening new avenues for treatment.
#alzheimersdisease #neurodegenerativedisease #translationalresearch
https://t.co/y3hyxJzS2p

[BioTechScope @BioTechScope1]

Clinically translatable cytokine factory implants produce natural cytokines and can eradicate peritoneal tumours in as little as six days. #cytokines #cancerresearch #celltherapy #cytokinetherapy #IL2 #bioengineering #immunotherapy @RiceUniversity

https://t.co/pwFG5LkqGD

[BioTechScope @BioTechScope1]

FluoPEER is a new customisable tool to screen optimal prime editing conditions, enrich genomic editing and repair disease-causing mutation in patient cells. #crispr #dna #geneticengineering #molecularmedicine #targetedgenerepair #primeediting @UMCU_Intl
https://t.co/J87gHCwj78

[BioTechScope @BioTechScope1]

One-time gene replacement therapy enables transfusion-dependent β-thalassemia adults and children to become transfusion free. #genetherapy #thalassemia #cancer #geneediting #cancerresearch @bluebirdbio
https://t.co/2PaOU7Ne4q

[BioTechScope @BioTechScope1]

Enzymes remove blood type antigens from humans cells to create universal donor organs for transplant, in efforts to alleviate organ crisis. #organs #transplant #antigens #universalorgans #immunesystem #immunerejection @UHNTransplant
https://t.co/CCVLQ3wn7W

[BioTechScope @BioTechScope1]

The first fully autonomous biohybrid fish propelled by human heart cells is an exciting step towards building an artificial heart.
#bioengineering #biohybrid #syntheticbiology #cardiovasculardisease #artificialorgans #health @Harvard

https://t.co/Vo4NkdfzQh

[BioTechScope @BioTechScope1]

New paired CRISPRa & CRISPRi platform decodes the genetic programs regulating stimulation-responsive cytokine production in human T cells.
#crispr #crispra #tcells #geneediting #immunesystem #cytokines #cancer @GladstoneInst

https://t.co/uYVj37wlA5

[BioTechScope @BioTechScope1]

Testing mutations in three autism risk genes in brain organoids reveals convergence on asynchronous neuron development, but through distinct pathways, opening new avenues for treatment
#organoids #syntheticbiology #autism #genomeediting @broadinstitute

https://t.co/x4CHZ5MX9D

[BioTechScope @BioTechScope1]

@synbio_tech It is an incredible achievement, changing peoples lives!

[BioTechScope @BioTechScope1]

New microswimmers can steer through biological fluids and blood, propelled at high speed by light, and deliver therapeutic cargo on-demand. #nanoparticles #drugdelivery #microswimmer #biomedicine

https://t.co/BlSgiZcfEG

[BioTechScope @BioTechScope1]

The world’s first clinical-grade transplant of gene-edited pig kidneys into a brain-dead human recipient, successfully functioned for days & avoided rejection.
#organtransplant #kidneydisease #geneticengineering #geneediting #syntheticbiology @UABNews

https://t.co/FUsGvZbkHo

[BioTechScope @BioTechScope1]

The UK's first AI-driven bionic vision device implanted into age-related macular degeneration (AMD) patient restores visual acuity in blind eye. #bionic #artificialinteeligence #ai #medicaldevice #digitalbiology #dryAMD @Moorfields @PixiumVision

https://t.co/Ihu2R3MtFF

[BioTechScope @BioTechScope1]

New ultra-rapid genome sequencing approach diagnoses rare genetic diseases in under 8 hours, & sets a world record for fastest DNA sequencing technique. #dnasequencing #dna #genomesequencing #genome #diagnostic #geneticdisease @StanfordMed @nanopore
https://t.co/1Ojms1tP1N

[BioTechScope @BioTechScope1]

Engineered DNA-free virus-like particles (eVLPs) efficiently package & deliver base editor or Cas9 ribonucleoproteins in vivo with therapeutically relevant efficiencies. #baseeditors #crispr #geneediting #geneticdisease #drugdelivery @broadinstitute
https://t.co/IMIWdofnGs

[BioTechScope @BioTechScope1]

World's first successful xenotransplantation of genetically modified porcine heart with 10 unique gene edits into man with end-stage heart disease . #organtransplant #heartdisease #geneticengineering #geneticallymodified #geneediting @UMMC

https://t.co/4uboZzaYsV