Excited for @CincyClinPharm academic half days to start back up! T32 fellows are in-person & K12 scholars are virtual in other ⏰ zones.
Today’s topics:
-PK of IV drug bolus (chalk talk by @andrewhaynes)
-PGx in Peds
-Mission statement & IDP, goals
@Biruk_TB
Had an amazing time at the @NICHD_NIH Clinical Pharmacology Training Network. The presentations were insightful, and the networking opportunities were invaluable. Truly an educational experience!
Introducing our new @CincyClinPharm T32 fellows & 1st ever K12 scholars!
Thankful for the @NICHD_NIH Clinical Pharmacology Training Network (CPTN) for bringing all of us together for the 1st time since we are from 3 different institutions!
@Biruk_TB@GwendolynPais@andrewhaynes
Through hydrophobic interactions, the lead compound 4 locks the loop responsible for signal transduction in place. Consequently, our compounds engage BlaR with inhibition of signal transduction. Thank you for all co-authors!
Absolutely thrilled to share our latest publication just out in NCB. In this work, we disclose a novel class of boronic-acid-based antibacterial adjuvants that are capable of restoring β-lactam susceptibility in MRSA. https://t.co/mXgHQhlcyk
Downstream signaling ultimately induces the production of the β-lactamases PBP2a and BlaZ.
The approach we report in this work utilizes boronic acid warheads capable of reversible covalent binding to the active-site serine of BlaR.