Blackledge Lab

Cool place to use #NMR to study protein dynamics, highly dynamic molecular assemblies and to discover the functional modes of intrinsically disordered proteins

[Blackledge Lab @BlackledgeLab]

Happy to share our latest article describing how real-time NMR detects hyperphosphorylation-induced conformational changes in the central disordered domain of SARS-CoV-2 nucleocapsid protein that abrogate RNA binding https://t.co/TwiQIYNrdk

[Blackledge Lab @BlackledgeLab]

Incredibly honoured to receive this prestigious prize, highlighting the importance of using NMR to study intrinsically disordered proteins. Testimony to the many brilliant scientists who did us the honour of spending time in the lab
Many thanks to them and to the award committee!

[Institut de Biologie Structurale @IBS_Grenoble]

Congratulations to Martin Blackledge, group leader @IBS_Grenoble, winner of the 2024 Ivano Bertini Award from Instruct-ERIC for his pioneering work on #IDPs using #NMR: https://t.co/5dEIuCMGuP
@cea_grenoble

[Blackledge Lab @BlackledgeLab]

Interested in how avian flu polymerase exploits multivalent interactions with disordered host proteins to replicate in infected cells? We used #NMR to reveal how these remerkable interactions help the virus overcome the species barrier. https://t.co/f8y2lBirNM @IBS_Grenoble

[Blackledge Lab @BlackledgeLab]

Interested in LLPS and IDP dynamics? Find out how @BlackledLab used NMR and MD simulation to reveal the dynamic transition of intrinsically disordered proteins from disperse to phase-separated liquid droplets https://t.co/MN5ixpUiPQ.

[Blackledge Lab @BlackledgeLab]

We are happy to share our recent article in Chemical Reviews showing how NMR Provides Unique Insight into the Functional Dynamics and Interactions of Intrinsically Disordered Proteins https://t.co/grENW9JbTz

[Blackledge Lab @BlackledgeLab]

We are opening ERC-funded postdoctoral positions to use NMR and integrated structural biology to describe highly dynamic viral replication assemblies (SARS-CoV-2, Measles, Influenza). Full description attached.

[Malene Ringkjøbing Jensen @MaleneRJensen]

Happy to share our latest work in @Nature on revealing the structural changes associated with aromatic ring flipping: https://t.co/eRB91zNnOY