Bob Coelingh

[Daniel Hurdiss @DanielHurdiss]

I’m looking for a postdoc to join my team under a recently funded ERC Starting Grant.

If you’re passionate about structural #virology and have experience in #cryoEM SPA and/or #cryoET, get in touch!

Deadline: January 19th.

Please share 🙏

https://t.co/K3nFfjYIgA

[Fabian @EisFabian]

SPACEtomo v1.2 is online! https://t.co/3GO6qP9Z07

- Improved GUIs for lamella detection, target selection and CLEM registration make it the best target selection workflow for PACEtomo on any kind of lamella sample.
- Easier installation and configuration
Any feedback welcome!

[Daniel Hurdiss @DanielHurdiss]

I’m delighted to be among this year’s recipients of the ERC Starting Grant! This funding will allow my group to take a deep dive into the replication and assembly mechanisms of positive-strand RNA viruses. I'm particularly excited to expand our in situ #cryoET capabilities!

[Utrecht Virology Lab @UtrechtVirology]

Our #TeamTomo adventure continues! 🔬

Here is @BobCoelingh's first attempt running MemBrain-seg on one of his tomograms 😍

[NEMI @ProjectNemi]

Next speaker at the 2023 #NEMIday : @DanielHurdiss (@UtrechtVirology ) on the sweet secrets of common cold #coronaviruses

[Daniel Hurdiss @DanielHurdiss]

How can you convince a coronavirus to share its cell entry secrets?

Give it something sweet! 🍬

Using #cryoEM & MD, we show how a sugar-based receptor binds to the HKU1 spike and triggers opening via an allosteric mechanism (🧵).

https://t.co/Jsm61GjTk8

#glycotime #virology

[Matti Pronker @MFPronker]

And it's out! Check out our paper in @Nature on the human coronavirus HKU1 spike binding to a sialoglycan receptor, leading to spike opening via large conformational changes.

Massive thanks to @DanielHurdiss, @raouljdegroot and all co-authors!

https://t.co/FOBbm737OK

#cryoEM

[Utrecht University @UniUtrecht]

🔬Onderzoekers van @UtrechtVirologie @DanielHurdiss hebben een vernuftig mechanisme ontdekt waarmee spike-eiwitten van het coronavirus worden geactiveerd om gastheercellen binnen te dringen. Het onderzoek is gepubliceerd in @Nature. Meer informatie: https://t.co/w7E67vpU2r

[Daniel Hurdiss @DanielHurdiss]

Exciting News 🎉

Our discovery, revealing that a primary sugar-based receptor can trigger the opening of the HKU1 spike, is now online at @Nature!

https://t.co/wfdhrmVlLI

A huge thanks to @raouljdegroot and the entire team for this exciting collaboration!

#cryoEM #glycotime

[Utrecht Virology Lab @UtrechtVirology]

Our #TeamTomo wunderkind @BobCoelingh had a go at making some @SchurLab cell culture grid holders!

https://t.co/Nl1TCaQpEP

A big thanks to @proteincapsid for pointing us towards this solution and @LilisProtoLab for access to the 3D printing facilities!

[Bob Coelingh @BobCoelingh]

@joostsnijder Congratulations!!!