Brandon Dale James

On the Eighth day, God created the Spork - God’s gift to man!

[Brandon Dale James @BrandonDJamesSF]

Critically Think This Through!

https://t.co/2nca3dVsNx

[Brandon Dale James @BrandonDJamesSF]

2026

[Brandon Dale James @BrandonDJamesSF]

State of the Union Address (2022).
figured I’d send it a little early, hope it’s alright?
-Skull Duggery & Noreaga & Troy Outlaw - Hoodlum Or Thugged Out (1998) https://t.co/xNjSm50C6r via @YouTube

[SaaStr.ai @saastr]

🚀 Anthropic's revenue trajectory is absolutely insane:

📊 2022: $10M
📊 2023: $100M
📊 Dec 2024: $1B ARR
📊 July 2025: $4B ARR

That's 100x growth in 3 years and 300% growth in just 7 months 🤯

While OpenAI pioneered this pace, Anthropic is proving enterprise AI demand is MASSIVE and sustainable.

The AI infrastructure goldmine is real 💰

[Jolie @joliegans]

When I tell you I inhaled this book, I mean I read it in one sitting, then 7 times over again. I've recommended it 57 times, gifted 12 copies, and lovingly annotated it on 6 flights.

Donald Braben's Scientific Freedom is an eulogy to scientific discovery, autopsied while it was still alive.

He predicted the current landscape of research, 17 years before it happened. We went from 500 people who could conduct and execute on research to 50,000 locked in cages of incremental work. Young scientists don't even bother anymore (they just leave).

We didn't get dumber. We built a system that punishes risk. I would argue that most Nobel-winning discoveries from the 20th century would be rejected today (too weird! Too slow! Too uncertain!)

Since 2008:
> Peer review times have tripled
> Federal grant success rates fall below 20%
> First-time PI age is approaching 50
> (new!) Research funding cuts up to 43%

I've spent the last few weeks mapping what Braben saw coming and stress-testing his arguments in 2025, what he missed, new challenges, and what we can adapt from here. Deep dive follows below!

Very few books make me go wow, let alone restructure my entire paradigm. @stripepress knew what they were doing bringing this back. Everyone even remotely adjacent to scientific research needs to read this.

[a16z crypto @a16zcrypto]

Situational awareness: Living in the ‘yellow’

[a16z crypto @a16zcrypto]

Personal and physical security for founders, operators, and investors

→ https://t.co/uABxPHobqF

[Brandon Dale James @BrandonDJamesSF]

Key moment in history?
https://t.co/Le68NSd9GY

[Brandon Dale James @BrandonDJamesSF]

Critically Think This Through!

https://t.co/2nca3dVsNx

[Brandon Dale James @BrandonDJamesSF]

https://t.co/0IYTvwoApk

[Suffiyan Malik @suffiyanmalikk]

Scott believes in creating categories

Cc @lochhead

[Jason Abaluck @Jabaluck]

The total payroll of the federal government is about $110 billion a year https://t.co/X1iWtW8aBe

Federal government spending was $6.1 trillion https://t.co/7ZuK3NqoFr

You cannot meaningfully shrink the federal government by firing "unelected bureaucrats"

[Start it up @startitup_]

"All niches are saturated." — by @mattgiaro https://t.co/TW3s9EuhoK

[Boost VC @BoostVC]

Boost VC leads Pre-Seed rounds for Deep Tech (crypto, space, bio, AI, robotics, VR, Sci-Fi).

Founders: Apply for investment: https://t.co/2yvps1zYmK

Investors: Join demo day: https://t.co/Lm9aWsrZSg

[Boomtown Innovation @Boomtown]

Today at the Colorado Health Innovation Summit, Boomtown's own Head of Innovation, Steve Tremitiere will moderate the “Colorado’s Living Lab” panel at 1PM in Conference Room 2. They’ll explore how Colorado can serve as a living lab for mental health and well-being innovations.

[INSEAD @INSEAD]

Are you looking to bring on board high-calibre talent with global insights and a fresh perspective?

Whether you’re looking to hire for full-time positions, internships, or project-based roles, gain exclusive access to top candidates today.

With our online portal, you can easily:
- View detailed talent profiles
- Tailor your search to match your hiring needs
- Post job opportunities and manage recruitment, all in one seamless platform

➡️ Recruit now https://t.co/opW442SOKP

#INSEAD #MBATalent #CorporateRecruitment #TalentAcquisition #Hiring

[INSEAD Knowledge @INSEADKnowledge]

For every global hit performed by BTS or Blackpink, hundreds of songs penned are seldom or never heard. With most songs created by freelance melodists, lyricists and arrangers working in temporary teams, expanding your #network is crucial for success.

https://t.co/qOcIqkWJLJ

[Techstars @Techstars]

Here are the tips and tricks to get noticed when applying for a Techstars accelerator program. 👀
https://t.co/slH9NtOvrz

[Gust @gustly]

Financial Model Makeover on Thurs!

Join Gust & the @forecastr team for an awesome breakdown 🕺 & buildup 🏗 of an early stage startup's financial model. 📊

You'll see what investors like/dislike in a model, & how you can make the proper changes to fine-tune your own model.

[Brandon Dale James @BrandonDJamesSF]

?

[David Bernstein @ProfDBernstein]

This looks like a *criminal* violation of the federal Fair Housing Act. Stanford should call the FBI, but since it likely won't, the student should.

[Brandon Dale James @BrandonDJamesSF]

Evil is here!

[Erik Voorhees @ErikVoorhees]

Announcing Venice

Today, we launch private, permissionless AI for the purpose of unfettered civilizational advancement: https://t.co/m2jsJuDuXS

Full announcement:
https://t.co/lPIDpgI9K1

@TryVenice

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