I am Brian Opp

Husband and friend. Pop culture and sports junkie. I just want the green m&m to get her boots back.

[Dr. Pat Soon-Shiong @DrPatrick]

Looking forward to presenting at AUA soon. Chemotherapy induces lymphopenia with increases in recurrence rates in bladder cancer, while BCG is an established immunotherapy. We need to fix the 14 year BCG shortage situation and it’s not through an alternative of more chemo which even results in fatality from the chemo. It’s to find alternative BCG. Stay tuned.

[GainzAlgo @gainzalgo]

$IBRX

Listen to this.

If Fox Business is right and Makary’s resignation was tied to Sen. Ron Johnson pressing for answers on the FDA���s rejection of cancer drugs and immunotherapies, that is a massive storyline.

This is exactly the kind of pressure the FDA needed.

Cancer patients do not have time for arbitrary gatekeeping, politics, or endless delays while promising immunotherapy platforms sit waiting.

Makary is out, Kyle Diamantas is acting FDA commissioner, and the whole oncology approval conversation just got a lot more interesting for $IBRX.

I could verify Makary’s resignation and Diamantas being named acting commissioner from current reporting, but I’d still phrase the Ron Johnson/Fox angle as “if Fox Business is right” unless you have the clip linked.

[I am Brian Opp @BrianOpp1]

@SierraCPerry @concertleaks If “scalpers” actually bought PCD tickets and provided guaranteed upfront revenue, they wouldn’t have had to cancel their tour due to poor ticket sales.

[I am Brian Opp @BrianOpp1]

@MarkBra24595441 @Djoko_UTD nah. we really don’t care. But if our sport starts declining in popularity like tennis, we may start to feel threatened and care as much as you currently do.

[I am Brian Opp @BrianOpp1]

@DrPatrick @elwalvador Preach, PSS!

[U.S. Senator John Fetterman @SenFettermanPA]

Let’s see who grieves for that garbage.

[Dr. Pat Soon-Shiong @DrPatrick]

So here is the logic. Anktiva (IL-15) was ranked number ONE to cure cancer. Keytruda was ranked number TWO by NCI in 2007. Anktiva GROWS T CELLS. Keytruda takes the BRAKES OFF THE T CELLS.

Eventually Keytruda fails since there are no T cells to take the brakes off. So if T cells could be replenished by GROWING T CELLS WITHIN YOUR BODY AS THE FACTORY and STIMULATED WITH IL-15 by growing T crlls together with NK cells, Keytruda can be rescued and allow T cells to work again and prolong life.

Well that is EXACTLY what we showed in our lung cancer trials and our trial with over 10 different tumor types and presented this data to Saudi FDA… resulting in approval of Anktiva in combination with Keytruda to prolong lives of patients with lung cancer who had failed all standards of care and whose tumors were spreading and growing while on Keytruda!

So in short the combination of number 1 with number 2 ranked molecules of the immune system is both biologically rational and logical based on their MECHANISMS OF ACTION. And last night @DrJBhattacharya mentioned loudly that FDA wants to accelerate approvals based on their doctrine of “plausible mechanism of action”. Anktiva’s mechanism has been validated by FDA themselves within the approved package insert!

With regard to single arm trials: Number two ranked drug developed over last decade (with 40 FDA approvals and approved for multiple tumor types with SINGLE ARM TRIALS FOR MSI high for Merck). So when combined with the Number ONE ranked drug to rescue the number two, then magic happens. But it’s not magic… it’s the biology of your immune system… NK cells rescue T cells. The single arm trial with very mature data was accepted by Saudi FDA to enable their population to have access to this combination.

This is the enlightenment that is needed!

https://t.co/lh0frZJrD8

[Dr. Pat Soon-Shiong @DrPatrick]

Here is the mind map that I deconstructed for the audience at the Milken /Nixon summit today.
So glad that Carl June and Jim Allyson were in the audience !!

This was the first time in 10 years that I presented our work to explain this map I drew in Jan 2016. It was fun to unveil our hypothesis and the validation for the first time ( and I am not sure if it surprised a lot of people!) and reveal the decade of work that has gone into proving the hypothesis that a paradigm change is need..Lymphopenia matters and now we can treat it! The tumor itself shift shapes while at the same time the immune cells do the same in response..enormous complexity of quantum change, but we have now figured how to dance with that quantum music and outsmart the disease! Enjoy the AI podcast of a portion of this mind map..it took about half of this drawing. Next time I will dictate the rest

[Elon Musk @elonmusk]

Yeah

[LA Times Studios @latimesstudios_]

Saudi Arabia’s Vision 2030 establishes the Kingdom as a next-generation biotech hub, reflecting a modern, forward-thinking commitment to innovation and full integration as a national priority.

https://t.co/taTj9KGZNG

[Dr. Pat Soon-Shiong @DrPatrick]

We have now initiated the process of establishing the WORLD BANK OF NATURAL KILLER CELLS and identified global cancer centers where our robots will be installed.

Imagine if this can now be automated so that TRILLIONS OF NK cells can be stored and even engineered as CAR-NK cell therapy for the entire globe as off-the-shelf therapy with Anktiva! Its here.

The AI driven manufacturing robot (Leonardo) has been trained with our software and more news to come soon on that... the world of memory cytokine enhanced NK cells or M-ceNK for short. @ImmunityBio

[I am Brian Opp @BrianOpp1]

@LoverYamper @NoaDalzell If you open your eyes, you’ll realize what price floors, price controls do if you let a monopoly control tickets and not individuals sellers competing against one another .

[I am Brian Opp @BrianOpp1]

@LoverYamper @NoaDalzell You don’t understand what you are talking about.

[Ben Meisel @TicketsData]

Another great example of the benefits of the secondary market is @jadethirlwall tour.

$50 from Ticketmaster
$5 on TickPick

[Dr. Pat Soon-Shiong @DrPatrick]

An urgent discussion trying to bring understanding of what is at stake! Our immune system is the key to life. The key to longevity. The key to changing how we treat cancer. I will show the presentation by NCI, NIH and even FDA in 2007 that ranks our drug of IL-15 that was identified by all them in a FULL CONSENSUS THEN ( 2007!!!) to be the NUMBER ONE CYTOKINE that could cure cancer .. power point of that meeting coming next .. please read!

[The Kitchen Pickleball 👨🏻‍🍳 @TheKitchenPB]

Dude in blue about to break the internet. 💻💥

[The Kitchen Pickleball 👨🏻‍🍳 @TheKitchenPB]

If this doesn’t win an ESPY the whole thing is rigged. 🤯

[Nice Bison @Nice_Bison]

My view on August 31, 2024. The first game of the Indiana Curt Cignetti era

[Pheap @Canossi_PC]

This one is for my sweet sister, mom of 2 battling stomach cancer $ibrx 🙏

[Dr. Pat Soon-Shiong @DrPatrick]

Seeing is believing. The patient with multiple bone tumors after failing standard of care and complete response after just 4 doses of our targeted NK cells. And now in ongoing remission 7 months with no further treatment. The power of NK cells is self evident.

Outpatient treatment without lymphodepletion and toxic chemo. A paradigm change

https://t.co/pBuLJz3Mer