Carla Carol Winter

she/her
MD-PhD trainee @harvardmed @mit_hst
interested in cellular and molecular neuroanatomy 🧠 neural injury and repair
@mitchellscholar '17
@pennbioeng '16

[Preston Ge @ge_preston]

New Emergent Properties blog post! In it, I talk about how the "streetlight effect" - searching where the light is brightest rather than where answers likely are - shapes research decisions and what we end up studying.

(1/7)

#scicomm #STEM

[Kaitavjeet Chowdhary @kaitavjeet]

After many fun discussions with friends in our MD-PhD program, we’re excited to launch our new blog!https://t.co/F4jYuUcqxA We'll explore ideas at the interface of clinical medicine and basic science. Already some great posts up—on evolution, big data, and abstraction in biology!

[Preston Ge @ge_preston]

After a year of exciting discussions with friends in my MD/PhD program, we're delighted to share our blog exploring the intersection of science and medicine: https://t.co/diFurTxm5h

Many cool posts up, on topics such as abstractions in biology, big datasets, and evolution!

[Rahul Gupta @rahulg603]

How do experts gain intuition?💡

I argue:
1. expert intuition (“fast”) = pattern-matching on past experiences
2. careful reasoning (“slow”) = confronting a new scenario with step-wise thinking
3. wise decision-making toggles between both styles

https://t.co/nLoUrlCvKw

[Trina Vargo @trinavargo]

Perfect time for @JoeBiden @KamalaHarris @jakejsullivan @ECA_AS @USAmbIreland to announce that the USG give, will match @SimonHarrisTD @MichealMartinTD @dfatirl @DFHERIS @IrelandAmbUSA on @MitchellScholar endowment? We’d happily add @POTUS name to it. https://t.co/4OPdYhr7pw

[Rahul Gupta @rahulg603]

Excited to see this out! We quantified mtDNA copy number across ~10k GTEx samples (52 tissues), 20 mouse tissues & 173 human cancer cell lines. Integrating these data produced several insights, including that high-mtCN cell lines can resist GPX4 loss. https://t.co/f9AiHhIC60

[Carla Carol Winter @CarlaCWinter]

@ge_preston Yay deborah!

[Carla Carol Winter @CarlaCWinter]

Find the whole BRAIN Initiative Cell Census Network 2.0 collection here: https://t.co/DB4UuEVBeb

More here: https://t.co/JFrKVt9asf

#BICCN

(7/7)

[Carla Carol Winter @CarlaCWinter]

The paper was a HUGE collaborative effort - particular thanks to my thesis advisor Zhigang He, lab colleagues Anne Jacobi, Junfeng Su, Leeyup Chung; exceptional collaborators at Allen Institute @HongkuiZeng, Bosiljka Tasic, Zizhen Yao, Cindy van Velthoven, CK Lee, & others. (6/7)

[Carla Carol Winter @CarlaCWinter]

We use this to dig into SPN biology, including (1) a TF code defining the composition and spatial location of reticulospinal neurons, (2) transcriptomic differences b/w cervical- & lumbar- projecting SPNs, (3) electrophysiologically distinct types of rubrospinal neurons. (5/7)

[Carla Carol Winter @CarlaCWinter]

Division 1 includes exclusively excitatory SPNs from the cortex, red nucleus, and deep cerebellar nuclei, Division 2 are transcriptomically heterogeneous reticulospinal neurons, and Division 3 are “modulatory” SPNs express slow acting neurotransmitters or neuropeptides. (4/7)

[Carla Carol Winter @CarlaCWinter]

The taxonomy includes 65,002 SPN snRNAseq profiles after QC from 6 brain regions (cortex, hypothalamus, midbrain, pons, medulla, cerebellum). We find these profiles organize into 3 main “Divisions”. (3/7)

[Carla Carol Winter @CarlaCWinter]

Excited to see our paper out in @Nature last week! As part of a larger effort to develop a cell type atlas of the whole mouse brain, we built a brain-wide anatomic and transcriptomic atlas of adult mouse spinal projecting neurons (SPNs). (1/7) https://t.co/nOPfyEgcEE

[Carla Carol Winter @CarlaCWinter]

SPNs are the neurons that link the brain to the spinal cord, enabling us to transform our "thoughts" into "actions". To create this atlas, we used retrograde labeling, whole brain imaging, snRNAseq, and integration with MERFISH data generated by Yao et al, Nature, 2023. (2/7)

[Joyce Kang @joycebkang]

Excited that our single-cell eQTL study of HLA genes is out now in @NatureGenet! ⭐️ https://t.co/bYtyjliKF8
Huge thx to @soumya_boston @saorisakaue @yluo86 for their guidance

Check out this great News & Views by the Gaffney lab describing the key points: https://t.co/J0i6AvdSzJ

[Nature Reviews Genetics @NatureRevGenet]

Human genetics: Nuclear genome influences mitochondrial DNA https://t.co/PU4IIybLTZ #ResearchHighlight by @haertl17

[Loren Walensky @LorenWalensky]

A weekend to remember! With record-breaking attendance, the 41st annual @HarvardMITmdphd retreat on Cape Cod was the perfect mix of science, festivities, comradery, & inspiration. An incredible group of empathic, multitalented difference makers. @NIGMSTraining @harvardmed @MIT

[Carla Carol Winter @CarlaCWinter]

Congrats @rahulg603 and team!

[Rahul Gupta @rahulg603]

Out today @Nature – our analysis of the influences of common nuclear DNA variation on mitochondrial DNA copy number and heteroplasmy across >250,000 people across two biobanks! https://t.co/VjYsSE0BOg

[Carla Carol Winter @CarlaCWinter]

Hey look I know that guy!

[The Harvard/MIT MD-PhD Program @HarvardMITmdphd]

Big congrats to @HarvardMITmdphd student @rahulg603 and his advisors @VamsiMootha and @bmneale! Rahul successfully defended his thesis entitled, “Nuclear genetic control of mitochondrial function and its contribution to human disease: insights at biobank scale.” @BBS_Harvard

[Carla Carol Winter @CarlaCWinter]

Yay cat!

[Loren Walensky @LorenWalensky]

Big congrats to the amazing Cat Newman @CeNewman24 on her PhD thesis defense today in Chemical Biology! The Walensky lab is super proud. We will miss your daily presence as you head back to @harvardmed to complete the final 2 years of your MD-PhD! @DFCI_ChemBio @chemical_phd