Léa Caya-Bissonnette, PhD

PhD in Neurosciences, University of Ottawa. Synaptic electrophysiology & cortical plasticity.

[Léa Caya-Bissonnette, PhD @CayaBissonnette]

Interested in behavioral timescale synaptic plasticity (BTSP)? Associative learning? Eligibility traces? Temporal credit assignment problem?! Check out our preprint 👇! (1/13) #synapticplasticity #BTSP @NeuroNaud @JCBeique

https://t.co/f2oUTZQcsG

[Dr. Rajesh Khanna of the KhannaLabUF @KhannaLabUF]

Wow, this is great!! Fantastic teaching resource to boot.

[Léa Caya-Bissonnette, PhD @CayaBissonnette]

For a refresher on the great classics, or a glimpse into the future, check out this review by @JCBeique & I on 50 years of Long-term Potentiation, and what the next 50 years might hold!

https://t.co/W1j4Ty1PG5

[John Beninger @jgbeninger]

Clustering model parameters across hundreds of synapses, we found five functional subtypes of synaptic dynamics in rodents and six functional subtypes in humans which show qualitative overlap (though based on existing data we don’t expect a perfect overlap).
4/10

[Léa Caya-Bissonnette, PhD @CayaBissonnette]

MUST read - Amazing work showing functional clusters of short term plasticity! Congrats @jgbeninger 🎉👏

[John Beninger @jgbeninger]

Interested in short-term plasticity? Our recent findings have just been published! With @Neuronaud @mossy_fibers @j_rossbroich
Online: https://t.co/oJIQbxQGkE
1/10

[Richard Naud @NeuroNaud]

If you're interested in dendritic computation, our most recent findings are just published! With @Z_Friedenberger and at @NatComputSci
Direct access: https://t.co/GsccNFrFHy
Online: https://t.co/8DO9aYSRwC

[Nima Raman @RamanNima]

I’m pretty overdue but this photo reminds me of this exciting day when I had a chance to moderate the trainee talks along with @CayaBissonnette at Centre for Neural Dynamics Research Spotlight organized by @uOttawaBMRI, & enjoy a beautiful talk by @nspruston back in September!

[Neuroskeptic 🇺🇦 @Neuro_Skeptic]

A new theory of serotonin function: it encodes "cumulative future reward" aka state value https://t.co/6rpCfW5gR5 Compared to dopamine, serotonin is a lot more mysterious

[Léa Caya-Bissonnette, PhD @CayaBissonnette]

Great piece of work by @efharkin_ on serotonin and value encoding 👏

[Emerson F. Harkin @efharkin_]

What do you get when you combine RL and predictive coding? The in vivo activity patterns of serotonin neurons.

Excited to share a new theory and analysis to back it up! https://t.co/P6iYZClUGA

With @NeuroNaud and @JCBeique in collab with @grossmancooper & @JeremiahYCohen.

🧵

[Toviah Moldwin @TMoldwin]

@CayaBissonnette @NeuroNaud @JCBeique Great work! We also have a calcium-dependent model of a different aspect of BTSP here: https://t.co/9CvM02iohC, I'd be interested in hearing your thoughts - maybe you can DM me and we can talk over Zoom some time?

[Léa Caya-Bissonnette, PhD @CayaBissonnette]

@TMoldwin @NeuroNaud @JCBeique Hi Toviah, i stumbled upon your paper a couple of weeks ago and found it very useful! Congrats on the paper & would love to chat!

[Léa Caya-Bissonnette, PhD @CayaBissonnette]

Interested in behavioral timescale synaptic plasticity (BTSP)? Associative learning? Eligibility traces? Temporal credit assignment problem?! Check out our preprint 👇! (1/13) #synapticplasticity #BTSP @NeuroNaud @JCBeique

https://t.co/f2oUTZQcsG

[Léa Caya-Bissonnette, PhD @CayaBissonnette]

@argalloni @NeuroNaud Synapse specificity can still be obtained however, since the ET transformation is contained within the activated synaptic cluster.

[Léa Caya-Bissonnette, PhD @CayaBissonnette]

@argalloni @NeuroNaud It is possible that IP3Rs bypass the requirement for an additional molecular marker. IP3Rs require calcium and IP3 to open, which may be triggered by two independent sources. The exclusivity of this may depend on location and kinetics of calcium and IP3.

[Léa Caya-Bissonnette, PhD @CayaBissonnette]

@argalloni @NeuroNaud Great question! We have been giving some thoughts to this as well. Indeed, there might a be molecular marker that requires both pre- and postsynaptic activity, and that interacts with ER release, for LTP induction. We have not experimentally tested this.

[TTchumatchenko @TTchumatchenko]

@NeuroNaud Very interesting paper, thanks for sharing! So cool that you are also venturing into the molecular world and building a bridge to the circuit level.

[Ching-Lung Hsu @hiallen72]

Beautiful work by @CayaBissonnette @NeuroNaud @JCBeique
Cellular Substrate of Eligibility Traces https://t.co/YfZLV4Myde

[Léa Caya-Bissonnette, PhD @CayaBissonnette]

@FemtonicsUSA @NeuroNaud @JCBeique Thank you @FemtonicsUSA !!

[Justin O'Hare @JustinKOHare]

Intracellular calcium steadily making its overdue comeback to the big stage 🫡🍿

[Léa Caya-Bissonnette, PhD @CayaBissonnette]

@JustinKOHare Looking forward to seeing what research you are cooking up next @JustinKOHare !

[Sébastien Maillé @sebmaille]

Amazing work! Congrats @CayaBissonnette, @NeuroNaud and @JCBeique 🥳🤩

[Michael Lynn @MichaelBLynn_]

Outstanding work by great people - a cellular model of eligibility traces! Check it out 🎉