Cd20+DLBCL

Tweeting at interface of Science, medicine, politics, and business. Apologist for medicines and medical device regulators: unsung heroes of COVID.

[Cd20+DLBCL @CDlbcl]

This headline is inappropriately alarmist given the content of the paper.

It will obviously be misused by anti vaxxers.

I thought it worth a short thread to highlight what it means.

TL;DR nothing in this paper undermine trust in data on BioNtech / Pfizer trials.

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[The BMJ @bmj_latest]

NEW: Our latest investigation hears from a whistleblower engaged in Pfizer’s pivotal covid-19 vaccine trial. Her evidence raises serious questions about data integrity and regulatory oversight https://t.co/Ho99hQhwRM

[Cd20+DLBCL @CDlbcl]

@Otto_English Looks like there might be a slight penetrating damp problem.

[Cd20+DLBCL @CDlbcl]

@ThomasVerrier Has anyone else noticed how much that black hole looks like a cardiac spect scan?

[Cd20+DLBCL @CDlbcl]

@SamuelMarcLowe Yep. You got it.

[Cd20+DLBCL @CDlbcl]

@andrew_croxford @3rd_reviewer @endpts Indeed. I suspect BioNtech has had some difficult strategic questions to address with their share price falls over recent months.

[Cd20+DLBCL @CDlbcl]

@JFruoco @jamesewand Car temps 40+ are then norm in grenoble in the summer (at least in our car)

[Cd20+DLBCL @CDlbcl]

@Elise_ML Good thread. Thanks.

[Cd20+DLBCL @CDlbcl]

Absolutely hilarious for those who read French.

[Bkg2k Recalbox @Bkg2kR]

Ce matin, une notification de colis arrive. Un Atari 800XL obtenu pour une poignée d'€.
Donné pour mort, j'espérais pouvoir en récupérer quelque chose.
Boitier cassé, trappe cartouche forcée au pied de biche, et touche option en piteux état...
"On verra bien" me disais-je.

[Bkg2k Recalbox @Bkg2kR]

Ce matin, une notification de colis arrive. Un Atari 800XL obtenu pour une poignée d'€.
Donné pour mort, j'espérais pouvoir en récupérer quelque chose.
Boitier cassé, trappe cartouche forcée au pied de biche, et touche option en piteux état...
"On verra bien" me disais-je.

[Cd20+DLBCL @CDlbcl]

@plod1956 In retrospect of was certainly poor risk management.

[Cd20+DLBCL @CDlbcl]

Fascinating thread on the German elite (especially SPD) being played by Putin.

TL;DR, dialogue, economic and personal links are not a good thing in themselves.

Was the German elite weakened by Putin when they thought they were influencing him for the better?

[Oliver Moody @olivernmoody]

In Terry Pratchett’s Discworld book Carpe Jugulum, the hilly kingdom of Lancre is taken over by vampires, who feed on Granny Weatherwax, the most powerful of the country’s witches. What has this got to do with Germany’s Russia policy? A 🧵(warning: contains Discworld spoilers) /1

[Cd20+DLBCL @CDlbcl]

@batched_fufi Same issue in many western countries: France, Italy and also UK which has allowed Putin's cronies too much influence.

[Cd20+DLBCL @CDlbcl]

@bchadwickfrance I was doing my covid duty this morning in the local commune. I play clarinet in the local orchestra harmonie and we play outside the war memorial and Marie each 11 nov and 8 mai. I always find it a moving ceremony.

[Cd20+DLBCL @CDlbcl]

@jamesewand Well yachts have both sails and decks. Perhaps you get a yacht?

[Cd20+DLBCL @CDlbcl]

@jamesewand Perhaps it illustrates low productivity of UK economy more generally?

[Cd20+DLBCL @CDlbcl]

@johnb78 I like the precision of the end of the final tweet "wait a bit and you are good to go"

[Cd20+DLBCL @CDlbcl]

@JuliusWaller @maxfras Monaco too. And moncaco is a better place to keep your yacht than Lichtenstein.

[Cd20+DLBCL @CDlbcl]

@JXB101 Presumably this also explains why the PM apparently never buys John Lewis.

[Cd20+DLBCL @CDlbcl]

@Stockdog23 @gadboit And aducanumab was for a common illness - Alzheimers - for which current drug treatments are both poor and (because they are out of patent) cheap. So that drug could have had a big impact on healthcare costs on societies with lots of elderly people.

[Cd20+DLBCL @CDlbcl]

@Stockdog23 @gadboit The cost of pharmaceuticals is very dependent on the disease area concerned.

Biogen trying to charge $54k a year for aducanumab was taking the piss IMHO given lack of hard evidence of actual good outcomes of benefit to society And it has been a commercial disaster for them.

[Cd20+DLBCL @CDlbcl]

@Stockdog23 @gadboit And that does require some risk sharing from governments through R&D tax incentives and grants, in exchange for price controls based on patient benefit. Pfizer success in covid is quite a good example.

The US doesn't yet have that balance right more generally.

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[Cd20+DLBCL @CDlbcl]

@Stockdog23 @gadboit Concepts like responsibilith to patients, reasonable prices, access are values the Pharma industry sometimes fails to live up to, eg Purdue Pharma.

We need an environment in which Pharma shareholders get good returns developing innovative medicines sold at fair prices.
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