Matt Sheridan

Christian, Father of 3 amazing boys, married to my lovely wife Corrie, Bills Mafia

[Matt Sheridan @ChaChing_F3]

@BobLonsberry Woah Bob - that’s amazing

[Ihtesham Ali @ihtesham2005]

A neurobiologist at Columbia spent 30 years proving that the gut has its own brain, and the day he finally published the book that named it, almost every psychiatrist in America stopped returning his calls.

His name is Michael Gershon.

He runs the Department of Anatomy and Cell Biology at Columbia University Medical Center in New York, and the field he built from the ground up is called neurogastroenterology in short brain-gut axis.

The book that announced it to the world was published in 1998, and the title alone tells you everything about what he was up against. He called it The Second Brain.

The claim sounded like science fiction in the 1990s. Gershon was saying that the human gut contains its own fully functional nervous system, with around 100 million neurons embedded in the walls of the alimentary canal, which is the nine-meter tube running from your esophagus to your anus.

That is more neurons than your entire spinal cord, and more than your entire peripheral nervous system put together. The gut was not just digesting food. It was running its own intelligence, with its own reflexes, its own memory, and its own way of deciding what to do without asking the brain in your head for permission.

The medical establishment treated this as borderline heretical when he first started publishing it. The brain was supposed to be the command center. Everything else was supposed to be the periphery. A second brain in the belly did not fit the architecture anyone had been taught.

Then the data started piling up, and it was impossible to argue with.

The first finding that broke the old model was about serotonin. You might have heard Andrew Huberman talking about it on his podcasts. Serotonin is the neurotransmitter associated with mood, well-being, sleep, and depression. Every antidepressant on the market targets it.

The assumption for decades was that serotonin was a brain chemical, produced in the brain, regulated in the brain, and responsible for what happened inside the brain.

Gershon's lab showed that 90 to 95 percent of the body's serotonin is not produced in the brain at all. It is produced in the gut, by specialized cells called enterochromaffin cells embedded in the intestinal lining.

Your stomach and intestines are the largest serotonin factory in the human body, and the brain in your skull is producing only a tiny fraction of what is circulating below your neck.

The second finding was even harder to swallow. The vagus nerve is the longest cranial nerve in the body, running from the base of the brain down through the neck, the chest, and into the abdomen, where it branches into the gut. For most of the 20th century, doctors assumed the vagus was the brain's way of giving orders to the digestive system, in the same way the brain gives orders to the rest of the body.

The actual measurements showed almost the opposite. Roughly 90 percent of the fibers in the vagus nerve are carrying signals upward, from the gut to the brain, and only a small fraction are carrying signals downward. Your gut is sending nine times more information to your head than your head is sending to your gut.

The bandwidth is wildly asymmetrical, and almost all of it is going in a direction the medical textbooks had quietly been wrong about for decades.

The implication of those two findings together is what changed psychiatry.

If most of your serotonin is being produced in your gut, and most of the information flowing through your vagus nerve is moving from your gut to your brain, then your mood is being shaped from the bottom up far more than it is being directed from the top down.

The feeling of dread before a difficult meeting. The sudden clarity after a good meal. The low-grade anxiety that will not go away no matter how much you talk through it. All of it is downstream of signals that started below your diaphragm.

A 2019 study at McMaster University put the final piece in place. Researchers gave mice oral antidepressants and watched what happened. The drugs activated the vagus nerve from the gut side, and the gut-to-brain signaling was what produced the antidepressant effect.

When they cut the vagus nerve and tried the same drugs, the antidepressant effect disappeared completely. The drug was not working on the brain directly. It was working on the gut, and the gut was working on the brain.

The follow-up research on the microbiome made the connection even tighter. Mice raised in completely sterile environments with no gut bacteria produced about 60 percent less serotonin in their intestines than normal mice. When the bacteria were reintroduced, serotonin production returned to normal.

The trillions of microorganisms living in your digestive tract are not passengers. They are running the factory that makes the chemical your antidepressant is trying to manipulate.

The most haunting line from Gershon's interviews is the one I keep coming back to.

He said the second brain does not do philosophy or poetry, and it cannot help you write a novel. But it is the brain that decides whether you wake up in the morning feeling like the day is full of possibility or feeling like something is wrong before anything has even happened.

The mood you assume your conscious mind is generating from your thoughts is mostly being generated underneath you, by a nervous system you cannot feel and cannot consciously access, in an organ you have spent your entire life thinking about as a digestion machine.

The decision your gut makes about how you are going to feel arrives in your head a fraction of a second before your brain catches up to it. The conscious thought is the explanation your mind invents for a verdict that has already been reached somewhere lower.

You did not feel uneasy because you were thinking dark thoughts.

You started thinking dark thoughts because your gut was already uneasy.

[Camus @newstart_2024]

RFK Jr. just delivered a raw wake-up call as HHS Secretary:

America isn’t just facing a mental health crisis — we’re facing a dependency crisis driven by over-medicalization.

The numbers he laid out are staggering:
• 1 in 6 adults on antidepressants
• 1 in 10 children on psychiatric medication
• Over 30% of college students using them in the past year

He announced concrete action: new national guidance pushing non-drug treatments first, real informed consent, and — for the first time — proper training and payment for safe tapering and deprescribing.

He was especially blunt about withdrawal, sharing that for many it’s far worse and longer-lasting than even heroin withdrawal.

Similar trends are visible across Europe and the UK, where antidepressant prescriptions have reached record highs in recent years. For decades we’ve defaulted to pills as the first answer. This is one of the clearest signals yet that over-reliance on psychiatric medication is finally being questioned at the highest levels.

Too many people feel trapped on these drugs with little guidance on how to safely reduce or stop them.

What do you think — is it time we seriously rethink how freely these drugs are prescribed, especially to children and young adults?

[Matt Sheridan @ChaChing_F3]

@SamBrownUSA Had to do a double take - captured the same! What a beautiful ending to a great Easter Sunday. God bless

[NYSE 🏛 @NYSE]

.@SunbeltRentals aims to be a leader in equipment rental, with a coast‑to‑coast presence and a broad lineup of products and services.

From the job site to Wall Street, welcome to the NYSE Community 💚 $SUNB

[NYSE 🏛 @NYSE]

A bright new listing on the Big Board. @SunbeltRentals celebrates its IPO! $SUNB https://t.co/KNE3ZV6mlH

[Matt Sheridan @ChaChing_F3]

@thebrettjames1 Goon

[Matt Sheridan @ChaChing_F3]

@thebrettjames1 This is great

[Hänsel @UberHansen]

Josh Allen started the game with a broken foot. Then someone jumped on his head. Then he smashed his throwing hand on a helmet. Then he hyperextended his knee.

306 yards and 3 TDs later, the #Bills won the game.

[Matt Sheridan @ChaChing_F3]

@danorlovsky7 @BuffaloBills YES

[Matt Sheridan @ChaChing_F3]

The tradition continues #BillsMafia

Funny what players my boys pick each year.

#gobills

[Matt Sheridan @ChaChing_F3]

@ESPNNFL @Realrclark25 #clown

[Dion Dawkins @DDawkins66]

#BillsMafia I need your help 😳Hit the RT to cast your vote and bump me up to 1st place to support Dion’s Dreamers ⛄️

#WPMOYChallenge @DDawkins66

[Matt Sheridan @ChaChing_F3]

@stoolpresidente Hmmmm

[Matt Sheridan @ChaChing_F3]

@RealSkipBayless Ahhheeemmmmm

[Matt Sheridan @ChaChing_F3]

@NFL_DovKleiman Ben Coates

[Matt Sheridan @ChaChing_F3]

@RealSkipBayless Clown

[Eric Daugherty @EricLDaugh]

🚨 BREAKING: Polk County Florida Sheriff Grady Judd goes BERSERK on Chicago PD for abandoning federal agents after a terror attack this weekend. 🔥

"Let me say this, for other law enforcement leaders across this state and nation: you need to be standing UP saying the SAME EXACT THING that I am. Because when you have a breakdown of the rule of law, when you allow anarchist criminals to take over the streets and attack law enforcement officers and then not send them help? That's a slippery slope, a REAL slippery slope."

"Let me give you the antithesis of this. We had a single man resist ICE agents and get away from them in our community. We sent a helicopter, a drone, canine, and 50 law enforcement officers to surround an area and we found that guy who violently resisted ICE and we locked him up in jail where he should have been."

"I have NEVER heard of one law enforcement agency not helping another when they call for help until this weekend, when a chief of patrol for the Chicago Police Department instructed the police officers not to run in and help their colleagues who were calling for help, who were under attack by a bunch of people clearly violating the law!"

"If you allow anarchists and criminals to run wild in your community, people will die. People will be shot."

[Tim Kennedy @TimKennedyJr1]

Multi-storey Charlie Kirk banner being hung outside @Heritage ahead of Sunday’s memorial service in Arizona.

The quote: “Get married. Have children. Build a legacy. Pass down your values. Purse the eternal. Seek true joy.”

[Charlie Kirk @charliekirk11]

Today is the beginning of June. Any “celebration” that includes half-naked men whipping each other in the streets, in front of kids, is morally repugnant and nothing more than an excuse to normalize putting creepy sex fetishes on public display. This is wrong and should stop.

Most people can accept that two adults have freedom in the privacy of their own home. But Pride has become a public coercion campaign forcing the rest of us, even children, into celebrating alongside and eventually participating with the Alphabet Mafia under threat of being found guilty of “hate.” It’s cultural tyranny.

No more.

It’s well past time we prioritize common decency, good public behavior, and the innocence of children again.

Let’s make June great again.