Christophe Rossier

Pharmacien, entrepreneur, joueur de tennis, coureur, trailer, bonsaïka, globetrotter.
@[email protected]

[Christophe Rossier @ChRossier]

@BrunoTertrais 😂

[Christophe Rossier @ChRossier]

@BrunoTertrais Il y a une variable que vous n'avez pas évoquée, c'est la perspective des midterms aux USA. Ne pensez-vous pas qu'elle modifie les probabilités des différents scénarios (notamment du quatrième) ?

[Peter Baker @peterbakernyt]

A @politico analysis finds that judges have ruled against ICE detention practices some 10,000 times, or roughly 90% of cases, since the agency mandated that millions of immigrants must be locked up while they face deportation proceedings. @kyledcheney https://t.co/vGqKJwjlrr

[Christophe Rossier @ChRossier]

@ClaudeSteve6 😂

[Christophe Rossier @ChRossier]

@Fraslin @ClaudeSteve6 En espérant que ça ne mènera pas les personnes concernées à se contenter d'une seule vaccination Covid par année, puisqu'on sait que la protection conférée par le vaccin s'étiole assez rapidement... 😬

[Christophe Rossier @ChRossier]

Huge ! 😂

[David Rangl @rangl_david]

Z toho bude skvělý virál‼️😂👍

Donald Tusk 🇵🇱 si libuje, že po dlouhých letech nebyl na jednání špiček EU 🇪🇺 žádný rusák 🇷🇺😂

Když tu do záběru vleze Robert Fico 🇸🇰 a z davu se ozve….”jste si jistý⁉️”😂

Výraz Donalda Tuska si nekoupíte na vše ostatní je zde SberBank 😂

[🅶🅾🆁🅺 @Raclure03]

Même la flûte elle savait pas qu'elle pouvait faire ça 😱😱😱

[Christophe Rossier @ChRossier]

Truly amazing !

[Veera Rajagopal  @doctorveera]

A monumental moment in medical history: the first gene therapy for genetic hearing loss is now FDA approved. As a former Regeneron scientist, I feel very proud. I had the opportunity to hear about this programme while it was still in development. It’s one of the few programmes that, every time you came across it, you felt the medical breakthrough in your bones and privileged just to be there while it was happening.

At this moment, it’s important that we look 30 years back when researchers mapped a locus on chromosome 2 to congenital deafness in a Lebanese family (https://t.co/o8ltjHyLNy). They named it DFNB6 (later DFNB9) with no clue about the responsible gene. Three years later, the causal gene came to light: OTOF, encoding a protein called otoferlin (https://t.co/tBGlFPzaQd). Seven years after that, in 2006, pioneering work by Christine Petit revealed that otoferlin is a calcium sensor in the inner hair cell membrane, acting as a molecular trigger that converts sound into electric signals that the brain can read (https://t.co/oxXtifPrTZ). Twenty years fast forward, we now have a successful treatment. Thirty years from discovery to medicine.

OTOF-related deafness is congenital, caused by complete deficiency of otoferlin. In these children, the cochlea is structurally intact, hair cells are there, the mechanics of sound transmission work. It’s just that final step, where hair cells hand off the signal to the auditory nerve through neurotransmitter release, that doesn’t happen. Sound arrives and dies at the synapse. It’s deafness due to a defect in the synapse caused by the absence of a single protein, which is what made this a beautiful, clean target for gene therapy.

The treatment itself is a feat of molecular engineering. OTOF is too large to fit in a single AAV capsid. The team solved this elegantly by delivering the gene in two halves separately, which then get spliced to produce the full functional protein. A single surgical injection into the cochlea, a molecular miracle unfolds. Results from the CHORD trial were striking: of 20 evaluable patients, including children as young as 10 months, 80% showed meaningful hearing improvement, and by 48 weeks, 42% had achieved normal hearing including the ability to hear whispers. Otarmeni is not only the first gene therapy for deafness, it’s also the first dual-AAV therapy to be approved by the FDA.

There are very few things in medicine that come close to giving back a sense like vision, hearing, or touch that a human never had from birth. It’s almost God’s work. A parent witnessing their child who was born deaf hearing their voice for the first time, it’s a joy that no words can describe. Multiply that by the fact that it came from a single injection, a repaired gene, and 30 years of science. We are truly in the golden era of medicine.

Regeneron press release:
https://t.co/6zvdsT2uzI

Below video is from the NEJM publication of CHORD trial (Valayannopoulos et al. NEJM 2025)
https://t.co/YvIqwQ0SDu

[Timothy Snyder @TimothyDSnyder]

Very serious point here — media vastly overreport what Trump says rather than clarifying for the reader the actual strategic situation.

[Bruno Tertrais @BrunoTertrais]

Dans ⁦@LePoint⁩ cette semaine, enquête sur l’administration américaine la plus corrompue depuis… la révolution ?

[Anne Applebaum @anneapplebaum]

Trump has insulted and tariffed his European allies, persuaded Denmark to prepare for a US invasion and, by pressuring Ukraine and not Russia, encouraged Putin to keep fighting. All of which he has forgotten.
https://t.co/GhDO27FyxK

[Christophe Rossier @ChRossier]

@TheoLaubry Tout ça quelques heures avant que la Suisse sorte la France de l'Euro ? 😉

[Christophe Rossier @ChRossier]

@TheoLaubry Attention aux commentaires imprudents sur l'équipe de Suisse 😉 ! Dois-je vous retrouver la vidéo ou un ancien sélectionneur disait en direct que pour que la Suisse ait une chance face à la France, il fallait que cette dernière reste bloquée dans l'ascenseur ?

[Christophe Rossier @ChRossier]

@TheoLaubry Et AOC ? Peut-être pas comme présidente, mais au Congrès ?

[Christophe Rossier @ChRossier]

@ATLBlackStar @shannonrwatts These guys seem so poorly trained 🙄... Very sad story (again) 😢

[Noah Smith 🐇🇺🇸🇺🇦🇹🇼 @Noahpinion]

Some things all incels should realize:

1. There is no single answer to "what women want". Different women like all kinds of different things. There are a few things that lots of women want, and guys tend to focus on those few things. But these are only part of what women care about -- sometimes a surprisingly small part. The rest is very bespoke and often kind of weird. "There's somebody for everybody" isn't literally true, but it's kinda true.

2. One thing lots of women want from a man is companionship, and this has nothing to do with status or looks or money. This is why basically any guy can get a girlfriend. Sure, being hot and popular makes it easier, but it's very possible for basically any guy.

3. One thing most women want is a guy who's good in bed. Basically any guy can become good in bed, through practice and paying attention and caring about their partner(s).

4. Incel ideas are not new. They are not recent reactions to dating apps or wokeness; they are very very old expressions of male sexual frustration. You can read guys saying very similar things throughout history. And yet in recent centuries, almost all men managed to reproduce.

5. It's natural to want to get together with the boys and complain about women. It's a male bonding activity. Women do the same thing when they get together and complain about men. Just remember that this sort of bullshit, where you bash the other gender for being a bunch of hos or shallow or whatever, is for same-sex friendship bonding; it doesn't reflect reality. Most women, like most men, are basically good people.

6. As a man, it's important to think about what you want from women. Lots of guys assume they want to be a chad who bangs all the girls. And for some people that lifestyle is fun and fulfilling. But most guys wouldn't actually be happy with that. So just because every girl on the block isn't lining up to bang you doesn't mean you're a loser.

7. The media, which includes social media and influencers and so on, is always trying to sell you bullshit -- you're not hot enough, you're not rich enough, etc. -- in order to get your eyeballs and clicks and if possible your dollars. The media does not have your best interests in mind. The media does not want you to know how easy it is to live a pretty good, normal life, because if you knew, you would just go do it, and you'd stop paying attention to the media.

(Why am I different? Why will I tell you the truth? Because I get clicks and eyeballs from talking about economics. I don't need to be a lifestyle influencer or self-help guy. I am only writing this long-ass tweet in order to procrastinate doing my actual job. Take it or leave it, but I'm right about all of this.)

[Christophe Rossier @ChRossier]

@lactetue @WilliamReymond @Maintenantoff @bluetouff Question : j'apprécie aussi William Reymond, mais n'ai absolument pas le temps d'écouter ses longues vidéos, qui dépassent souvent une heure, plusieurs fois par semaine 😬. Comment faites-vous ? Avez-vous un truc ?

[Christophe Rossier @ChRossier]

@lauremandeville À sa place je ne serais pas tranquille de partager mes technologies avec l'équipe de Trump, qui est une passoire �� infos confidentielles. Et connaissant leurs liens avec la Russie... 🤔

[Christophe Rossier @ChRossier]

Trump Promised the ‘World’s Lowest’ Drug Prices. We Checked the Numbers. https://t.co/Ok24IodIZr

Spoiler alert : they are still among the highest in the world !

[Christophe Rossier @ChRossier]

@ClaudeSteve6 Devant ton ordinateur ! 😉