CIS

The Clinical Immunology Society (CIS) aims to support & advance the community of immunology.

[CIS @ClinImmSoc]

In early August, CIS Leadership again met for their annual retreat at the CIS Headquarters in Milwaukee!

The 2026 Leadership Retreat provided a chance to build bridges, share vision, and celebrate the unwavering commitment that drives the Clinical Immunology Society forward.

[CIS @ClinImmSoc]

Access ready-to-use advocacy letter templates in the Members Only section

Access here: https://t.co/5uI531p2Ot

Disclaimer: These templates serve as guidelines only. CIS is not responsible for financial or clinical outcomes resulting from their use.

[Journal of Human Immunity @jhumimmunity]

Gaufryau, Stolzenberg, @JRosain et al. report a deep intronic #FOXP3 pathogenic variant that was investigated by RNA sequencing in heterozygous female carriers. https://t.co/TJ4P7g4hgl

#Atopy #Diagnostics #Autoimmunity #InbornErrorsOfImmunity #IPEX

[Journal of Human Immunity @jhumimmunity]

Lévy, Raedler, Hauck et al. show that allogeneic #HCT substantially addresses #immunodeficiency, immune dysregulation, & Epstein-Barr virus–positive smooth muscle tumors in patients with CARMIL2 deficiency and should be offered shortly following diagnosis https://t.co/ILHYDqHdwR

[Journal of Human Immunity @jhumimmunity]

APDS is a rare inborn error of immunity classified as a group of combined #immunodeficiency; however, because specific treatments for APDS are available, early diagnosis and therapeutic intervention are crucial for improving patient prognosis. (1/2) https://t.co/DKVC1aPxVQ

[Journal of Human Immunity @jhumimmunity]

Does CVID exist in children? @ESIDsociety registry analysis of 7,525 CVID patients shows age-dependent enrichment of monogenic #IEI in pediatric and early-onset CVID-like disease, supporting genetic testing and longitudinal reassessment. https://t.co/vQx6JWcBOg

[Journal of Human Immunity @jhumimmunity]

This case report from Shin, Lyons et al. @UCSanDiego describes progressive multifocal leukoencephalopathy in a patient with ADA-#SCID who received early #GeneTherapy, highlighting the importance of lifelong monitoring after early gene therapy protocols. https://t.co/GZDsVgnLWz

[Journal of Human Immunity @jhumimmunity]

New review by Jolles et al. considers the utility of calculated globulin as an unbiased & inexpensive screening tool for #immunodeficiency. The benefits and practicalities of its clinical implementation and current challenges and limitations are discussed. https://t.co/xylkxLtf56

[Journal of Human Immunity @jhumimmunity]

Duintjer et al. demonstrate that second-tier genetics improves newborn screening accuracy for #SCID and other T cell deficiencies. A safety net algorithm maintains high sensitivity for SCID while substantially increasing the PPV from 22.1% to 55.2%. https://t.co/J7gypFFt4f

[Journal of Human Immunity @jhumimmunity]

🔔 We're delighted to share the Abstracts from the Primary Immune Deficiency Treatment Consortium #PIDTC (@PIDTC52138) Annual Workshop, which took place this March in Salt Lake City. Explore the latest advancements in #PID clinical practice & research! 👉 https://t.co/BzdZiQeD2f

[Journal of Human Immunity @jhumimmunity]

Prunotto, Lucchini et al describe clinical presentation, immunological status, treatment, & long-term outcomes of a large cohort of pediatric and adult patients affected by an extremely complex and rare immunodeficiency known as #TTC7A deficiency. https://t.co/8ExyJHowTZ
@TheEBMT

[Elie Haddad @ElieHaddad55]

Universal newborn screening reduces survival disparities related to race and ethnicity after HCT for SCID. This is an important study from the PIDTC that has just been published in the Journal of Human Immunity. Another good reason to spread NBS for SCID all over the world! @pidtc52138 @jhumimmunity @ClinImmSoc

[Journal of Human Immunity @jhumimmunity]

In a @PIDTC52138 cohort of 796 patients, Black patients w/ #SCID had >2× higher hazard of death after non-sibling HCT. #NewbornScreening eliminated these #disparities. Early detection saves lives & promotes #healthequity. By @drlenawine @ElieHaddad55 et al https://t.co/1aa3DKspXT

[Journal of Human Immunity @jhumimmunity]

Autosomal recessive #CGD represents a significant disease in the Middle East & North Africa region associated w/ significant morbidity & mortality. Addressing regional challenges, in prevention, diagnosis and managment is essential to compact the disease. https://t.co/VW4FzkzcuP

[Journal of Human Immunity @jhumimmunity]

Our July issue is here! https://t.co/K0VFE6SGL8
This cover highlights the first human biallelic OSMR deficiency. @TurveyLab et al. show that OSMR deficiency disrupts OSM-STAT signaling, driving severe early-onset #eczema, #eosinophilia, and elevated IgE. https://t.co/CIgQQchDEQ

[Journal of Human Immunity @jhumimmunity]

Kienapfel et al. report the characterization of two novel mutations underlying #STAT2 deficiency in three patients with viral infections & hyperinflammation following live viral vaccines. Beneficial use of ruxolinitib in one patient is also reported. https://t.co/bl1LVuGAKT

[Journal of Human Immunity @jhumimmunity]

.@bogunoviclab et al. show that, in a neonate with a DOCK11 variant of uncertain significance, negative functional studies guide clinical care, highlighting the broader value of publishing instructive negative findings in immunology & genomic medicine https://t.co/GUHPFXnpU5

[Journal of Human Immunity @jhumimmunity]

In this first randomized, placebo-controlled trial by Toshinao Kawai et al. @ncchd_pr, #thalidomide demonstrated potential efficacy & acceptable safety in patients aged 1 year or older with chronic granulomatous disease–related inflammatory bowel disease. https://t.co/DH03vfltsG

[CIS @ClinImmSoc]

The Deadline is Here!

Applications are now due by tonight, Monday, July 6th at 11:59PM EDT!
When and where: October 22-25 in Fort Lauderdale, Florida

🔗 Learn more & apply now! https://t.co/A5CtyCwnXp

Questions? Reach out to Ashley Knight at [email protected] See less

[CIS @ClinImmSoc]

Applications have been extended for the 2026 CIS Summer School!

Applications are now due by Monday, July 6th at 11:59PM EDT!

🔗 Learn more & apply now! https://t.co/A5CtyCwnXp
Questions? Reach out to Ashley Knight at [email protected]