COIOSCatalyst

New research on the drivers of future health and mortality risk, summarised daily with its figures. Free twice-weekly digest at

[COIOSCatalyst @COIOSCatalyst]

Temperature and mortality across 3,116 Dutch districts, 2010-2019: cold was associated with 11,988 excess deaths a year, heat with 346.

https://t.co/XoSEtLzHnL

[COIOSCatalyst @COIOSCatalyst]

Type 2 diabetes remission in routine care: recorded in 3.82% of previously treated adults within five years. First remission lasted a median 226 days and ended more often with a treatment restart than with rising HbA1c. (@medrxivpreprint)

https://t.co/22TSgffKsr

[COIOSCatalyst @COIOSCatalyst]

Social-needs codes in US health records: across 21 health systems, a first Z59 hardship code was followed by 67% more emergency visits. An administrative code with no hardship meaning reproduced 46% of that association. (@medrxivpreprint)

https://t.co/R0Ih4D9324

[COIOSCatalyst @COIOSCatalyst]

Enzalutamide in metastatic hormone-sensitive prostate cancer: in the ENZAMET trial, adding it cost AUD$835,580 per QALY gained, with a 6% probability of being cost-effective at AUD$50,000 per QALY.

https://t.co/tNdWGYjH3T

[COIOSCatalyst @COIOSCatalyst]

Measles in US counties: since 2021, counties with lower vaccine coverage have had larger outbreaks, and spread to neighbouring counties has increased. Before 2021 the association was weak and outbreaks mostly stayed within one county. (@medrxivpreprint)

https://t.co/lvWvXw6m67

[COIOSCatalyst @COIOSCatalyst]

Type 2 diabetes in one Israeli health system: median age at diagnosis rose from 63.0 to 66.7 years between 2005-2008 and 2020-2023, and the Charlson comorbidity score from 4 to 6.

https://t.co/gTqqXS3Ojc

[COIOSCatalyst @COIOSCatalyst]

Death recording in OpenSAFELY-TPP primary care records: of 1,409,275 ONS-registered deaths from 2020 to 2025, 88% had the same date of death in primary care and 8% had none. (@medrxivpreprint)

https://t.co/7FRRTOfCAf

[COIOSCatalyst @COIOSCatalyst]

Wildfire smoke and mortality in US counties: excess deaths peaked about three years after exposure. The authors estimate 1.7 million smoke-associated deaths in 2011-2023, about ten times the estimate from ambient PM2.5 relative risks. (@medrxivpreprint)

https://t.co/JU3FdVprG3

[COIOSCatalyst @COIOSCatalyst]

Health opportunity costs in 92 low- and middle-income countries: the re-estimated marginal cost per DALY averted ranges from about $54 to $18,547. It was higher than Ochalek et al. (2018) in 68% of countries. (@medrxivpreprint)

https://t.co/3PcAcHs3lP

[COIOSCatalyst @COIOSCatalyst]

NHS online self-management for type 2 diabetes: a UKPDS-OM2.1 model put Healthy Living at £13,192 per QALY, below the £25,000 NICE threshold. The gain was 0.016 QALYs per user.

https://t.co/grvCMF0rpO

[COIOSCatalyst @COIOSCatalyst]

CYP2D6 and metoprolol in 44,485 All of Us participants: poor metabolisers had lower heart rate and more bradycardia (OR 1.19), but were no more likely to stop the drug (HR 1.04).

https://t.co/KzkTub4xDB

[COIOSCatalyst @COIOSCatalyst]

Opioid agonist treatment in Austria: among 26,031 people in the national registry, all-cause mortality was 7.06 times the general population rate in women and 3.86 times in men. Viral hepatitis gave the highest SMR, 63.8.

https://t.co/1QUNR2P29J

[COIOSCatalyst @COIOSCatalyst]

Dementia incidence across 22 cohorts in 18 countries: 9.7 per 1000 person-years, age- and sex-standardised. It was 13.6 in low- and middle-income countries against 8.3 in high-income countries.

https://t.co/AhnVQ1vC6J

[COIOSCatalyst @COIOSCatalyst]

Tirzepatide price rise in the UK: among 1,033,522 self-paying adults, semaglutide initiation rose 31 percentage points in September 2025, the month tirzepatide's list price rose. Switching to semaglutide rose 9 points.

https://t.co/WXdXMI6nmV

[COIOSCatalyst @COIOSCatalyst]

Psychiatric illness and life expectancy in Queensland: among 255,448 adults admitted 2009-2023, the gap at age 18 fell from 16.7 to 12.1 years in men and from 13.4 to 9.4 in women. It did not narrow in schizophrenia.

https://t.co/QuVmDLz9ui

[COIOSCatalyst @COIOSCatalyst]

Cancer cachexia in routine records: in 52,236 patients, episodes of cachectic weight loss coincided with disease progression and lower survival, and were more common with TP53 mutations. An association, not proof that the weight loss shortens survival.

https://t.co/M0pRHgA2Mz

[COIOSCatalyst @COIOSCatalyst]

Air pollution and memory in England: among 12,235 adults aged 50+, more days above the WHO daily NO2 guideline went with faster memory decline, whatever the annual mean. Days above the PM2.5 and PM10 guidelines showed no link. A preprint.

https://t.co/rNvMeWO72j

[COIOSCatalyst @COIOSCatalyst]

Coronary calcium on routine scans: a deep-learning model tested in 5,969 patients stratified risk of death or heart attack better than experts reading the same scans (net reclassification +0.089). A preprint.

https://t.co/Zd5lzi0WBE

[COIOSCatalyst @COIOSCatalyst]

Hip fracture in UK women: 60 of 99 dietary factors were associated with risk among 541,887 postmenopausal women followed for about 20 years. Protein showed the strongest link with lower risk (HR 0.79 per extra 15 g a day). Causation not established.

https://t.co/8kaAXdpnLE

[COIOSCatalyst @COIOSCatalyst]

Sweden's SIMPLER resource links diet and lifestyle questionnaires repeated since 1987 for 107,000 adults to national registers of diagnoses, medicines and deaths, with genomic data on about 51,000.

https://t.co/FsHXW8Ai1T