Losing a loved one is incredibly hard, especially when unexpected expenses arise. A GoFundMe has been set up to help cover my mother’s funeral costs after her passing. Any support you can offer, whether through donations or sharing would be appreciated https://t.co/uhC0zLAtJV
A new shot literally regrows knee cartilage.
Researchers at Stanford Medicine have identified a novel strategy to regenerate articular cartilage in knees and potentially prevent or treat osteoarthritis (OA).
The method targets 15-hydroxyprostaglandin dehydrogenase (15-PGDH), an age-related enzyme—or "gerozyme"—that accumulates in aging tissues and drives degeneration.
In aged mice, small-molecule inhibitors of 15-PGDH, delivered systemically or via intra-articular injection, promoted cartilage thickening and regeneration of functional hyaline articular cartilage.
This occurred without recruiting stem or progenitor cells; instead, existing chondrocytes underwent transcriptional reprogramming to a youthful state, with reduced populations of inflammatory and hypertrophic/degradative cells and expanded matrix-producing articular chondrocytes.
The inhibitors also reversed natural age-related cartilage thinning, improved joint function, and—when administered after simulated ACL injuries—strongly mitigated post-traumatic OA progression and associated pain.
Human OA cartilage explants from total knee replacements responded similarly in vitro, showing decreased degradation markers and evidence of new articular cartilage formation.
Given that an oral 15-PGDH inhibitor has already completed Phase 1 safety trials for age-related muscle atrophy, the findings open a path toward disease-modifying, regenerative therapies that could delay or obviate the need for joint replacement surgery.
[Agarwal, P., Su, S., Ancel, S., et al. (2025). Inhibition of 15-hydroxy prostaglandin dehydrogenase promotes cartilage regeneration. Science. DOI: 10.1126/science.adx6649]
🚨 Anthropic just showed a 24-minute workshop on how to actually do prompts for Claude.
Taught by the people who built it.
Free. No registration. No paywall.
I've seen $300 courses that don't cover what they teach in the first 8 minutes.
Watch it and bookmark it now.
BREAKING: In a stunning admission, Mike Johnson just told reporters that he has plan to cut Medicare and Medicaid after the midterms. We can stop this by making Hakeem Jeffries the next Speaker of the House.
This is so insanely corrupt, I can’t even believe it.
More than half the donors to Trump’s $400 million White House ballroom just won over $50 billion in new federal contracts in six months.
And here’s the part that should make your blood boil.
Sixteen of these 27 donors were facing federal enforcement actions, antitrust reviews, labor cases, securities charges. Many of those cases have been quietly dropped or scaled back since Trump took office. You write a check, your legal problems disappear. That’s not a coincidence.
The White House won’t even release the full donor list. They’re hiding it on purpose, because daylight is the one thing pay-to-play can’t survive. A federal judge already ruled ballroom construction has to stop until Congress authorizes it.
Government is supposed to serve the people, not auction itself off to the highest bidder. When access goes to whoever pays the most, working families always end up paying the price.
We either end the corruption, or the corruption will end us.
https://t.co/4MGFzSseFl
I am proud and thankful to have served in the U.S. House of Representatives with my friend Thomas Massie, a giant among weak pathetic men.
Releasing the Epstein files was our demise.
But it was worth every single bit because now everyone knows the truth.
You are ruled by the Epstein class that cares nothing about you and your elected leaders are bought and controlled by a foreign lobby.
Tonight the future of the Republican Party was destroyed.
The Real America First Movement will rise led by the younger generations, who hate the old guard with an unquenchable passion.
Let us pray that we have a country left by the time these creatures are gone.
Yes, 3 facepalms 🤦🏻♀️🤦🏻♀️🤦🏻♀️
Do these people have actual brains in their heads or is it just filled with air?
Sure, she is definitely owning the libs!
I’m owned!🥴
Elon Musk called Hitler a socialist then Grok correctly debunks him by pointing out Hitler rejected Marxism and ran a fascist system that prioritized nationalism and private enterprise. Grok then explains socialism is class equality and worker ownership!
Never deleting this app.
🚨 Marjorie Taylor Greene just confirmed what many of us have suspected.
The eight-week government shutdown was orchestrated by Trump to prevent the release of the Epstein files.
MTG said it.
Not a journalist. Not a Democrat.
His own ally.
The same files Pam Bondi is in contempt of Congress for hiding.
The same files the DOJ inspector general is now investigating.
The same files the war was started to bury.
It was never about the budget.
Never stop connecting the dots.
Trump just said:
“When I get out of office in, let’s say, eight or nine years from now…”
His current term ends in 2029.
Eight or nine years from now is 2033 or 2034.
The 22nd Amendment limits presidents to two terms.
His own judicial nominees refused to confirm that on camera this week.
He’s not hiding it anymore.
Never stop connecting the dots.
@allenanalysis Because nothing says ‘Make America Great Again’ like burning the agency that manages actual forests. Next up: abolishing the National Park Service because who needs trees when you have golf courses? 😂
Dear Americans,
Iran does not have the missile range to strike your country;
if an attack occurs, it would most likely be carried out by your own GOVERNMENT or ISRAEL.