CSACI NREP

Canadian Society of Allergy and Clinical Immunology National Resident Education Program. Live tweets of the CSACI AGM by NREP participants. Follow along!

[CSACI NREP @CSACI_NREP]

Barriers to not prescribing biologics for severe asthma: time to counsel, need for education on new therapies, fear of term "biologic", experience limitation. Learn from colleagues and engage in shared decision making. Paucity of data in peds but research ongoing! #CSACI23 #NREP

[CSACI NREP @CSACI_NREP]

Excellent talk by Dr. Zuraw highlighting the role of early next generation sequencing as an integral and mostly cost effective part of the angioedema work up. Patients with a strong family history and negative genetic testing does not rule out HAE with normal C1 inhibitor.

[CSACI NREP @CSACI_NREP]

- Unpredictable
- Rare
- Painful swelling attacks in different parts of the body
- Delays in diagnosis/ misdiagnosis
- limited treatment options
These are some factors contributing to the huge psychosocial burden of illness for hereditary angioedema #NREP #CSACI2023 #HAE

[CSACI NREP @CSACI_NREP]

Spleen Tyrosine Kinase (SYK) plays a important role in adaptive and innate immunity. SYK variants have been identified in patients with arthritis, dermatitis, colitis and predisposition to lymphoma. Studies have shown SYK inhibitors and ASCT as potential treatments. #NREP #CSACI

[CSACI NREP @CSACI_NREP]

Severe eosinophilic airway disease in STAT3 loss of function is driven by IL-5, so targeting eosinophils with biologic treatment can be an effective treatment approach. Biologics can reduce the respiratory tract infection burden but the immune defect remains #CSACI2023 #NREP

[CSACI NREP @CSACI_NREP]

Great talk by Dr. Adil Adatia on STAT3 deficiency and other monogenic inborn errors of immunity that cause hyper IgE syndromes! #CSACI2023 #NREP

[CSACI NREP @CSACI_NREP]

Clinical features of STAT3 deficiency incl. infection (chronic mucocutaneous candidiasis & bacterial skin or lung infections), abnormal inflammatory response leading to bronchiectasis & pneumatoceles, atopy (eczematoid dermatitis, asthma), & connective tissue abnormalities

[CSACI NREP @CSACI_NREP]

During the last year, a novel variant, STAT6 gain-of-function, was discovered to be associated with severe atopic disease. #CSACI2023 #NREP #atopy #allergy #eczema #asthma

[CSACI NREP @CSACI_NREP]

Great talk by Dr Catherine Biggs on severe atopic presentations in patients with monogenic disorders of immunity! Red flags for atopic disorders including positive family history, moderate to severe eosinophilia and autoimmunity.

[CSACI NREP @CSACI_NREP]

Canada has shortage of plasma and IVIG and the supply along with not having uniform Indication for using IVIG across Canada is part of barriers to this life saving therapy.
#CSACI2023 #NREP

[CSACI NREP @CSACI_NREP]

Interesting talk by Dr. Mazer on adherence and barrier to immunoglobulin replacement therapy:
Canada is 2nd biggest use per capita of IVIG following behind US, however Canada does not fractionate own product and rely on Europe and US for IVIG products.
#CSACI2023 #NREP

[CSACI NREP @CSACI_NREP]

Did you know? Every 1 year delay in diagnosing Common Variable Immunodeficiency has been associated with a 4-5% increase in the risk of death. This further underscores the importance of early diagnosis and treatment towards successful patient outcomes! 🧬 #CSACI2023 #CVID

[CSACI NREP @CSACI_NREP]

How “Common” is Common Variable Immunodeficiency? As Dr. Betschel currently explains: up to 4000 people in Canada 🇨🇦 may be affected 🧬 #CSACI2023 #NREP #CVID

[CSACI NREP @CSACI_NREP]

Super interesting talk on Eosinophilic Esophagitis (EoE) by Dr. M. Gupta. Did you know that signs/symptoms of EoE can be discordant with the degree of histological changes, and therefore endoscopy with biopsy is the gold-standard for ongoing surveillance of EoE? #CSACI2023 #NREP

[CSACI NREP @CSACI_NREP]

A lot of learning happening during CSACI NREP session on hereditary alpha tryptasemia thanks to Dr Lyons! Did you know that the most common cause (over 90 percent) of an elevated serum tryptase encountered clinically is hereditary alpha tryptasemia?! #csaci2023 #nrep

[CSACI NREP @CSACI_NREP]

Interesting talk shared by Dr. Byrne on idiopathic anaphylaxis and the broad differential to be considered in this challenging diagnosis of exclusion - cofactor dependence, alpha gal allergy, mast cell disorders, eaten wasps?! #csaci2023 #nrep

[CSACI NREP @CSACI_NREP]

What a great talk on autoclaved peanuts which may be a safer way to initiate OIT much like baked eggs and milk! #CSACI #NREP

[CSACI NREP @CSACI_NREP]

Dismissal of risk and lack of understanding from others contribute to the lower health-related quality of life in caregivers for children with food allergy. Advocating for these families is one way we can help make a difference! #CSACI2023

[CSACI NREP @CSACI_NREP]

The CSACI Food Educator Program has now been expanded to include any professionals working in food allergy, not just Allied Health Professionals! #CSACI2023#NREP

[CSACI NREP @CSACI_NREP]

Can we create a hypo-allergenic peanut? Come join us to learn! #CSACI #NREP