Integrative Physiology of Aging Laboratory

The Integrative Physiology of Aging Laboratory at The University of Colorado Boulder. Directed by Dr. Douglas Seals.

[Journal of Applied Physiology @japplphysiol]

Mini-Review by DR Seals et al. (@SannaDarvish @CUBoulder @utexascoe @CUAnschutz @virginia_tech) Early women’s health research on endurance #exercisetraining and #cardiovascular #aging at the University of Colorado Boulder using the #mastersathlete model
https://t.co/UP8oJOnPZE

[Hypertension @HyperAHA]

RESEARCH ARTICLE: Late-Onset Menopause Attenuates Aortic Stiffness in the Postmenopausal Period @KOMurrayPhD @SannaDarvish @ZachSClayton

https://t.co/0i9gnjIj5O

[Kevin O Murray, PhD @KOMurrayPhD]

New publication in the @JPhysiol where we show evidence of lowering mitochondrial oxidative stress to improve physical function in old mice. We also see initial efficacy in humans over the age of 70 (n=5) - but larger follow-up studies are required. Enjoy!
https://t.co/uelEwwx6WI

[Integrative Physiology of Aging Laboratory @CUAgingLab]

Congrats to postdoc @KOMurrayPhD for receiving his K01 award (HL177339) titled "Mitochondria-targeted antioxidant supplementation for improving cerebrovascular function in postmenopausal women"

[Integrative Physiology of Aging Laboratory @CUAgingLab]

Two recent laboratory publications in @AgingCell. Congrats to first and senior authors @KOMurrayPhD, Sophia Mahoney, @ZachSClayton, Matt Rossman, and coauthors

https://t.co/CITylGtZnB

https://t.co/4IJGvgJUdH

[Kevin O Murray, PhD @KOMurrayPhD]

New publication identifying sex differences in vascular function between older men and postmenopausal women with mild kidney dysfunction @ajpheartcirc. Led by @SannaDarvish!

https://t.co/h3XPL6dXRY

[APS EEP Section @APSEEPSection]

🎧 Check out the #Antidoping podcast featuring @KOMurrayPhD, recipient of the PCC-sponsored @APSPhysiology Anti-Doping Postdoc Award! 🏅
Insightful discussion!👇🏻

[Kevin O Murray, PhD @KOMurrayPhD]

New pub alert! Here we demonstrate efficacy of fisetin (a food-derived senolytic) for reducing frailty and improving grip strength in old mice by altering gene expression (p21 & cell senescence markers). Check it out! @ZachSClayton @AgingCell @CUAgingLab
https://t.co/e6z4eXbiGn

[Integrative Physiology of Aging Laboratory @CUAgingLab]

Congrats to Sophia Mahoney and @ZachSClayton et al on their recent short communication published in @AgingCell. They identify the natural senolytic 25-hydroxycholesterol as a potential therapy to reduce aortic stiffening in old mice. https://t.co/QsT6hIn9Fj

[Integrative Physiology of Aging Laboratory @CUAgingLab]

Congrats to graduating lab members Sophia Mahoney (PhD), Ashley Darrah (MS) and Krisha Avalani (MS) for earning their degrees last week. We will miss them and can’t wait to see what they accomplish in the coming years!

[Sanna Darvish, MS @SannaDarvish]

Thank you to the @APSCVSection for the opportunity to be a finalist for the CV Outstanding Graduate Student Award and the stage to present our research @APSPhysiology. This work could not have been done without the support of my mentors who say yes to my crazy ideas

[Integrative Physiology of Aging Laboratory @CUAgingLab]

Congrats to @KOMurrayPhD for winning the @APSEEPSection Partnership for Clean Competition Anti-Doping Postdoctoral Research Award and a successful Sprint Talk! @APSPhysiology

[Integrative Physiology of Aging Laboratory @CUAgingLab]

Sophia Mahoney defended her dissertation in March and was recently awarded second place at the Physiological Omics Trainee session for her presentation on fisetin supplementation and prevention of plasma-induced endothelial dysfunction with aging! @APSPhysiology @PhysiologicalG

[The PCC - Funding Anti-Doping Science @PCCantidoping]

The PCC is thrilled to be working with @APSPhysiology to support Rachel Cottle and Dr. Kevin Murray, winners of the 2025 PCC-sponsored #Antidoping Predoctoral and Postdoctoral #Research Awards! They will be presenting their research at #APS2025 April 24-27th in Baltimore.

[Integrative Physiology of Aging Laboratory @CUAgingLab]

Recent review article on all things cellular senescence, vascular dysfunction and senotherapeutics! a collaborative effort by lab members Sophia Mahoney, @ZachSClayton, and Matt Rossman. Published in @JCA_Journal

https://t.co/lOQB3ShD8o

[The Journal of Cardiovascular Aging @JCA_Journal]

Call for Reading:

Mechanisms of cellular senescence-induced vascular aging: evidence of senotherapeutic strategies
https://t.co/cdfeMf32m8

[Circulation Research @CircRes]

1/6 New @CircRes podcast #DiscoverCircRes https://t.co/DNirrbLBB8! @StHilaireLab chats with @SannaDarvish and Matt Rossman about their study Preservation of Vascular Endothelial Function in Late-Onset Postmenopausal Women (https://t.co/e3KIY0yv4R)! @KOMurrayPhD

[Circulation Research @CircRes]

@SannaDarvish et al found that women who completed #menopause later (>55 yo) have preserved vascular endothelial function due to lower oxidative stress & a more favorable circulating #lipid metabolite profile. Learn more at https://t.co/CnjllCRYAg

@KOMurrayPhD

[CU Anschutz Ludeman Center @LudemanCenter]

According to a study from scientists @CUBoulder and published in the @AHA Circulation Research journal, being older when you finish menopause is linked to a lower risk for cardiovascular disease. Read more about their research here.

https://t.co/AAEEPUY8rN

[APS EEP Section @APSEEPSection]

🚨 Join us for the EEP Trainee Workshop on crafting a research statement, teaching philosophy, and CV!
📍 Hilton Baltimore Inner Harbor - Key Ballroom 10
🗓️ April 26, 10:30 AM - 12 PM
✨ Panelists include:
🔹 Zachary Clayton
🔹 Erica Wehrwein
🔹 Scott Davis
🔹 Jacqueline Limberg