Joe Daccache

Ph.D. Candidate | Naik Lab | Ruggles Lab

[Dr. Shruti Naik @DrShrutiNaik]

@GovKathyHochul @KathyHochul @AlStirpe2022 not a single cancer grants to researchers! It’s compromising patient care, future therapies, and the future of New York. Please Support early stage research through the #BBI

[Joe Daccache @daccacheja]

@YUEXING_1 @DrShrutiNaik 👇👇

[nature @Nature]

Nature research paper: Peripheral immune-inducer dendritic cells drive early-life allergic inflammation

https://t.co/v5NJohp8Om

[Dr. Shruti Naik @DrShrutiNaik]

Our new Nature study, lead by @yuexing identifies a brief early-life window when skin dendritic cells sense common allergens and trigger inflammation right in the skin without migrating to lymph nodes. We define this in-situ activation state as peripheral immune inducer (pii)DC, and show it emerges because of a still-maturing HPA axis and low systemic glucocorticoids. #Naiklab

👉Key takeaways:
1. Early-life immunity plays by different rules. During this window, innate responses to allergens in skin are heighted.
2. Hormones shape immunity in real time. Developmental neuroendocrine states profoundly tune how the immune system reacts, and can set the stage for inflammatory disease.

Thanks our incredible collaborators @niroanandalab @EmmaGuttman @kamalkhanna @Teresalu @Amandalund and others. Our funders @NIAIDNews @NIH @DermalCell @SinaiImmunol @MSHSDerm

https://t.co/Ipqicx4TDo

[Joe Daccache @daccacheja]

Fresh off the press from @DrShrutiNaik and @YUEXING_1 an exciting study that uncovers the complexities of early life immunity. Fantastic work from Yue, looking forward to all the follow up work from these findings 🔬🧬🥳

https://t.co/7KmlC7urcK

[Joe Daccache @daccacheja]

The Naik Lab is #hiring! It’s a great opportunity for someone experienced in molecular biology who is excited to work in a collaborative and supportive environment. Come join the team of @DrShrutiNaik at @IcahnMountSinai 🧬🔬

https://t.co/uo0B5ODxVo

[NY-CURES @NYcures]

🚀 NY-CURES Launch — Championing State-Wide Investment in Science! 🚀

We advocate for sustained public support of New York’s biomedical ecosystem — creating therapies, economic gains & strengthening communities.

Sign up. Stay informed. Join the movement: https://t.co/mBLu7M5Lry

[Joe Daccache @daccacheja]

Interested in Inflammatory Memory? Want to learn more about a seminal paper that redefined our understanding of immunology? Check out @DrShrutiNaik and I’s Pillars of Immunology article on Foster, Hargreaves, and Medzhitov’s landmark 2007 Nature study
https://t.co/NInrEhWZdV

[Joe Daccache @daccacheja]

@thomasconway11 @DrShrutiNaik @SinaiImmunol @MSHSDerm Thanks Tom!!!

[Joe Daccache @daccacheja]

Thrilled to have had my F31 funded by the NIH! With the amazing mentorship of @DrShrutiNaik and #KellyRuggles, I’m excited to push our knowledge of inflammatory memory forward and tap into the potential of this field! @SinaiImmunol @MSHSDerm

[Dr. Shruti Naik @DrShrutiNaik]

Congrats to superstar Joe Daccache on his NIH F31 NOA! He aims to define tissue-wide disease memory in inflammatory conditions to develop next-generation therapies. #Naiklab #Ruggleslab @SinaiImmunol @MSHSDerm

[Joe Daccache @daccacheja]

@KoniecznPiotr Thanks Piotr!

[Dr. Shruti Naik @DrShrutiNaik]

9 more days to register for a poster for the innate immune memory kestone! Keynote by ⁦@BelkaidLab⁩ with awesome talks by ⁦@MihaiNetea⁩ ⁦@BrodinPetter⁩ ⁦@JosefowiczLab⁩ ⁦@KathrynMooreLab⁩ ⁦⁦@MazDivangahi⁩ and more!!! ⁦⁦@KeystoneSymp⁩

[Joe Daccache @daccacheja]

Happy to share my first FA paper published in @jacionline this month! Led by @billdamsky , we profiled cutaneous granulomatous disorders using Visium, and found some fascinating insights into their molecular and spatial properties. Check it out!

[Journal of Allergy and Clinical Immunology @jacionline]

Noninfectious inflammatory cutaneous granulomatous disorders share macrophage-predominant inflammation, but why does the inflammatory architecture vary among conditions? Read new data on underlying molecular profiles here. https://t.co/OatbQBKO7I

[Dr. Shruti Naik @DrShrutiNaik]

Fantastic Naik lab warming party in Central Park to celebrate our lab move to Mt Sinai! Thanks to Kate Gaines and @daccacheja for the dope keg tent and awesome spread. @MSHSDerm @SinaiImmunol #scienceandsun

[Joe Daccache @daccacheja]

@KoniecznPiotr @UCIBioSci @UCIrvine @DrShrutiNaik @theLundLab @niroanandalab Congrats Piotr! Excited for you to start a lab and all you will do 🥳🧪

[Piotr Konieczny @KoniecznPiotr]

After 5 years in NYC, I am happy to announce that I will be moving to California to join @UCIBioSci @UCIrvine, to start an Assistant Professor position. This wouldn't be possible without the support of my amazing mentor @DrShrutiNaik, #NaikLab, and @theLundLab, @niroanandalab.

[Ipsita Subudhi @ipsitassubudhi]

Excited to share my first first-author paper in @ImmunityCP! Many thanks to my co-first @KoniecznPiotr, my mentor @DrShrutiNaik, the Naik lab, and our collaborators for helping bring together this story: https://t.co/GFrxkcghNG

[Dr. Shruti Naik @DrShrutiNaik]

Check out the latest from our group aimed at understand how immune cells adapt coordinate metabolism with epithelia to survive in harsh inflammatory environments.⁦@ipsitassubudhi⁩ ⁦@KoniecznPiotr⁩ ⁦@ImmunityCP⁩ https://t.co/0PKlxAN0wr

[Immunity @ImmunityCP]

Online now: Metabolic coordination between skin epithelium and type 17 immunity sustains chronic skin inflammation https://t.co/sasUO145gu

[Piotr Konieczny @KoniecznPiotr]

Check out our new studies published in @ImmunityCP. Big thanks to @ipsitassubudhi, @DrShrutiNaik, and the whole Naik team!
https://t.co/vN9kNpC4VL

[Joe Daccache @daccacheja]

Thrilled to have shared my project with @billdamsky at SID! Had some great conversations about spatial transcritpomics and cutaneous granulomatous disorders. Hopefully we can make some headway in the field with a large unmet need!