Daniel Brat, MD, PhD

Diagnostic neuropathologist and brain tumor researcher @NU_Pathology @NUFeinbergMed @NorthwesternMed

[Leonidas Platanias, MD @LeonidasPlatan1]

When you meet the famous Chair of Pathology today on the bridge connecting the hospital with the research building and you realize he is wearing on his suit the @LurieCancer Center star. @DanielJBrat

[Daniel Brat, MD, PhD @DanielJBrat]

@SachinPatelLab Good man! I went Thursday, 45 years after my first concert (Moving Pictures). New drummer has some mojo!

[Journal of Clinical Investigation @jclinicalinvest]

Can we reverse immunosuppression in glioblastoma?

https://t.co/R2IvPyN8Bd
Jiabo Li @Jason_Li1026, Daniel J. Brat @DanielJBrat & team @NUFeinbergMed discover a pathway that glioblastoma cells use to activate macrophages and suppress anti-tumor immunity, revealing the PDPN-CLEC5A-Syk pathway as a potential therapeutic target.

The image represents the complex cellular architecture and molecular organization of the glioblastoma perinecrotic niche; DAPI (light blue), CLEC5A (orange), VEGFA (pink), CD163 (blue), mCherry (red), IBA1 (green), PD-L1 (purple), CD206 (yellow).
#Glioblastoma #GBM #TumorMicroenvironment #Immunotherapy #NeuroOncology #Macrophages #CancerResearch #BrainTumor #Immunosuppression #Hypoxia
@the_asci

[Journal of Clinical Investigation @jclinicalinvest]

@Jason_Li1026 @DanielJBrat @NUFeinbergMed Combination treatment resulted in the greatest suppression of tumor growth, with smaller tumor volumes compared with single-intervention groups.

[Journal of Clinical Investigation @jclinicalinvest]

@Jason_Li1026 @DanielJBrat @NUFeinbergMed The perinecrotic niche of glioblastoma drives
tumor-associated macrophage polarization and
immunosuppression via podoplanin-mediated CLEC5A
activation: https://t.co/JCSNcyKuMU

[Journal of Clinical Investigation @jclinicalinvest]

@Jason_Li1026 @DanielJBrat @NUFeinbergMed Behind the scenes: Authors Ling-Kai Shih (left), Jiabo Li (middle), and Daniel Brat (right) review unexpected flow cytometric findings related to the expression of CLEC5A by macrophages in hypoxic conditions.

[Daniel Brat, MD, PhD @DanielJBrat]

@AnanBseiso @RokanaTaftaf @NU_Pathology @UChicagoPath Congratulations! We loved having you at Northwestern Pathology and will miss you a lot. Good luck to you.🍀⭐️😍

[Daniel Brat, MD, PhD @DanielJBrat]

Friend and huge contributor to BratLab, Jiabo Li, is going back to China to start career as neurosurgeon-scientist, joining wife Bo, son Samuel and son-on-the-way Daniel. You’ve meant the world to us and we can’t wait to hear all about your growing family and career successes!

[Daniel Brat, MD, PhD @DanielJBrat]

@NeurosurgeryNM Wonderful recognition! Congrats Matt

[Northwestern Pathology @NU_Pathology]

On Friday, our department celebrated our graduating residents and fellows. Congratulations to all of our graduates! We are proud of your accomplishments and wish you all the best in this next chapter💜 #PurplePath

[Jared T. Ahrendsen MD, PhD (AP/NP/FP) @JaredAhrendsen]

What a pleasure it was to celebrate the graduation of @NU_Pathology residents and fellows last night. I am so proud of all the graduates and award recipients. Such bright futures await each of these wonderful #pathologists! #PurplePath

[Northwestern Pathology @NU_Pathology]

We are proud to highlight Dr. Lee Cooper's participation in a highly prestigious session at the 2026 ASCO Annual Meeting focused on translating and validating AI tools into practice in oncology #PurplePath

[Northwestern Pathology @NU_Pathology]

Congratulations to Dr. Sam Weinberg on being named a Hartwell Foundation Investigator! His research on mitochondrial dysfunction and immune disease has the potential to advance treatments for children. We're proud to celebrate this recognition! https://t.co/n4Jr5l7TiA

[Jared T. Ahrendsen MD, PhD (AP/NP/FP) @JaredAhrendsen]

#AANP2026 was fantastic. Highlights included a fantastic platform presentation by @NU_Pathology #neuropath fellow Dr. Melissa Mejia-Bautista, dinner with the Northwestern neuropath division, and seeing many great friends & colleagues. Looking forward to next year! 🧠🔬

[Daniel Brat, MD, PhD @DanielJBrat]

@SenLummis Good luck Dave! You’ll be great in this position and do wonderful things for the US and Australia!

[Senator Cynthia Lummis @SenLummis]

Proud to introduce my friend Dr. Dave Brat as President Trump's nominee for U.S. Ambassador to Australia.

A former congressman, economist, and educator, Dave has proven that good values and sound policy go hand in hand. He is exactly the right person to represent us there.

[Journal of Clinical Investigation @jclinicalinvest]

Uncovering a feedback loop in #glioblastoma that reinforces stemness and immunosuppression: https://t.co/miSHi9vNP7

@DanielJBrat & colleagues @NUFeinbergMed provide a Commentary on Zhou et al.: https://t.co/43Yq4F0Ckg

[Daniel Brat, MD, PhD @DanielJBrat]

Awesome night out on the Rooftop at Wrigley on a chilly evening for Northwetern Neuropathology! Many thanks to our fearless director Rudy Castellani for arranging. Cubs lost, but we outlasted everybody in the stands.

[Daniel Brat, MD, PhD @DanielJBrat]

Interested in diagnosis/management of IDH-mutant glioma patients? cIMPACT 12 proposes evidence-based criteria for IDH-mutant Astro grading that enlarge and homogenize patient cohorts with truly low risk disease by pathology. @NeuroOnc
https://t.co/IEbBIjy3Ww

[Northwestern Pathology @NU_Pathology]

Congratulations to Dr. Tommy Gruchala and Dr. Justin Liu on graduating from the Feinberg School of Medicine! Welcome to the Northwestern Department of Pathology Residency Program. Can’t wait for you to start! #PurplePath