Deeban R, PhD

Medic + PhD @kingscollegelon | AI safety | Sleep Research |

[Deeban R, PhD @Deeban]

Our summary on each RCT to date on hypoglossal nerve stimulation and AHI in Sleep Apnoea.

Good news: consistent AHI reductions, strong safety, durable 5-year outcomes, and favourable cost-effectiveness.

The caveat: the RCT base is still thin. Small cohorts, responder-enriched designs, and short follow-ups that limit generalisability.

For context, the GLP-1/GIP agonist tirzepatide (SURMOUNT-OSA) showed AHI (apnea-hypopnea index) reductions of -25 to -29 events/h across two phase 3 RCTs. The best HNS trials sit around -14 to -16.

We need more trials, but the direction is promising. Published in @journal_CHEST Open access ↓
https://t.co/3qASJONXGk

@KingsCollegeLon @GSTTnhs

[Hunter Biden @HunterBiden]

@Samwise_Ganji Fiat is a sham, the banking class is corrupt, decentralized digital currency and the blockchain are the inevitable future, and the incumbents will fight it to the death.

[Deeban R, PhD @Deeban]

@WiseBaldy @Kellykellam @MarioNawfal 🙏

[Deeban R, PhD @Deeban]

Always great speaking with @Kellykellam. A few points, amongst other things, that we touched upon during @MarioNawfal's roundtable :

- Inherent risks that arise from pre-training
- Failure modes in clinical medicine
- AI hype cycle or scaling cycle

[0xMarioNawfal @RoundtableSpace]

PARTNERED SHOW: Why AI Compute Needs Crypto? w/@Voranofficial https://t.co/o1nScoE6PS

[Deeban R, PhD @Deeban]

@0xGSD @Kellykellam @MarioNawfal Thanks man 👊

[Deeban R, PhD @Deeban]

@amirsaysX @aiedge_ @elonmusk 💯

[Deeban R, PhD @Deeban]

The concerning part is, the fumble is the safer part of the failure. It’s the rationale that should bother you.

It’ll build a clean, plausible reason for the wrong answer - trying to be convincing while wrong.

[Deeban R, PhD @Deeban]

OPUS4.8 High.

Corrected the fact then proceeds to hallucinate the rationale with something that sounds entirely plausible to someone who isn't paying attention.

Weird.

[Irushi @Im_IrushiK]

Opus 4.8 is insane, nothing will be the same after this model 💀

[Deeban R, PhD @Deeban]

@KevyQian @opus_zhen Good times

[Deeban R, PhD @Deeban]

@woodtallica 😅

[Deeban R, PhD @Deeban]

@0xGSD Would help yeah

[Deeban R, PhD @Deeban]

@Im_IrushiK The risks will always be there too - if / when the models jailbreak.

[Deeban R, PhD @Deeban]

@MikushRab Out of interest how are you using it for CAD

[Deeban R, PhD @Deeban]

@randomname2165 @hqmank Agree with this.

[Deeban R, PhD @Deeban]

@hqmank Disagree actually, surprised at the 4.8 hate.

[Deeban R, PhD @Deeban]

@xoaanya Haiku extended 😂😂😂

The worst is it deciding to go “nuclear” when it can’t build it.

Classic Haiku.

[Deeban R, PhD @Deeban]

@Im_IrushiK Yeah, insane.

[Deeban R, PhD @Deeban]

@CliveWardauthor Jutland

[Reads with Ravi @readswithravi]

Marcus Aurelius wrote this over 1800 years ago:

“Until death, all defeat is psychological.”