The Mad Scientist

[The Mad Scientist @DevonCourts]

**Why Cancer Cures Were Delayed by Red Tape**

Cancer reprogramming, using CRISPR and PSC-derived organoids, could have transformed treatment long ago, but regulatory hurdles stalled progress. Here’s how reduced red tape could have led to effective cancer cures, tied to our discussion on reprogramming and KAIST’s colon cancer work.

- **Tech Existed for Decades**:
- CRISPR (2012) and earlier gene-editing tools (1990s) enabled targeting cancer mutations.
- PSC organoids (2000s) allowed human-relevant testing, like KAIST’s 2024 colon cancer reversion (MYB, HDAC2, FOXA2).
- Lab-grown blood/tissues (2010s) offered ethical testing platforms.

- **Red Tape Slowed Progress**:
- FDA/EMA’s 5–10-year trial requirements delayed therapies like KAIST’s reversion.
- Therapy tweaks need re-approvals, stalling innovation.
- High costs ($1–2B/drug) deter investment in novel approaches.

- **Impact of Less Red Tape**:
- **Faster Trials**: Organoid data could cut timelines by 50%, enabling human trials by mid-2010s.
- **Wider Reach**: Rapid testing on organoids could extend reprogramming to breast, lung cancers.
- **Personalized Therapies**: Patient-specific organoids could tailor treatments, speeding delivery.
- **Cheaper Treatments**: Lower regulatory costs via organoid testing would improve access.

- **Missed Opportunities**:
- Reprogramming could have achieved 90–98% early-stage survival rates by now.
- Could have replaced chemotherapy with targeted reversion, reducing side effects.
- Lab-grown blood could have ensured safe integration, bypassing animal tests.

- **Why Delays Persist**:
- Early gene therapy failures (e.g., 1999) led to strict safety rules, overcomplicating approvals.
- Bureaucracy prioritizes exhaustive data over innovation.
- Focus on profitable diseases sidelines rare cancers.

- **Path Forward**:
- Push for organoid data in regulatory approvals to skip lengthy trials.
- Standardize global regulations for faster therapy rollout.
- Fund PSC research for scalable, affordable cures.

**Conclusion**: CRISPR, organoids, and lab-grown blood could have made cancer manageable years ago, with reprogramming potentially curing many types. Red tape, though safety-driven, delayed progress. Streamlining approvals with organoid data can unlock cures faster and equitably.

[British Intel @TheBritishIntel]

🇬🇧 CONVENT AND ST PATRICK BURIAL SITE BURN DOWN IN DOWNPATRICK, MEDIA SAYS NOTHING

Yesterday the convent and the burial place of Saint Patrick himself in Downpatrick was reduced to ashes.

Locals say it was arson. The resting place of the patron saint of Ireland set on fire, and the legacy media has nothing to say. The politicians have nothing to say.

A Catholic site tied to one of the most important figures in the history of these islands burns, and you get silence.

That silence tells you everything.

[The Mad Scientist @DevonCourts]

https://t.co/D4rSzb3BYG

[The Mad Scientist @DevonCourts]

Was it really an accident?

[The Mad Scientist @DevonCourts]

I have been saying this for forever.

[The Reclamare @TheReclamare]

On a claim going back 300 years, in 1912 Canada's highest court upheld that usage of land did not grant Indigenous a right to title, and that 'Settlers' legal title held precedence

Don't know who is arguing the Cowichan/Musqueum/etc claims, but here is link https://t.co/ejxlw4QLC3 @CDNConstFound @JCCFCanada @PharaBoard @timthielmann @KerryLynneFindl

[The Mad Scientist @DevonCourts]

💯

[Max Genest @realmaxgenest]

This Indian migrant in Canada is openly saying the Canadian teenagers killed in the Humboldt Broncos crash by Jaskirat Singh Sidhu, a Punjabi immigrant truck driver, deserved it.

These people slaughter Canadians, celebrate it, and want more murdered.

This is multiculturalism.

[The Mad Scientist @DevonCourts]

@ThorBjornsson_

[The Mad Scientist @DevonCourts]

@Lawton_Braves We appreciate your help.

[The Mad Scientist @DevonCourts]

God bless her.

[The Mad Scientist @DevonCourts]

@Gregoreeee8148 Damaged goods

[Chris Ryan @Watchdog_MP]

🚨 OTTAWA: A historic church built in 1862, just 1.4 km from Parliament Hill, has been turned into a mosque. ☪️🕌

The Imam says it plain:
“We just got a church in downtown Ottawa… We put an offer… now we are in place in the heart of the capital city.” There are now 49 mosques and masjid’s in Ottawa as of 2026.

They’re not hiding the playbook. They’re fundraising off it. Buying up our empty churches as Ottawa brings in the replacement demographic. Planting themselves in the centre of power. Reshaping the country one building at a time.

I never imagined I’d watch our Christian heritage get sold off while Canadians look the other way.

Churches close. Mosques open. Demographics shift with forced government immigration policy. Influence grows.

This is what happens when a nation abandons its foundations. They’re telling you exactly what they intend.

Why do so many still refuse to see it?
#cdnpoli #Ottawa #CanadaFirst #WakeUpCanada ⛪🕌🔥

[The Mad Scientist @DevonCourts]

If the hunger games series was real life.

Ottawa would be the capitol.

[The Mad Scientist @DevonCourts]

Lol slap a camera in the mix, now it’s legal!

[Wall Street Apes @WallStreetApes]

Arizona signs into law HB 2720, this law changes the penalties for both prostitution and paying for sex

These crimes will no longer be misdemeanors, they will be charged as a Class 6 Felony

Fines for a Class 6 Felony are up to $150,000 and up to almost 6 years in prison depending on prior offenses

The new law makes purchasing or offering to pay for sex a Class 6 felony with mandatory minimum jail time: 15 days for a first offense, escalating for repeats, and no probation until served

[IRISH PATRIOT @irishpatriot91]

They actually admit it…

Replacement Migration!

[The Mad Scientist @DevonCourts]

Heck yeah!!

[鈴森はるか 『haruka suzumori』 🇯🇵 @harukaawake]

🇯🇵 Japan is our sacred ancient homeland. This land does not belong to Muslims, communists, or any other group of people who seek to remake it. It belongs to the Japanese people alone.

We will defend our country, our culture, and our future with unbreakable spirit.

[Yossi BenYakar @YossiBenYakar]

A church in Ottawa has been turned into a mosque, and the speaker in the video doesn’t hide a thing. He openly boasts about their rising influence, political reach, and long-term plan to reshape the country.
They are telling you exactly what their movement intends to do.
Why do so many Canadians refuse to see what’s right in front of them?

[Comrade Vanilla @comrade7449]

@nationalpost Imagine advocating for people to off themselves.

Those types of people have zero morals and would sell their mother if given a chance.

[Steve Saretsky @SteveSaretsky]

The condo bailout is also a bank bailout. The fact that governments are pushing these egregiously unpopular policies suggests things are worse than they seem. This feels like Canada’s Big Short moment.

My thoughts: https://t.co/RzzvvM9NTH