Productive evening conspiring against myeloma. This fantastic group accrued >150 patients in MM treatment trials in 2025. Several key colleagues couldn't make to MCO, will join us next year.
@JanakiramMurali@mmejia91@SusanBal9 not surprised. We have not found any benefit of dex or toci prophy in ICANS prevention either with CD19 CAR T. Need mechanistic studies first to define pathophysio of delayed NT before we start planning interventions.
@RahulBanerjeeMD@End_myeloma@bdermanmd@Rfonsi1 As our therapies get better at achieving <10e-6, we will have enough events/power to test these hypothesis. Clearly 2+HRCA is the group where we need better discrimination before de-escalation.
@ChenyuLinMD@VincentRK@RahulBanerjeeMD@Rfonsi1 @TomBmt133 From my limited experience, it seems inferior control arms given rapidly expanding access to CAR and bispecifics. By the time, we open a study, SOC is no longer appropriate for the given population.
Patients with standard risk MM treated with QUADs + ASCT, achieving S-MRD negativity and stopping therapy have <10% risk of progression or MRD resurgence in 4 years!
Join us for the upcoming @TheIACH for Nurses:
Outpatient Bi-Specific Therapy Clinic
with Leslie Mader & Bhagirathbhai Dholaria
🗓️Thursday, May 8 2025
⏲️6pm CET
Register for FREE
⬇️⬇️
https://t.co/P4hRfWKQnR
@lesliemader@DholariaMD@Mohty_EBMT
@bdermanmd@End_myeloma I have noticed this pattern too in last 3-4 yrs. Many requiring steroids. Also, 3 cases of severe auto-GVHD (bx proven) involving skin+ gut. Not sure if there is a pattern here.
📢 Don't miss the next @TheIACH post #ASH24 webinar:
the Most Important Cellular Therapy Studies
🎙️ Speaker: Dr. Bhagirathbhai Dholaria
🗓️ Friday, January 17, 2025
🕔 5 PM CET
🎟️ Register for FREE:
👉 https://t.co/H3BZLB0Auy
@DholariaMD@Mohty_EBMT
@MediHumdani Bi-specifics are currently at a stage where CAR T therapy was in early 2000. They will outpace CAR given ease of logistics, and combinations.
Historic and exemplary!
Congratulations to Gukesh D on his remarkable accomplishment. This is the result of his unparalleled talent, hard work and unwavering determination.
His triumph has not only etched his name in the annals of chess history but has also inspired millions of young minds to dream big and pursue excellence.
My best wishes for his future endeavours. @DGukesh