Amit Sachdev, MD, MS

#Neuromuscular Neurologist #Myasthenia Researcher #Healthcare executive #Dad #Spartan

[Amit Sachdev, MD, MS @DrAmitSachdev]

@UMneurosciences @umichmedicine An amazing teacher. I rely on his clinical skills and acumen today.

[Amit Sachdev, MD, MS @DrAmitSachdev]

"#Satralizumab ... is a humanized monoclonal IgG2 #antibody that binds with #IL6 receptor and inhibits the downstream signalling pathway responsible for #Tcell and #Bcell #activation and B-cell #differentiation [192]." https://t.co/XwQbOquikJ

[Amit Sachdev, MD, MS @DrAmitSachdev]

I found this article to be very useful, keeping track of early phase work in #myasthenia. #neuromuscular #neurology #drugdevelopment

Recent Clinical Trials Analysis on Myasthenia Gravis https://t.co/OMQR071LU4

[Amit Sachdev, MD, MS @DrAmitSachdev]

#TAK079 is being studied in #Myasthenia. Here is some data on tolerability. The broader spectrum of action is potentially useful, but watch those #NKCells! There is a #CD38 agent on market already, so the class is not new. #neuromuscular #neurology

https://t.co/xaRpBE6C3R

[Amit Sachdev, MD, MS @DrAmitSachdev]

#CabalettaBio is working on #Tcell therapies and #myasthenia. They were features in my #MgMI talk on emerging therapies. In particular for super-refractory myasthenia, these are the trials I am thinking of send patients to. #neuromuscular #neurology
https://t.co/oI8c2tZQJR

[Amit Sachdev, MD, MS @DrAmitSachdev]

Unlocking the #immune system to fight #cancer has been a remarkable step in disease management. Applying those lessons to #myasthenia is likely to be an important step.

CAR T-cell Therapy and Its Side Effects https://t.co/2ZFeZ2upq1

[Amit Sachdev, MD, MS @DrAmitSachdev]

#CARTcell therapy in #myasthenia. Very early data suggests tremendous benefit. #neuromuscular
Cartesian Therapeutics to Present Late-Breaking Data from Phase 1/2a Trial of RNA CAR T-cell Therapy in Patients with Generalized Myasthenia Gravis - Cartesian https://t.co/DLNoM6GZ7U

[Amit Sachdev, MD, MS @DrAmitSachdev]

#zilucoplan yielded rapid, clinically meaningful, statistically significant, and sustained improvements in the primary and key secondary end points. I am an author on this study and we have participated in development since phase 2. #myastheniagravis
https://t.co/KpK2aEe13j

[Amit Sachdev, MD, MS @DrAmitSachdev]

"#Complement also seems to be of pathogenic relevance in #neurodegenerative diseases such as #Alzheimer disease"
Complement in neurological disorders and emerging complement-targeted therapeutics | Nature Reviews Neurology https://t.co/ococrolWz7

[Amit Sachdev, MD, MS @DrAmitSachdev]

In the #vegan diet, #b12 vitamin levels need to be considered. #spinach and #beans are often recommended. This paper suggests that #supplements should be considered:

Vitamin B12-Containing Plant Food Sources for Vegetarians - PMC https://t.co/ckXE3LC75y

[Amit Sachdev, MD, MS @DrAmitSachdev]

Media reports suggest colonoscopy is not as effective as previously thought. This interpretation does not appear supported by the authors of the study in question:

https://t.co/i17h2BwOIX

[Amit Sachdev, MD, MS @DrAmitSachdev]

"#PeripheralEdema induced by #gabapentin has been reported to have an incidence of 2% to 8%." I screen for this side effect when I review the drug. #Neurology #Neuromuscular
https://t.co/BTI5y3E2xz.

[Amit Sachdev, MD, MS @DrAmitSachdev]

#MRI Reports say the darndest things! "#AdenoidHypertrophy is an obstructive condition related to an increased size of the #adenoids. The condition can occur with or without an acute or chronic infection of the adenoids. " Lookin at ENT. #medicine #IncidentalFinding #neurology

[Amit Sachdev, MD, MS @DrAmitSachdev]

Delighted to work with Mansur Shaheen/#DailyMail to discuss the claim that abstaining from #alcohol increases the risk of #dementia. "Dr Sachdev wholly declines the findings of the research, saying: ‘I don’t believe that. I don’t believe that conclusion.’
https://t.co/02xAEpLwmA

[Amit Sachdev, MD, MS @DrAmitSachdev]

"#DrugRash with #eosinophilia and systemic symptoms (#DRESS) syndrome is a distinct, severe, idiosyncratic reaction to a drug characterized by a prolonged latency period....clinical manifestations, usually #fever, #rash, #lymphadenopathy, eosinophilia"
https://t.co/KYm4nhKY9F

[Amit Sachdev, MD, MS @DrAmitSachdev]

"#Abstinence from alcohol appears to be associated with an increased risk for all-cause #dementia." Drink less alcohol at your own peril? My first response: total hogwash. My better thought: in this international survey diet isn't American diet

https://t.co/Xzd9Q4500u

[Amit Sachdev, MD, MS @DrAmitSachdev]

" 20 to 30 percent of #prescriptions for #chronichealth conditions are never filled, and about half are not taken as prescribed, according to the CDC."
Why Don’t Patients Follow Their Doctors’ Advice? | AAMC https://t.co/082pvKcKNb

[Amit Sachdev, MD, MS @DrAmitSachdev]

"Approved... in December of 2019, clinicians can use #lemborexant to treat #insomnia in adults....Lemborexant belongs to a class of drugs called dual receptor orexin antagonists" #neurology #sleepmedicine
Lemborexant - StatPearls - NCBI Bookshelf https://t.co/JRGADtr0WR

[Amit Sachdev, MD, MS @DrAmitSachdev]

Thinking about orexin today. "These experiments demonstrate that an #orexin antagonist (SB-334867) reduces food intake and has a greater effect in a rat strain that is susceptible to dietary-induced obesity, than in a resistant strain." #neurology
https://t.co/ALXAC1p1vc

[Amit Sachdev, MD, MS @DrAmitSachdev]

"A peripheral blood #smear should be performed when hemolysis is present ... Hemolytic diseases are classified into #hemoglobinopathies, #membranopathies, #enzymopathies, #immune-mediated anemias, and #extrinsic nonimmune causes. "

https://t.co/j6CHWIwTuy.