Akin Nihat

Neurology Consultant & Senior Research Fellow, MRC Prion Unit. Interested in prions and their suffixes, proteinopathies, neurodegeneration.

[Joel Watts @JoelWattsLab]

Online now in Neuron, the final published version of @xsakuraphie's PhD work on α-synuclein strain generation:

Stochastic misfolding drives the emergence of distinct α-synuclein strains: Neuron https://t.co/SvxrzsKyOZ

[Simon Mead @smead2]

It’s International CJD Awareness Day. https://t.co/SbpW9V45AS

[The Cure CJD Campaign @curecjdcampaign]

12 november: Prion Disease Awareness Day. More to come...

[The Cure CJD Campaign @curecjdcampaign]

🧬 The Cure CJD Campaign launches an international fundraising effort to raise £9 million for Phase II clinical trial of #PRN100 — the most promising treatment ever developed for prion diseases. Read the full Press Release: https://t.co/y9HgNdZmtn

#CJD #PrionDiseases #PRN100

[Simon Mead @smead2]

https://t.co/Bl61D9WmZ3
Recruiting at ST1-ST5 for a resident doctor (neurology, psychiatry, other possible) specialising in prion diseases. Multidisciplinary diagnosis and care of patients with rapidly progressing dementia, integrated with interesting research. Friendly team!

[Simon Mead @smead2]

National Prion Clinic is recruiting a clinical research fellow. suitable for doctors from FY to preCCT. neurology or psychiatry special interest. Learn about rapidly progressive dementia, prions, multidisciplinary community case management, lots of research. Contact me for detail

[Akin Nihat @dranihat]

Very highly recommend working with @DrArpan100, a fantastic colleague and mentor

[𝐀𝐫𝐩𝐚𝐧 𝐌𝐞𝐡𝐭𝐚 @DrArpan100]

Closing 28 Nov 2024. Ideally suited for a postdoc wanting to perform a CRISPR screen in stem-cell derived motor neurons to find new targets for C9ORF72-ALS.

[Michelle Monje 🟦 @michelle_monje]

1/ This is the next chapter of a story about courageous patients and their families, of multidisciplinary teamwork, and hard-fought steps forward to effective therapy for #DIPG #DMG, a universally lethal cancer of the brain and spinal cord. 🧵https://t.co/hMe0XYplKz

[Ruth Dobson @drruthdobson]

Come and help us celebrate the new(ish!) Centre for Preventive Neurology @preventiveneur1 at our launch symposium on 4th March covering early detection and biomarkers, interventions, and addressing inequalities will be covered. Register here https://t.co/cT9QBeOtHa

[Lea Alhilali, MD @teachplaygrub]

1/Keep forgetting what to look for on scans for Alzheimer’s disease?

Do you just gestalt the volume loss & hope no one questions?

Or hope automated software provides an answer?

This week’s SCANtastic 🧵from @theAJNR will show you a better way!

https://t.co/GFAbbW9Tcs

[Nature Medicine @NatureMedicine]

Academic clinician–scientists risk becoming an endangered species.

World View from @StephenORahilly @Cambridge_Uni

https://t.co/J5tnEYlvOQ

[Michael Okun @MichaelOkun]

What is the largest population of people with genetic Alzheimer's? Can the 6 million individuals with Down syndrome obtain access to the new Alzheimer's antibody treatments? NO.
Key points:
- Disease-modifying treatments for #Alzheimer now available.
- Reducing amyloid plaques improves outcomes in early-stage Alzheimer.
- Down syndrome has been excluded from all trials.
- Only handful of any kind of AD treatment trials have included Down syndrome.
- Who is the largest population with genetically determined Alzheimer in the world? Down syndrome.
My take: I agree with the authors that in an era of diversity, equity, and inclusion, let's not leave persons with Down syndrome behind.
https://t.co/GV0Z4LrD3O

[Akin Nihat @dranihat]

Neurologists rejoice, what a fantastic resource

[Genomics Education @genomicsedu]

Our new #neurology #GeNotes resources have been developed in collaboration with #neurologists across the #NHS. From concise summaries based on example clinical scenarios to more in-depth learning, we’ve got your #genomics needs covered. Find out more: https://t.co/2iBpf0Yq8a

[Akin Nihat @dranihat]

@NeilRJWatson1 @smead2 Not many neurologists seem to consider it an option - suspect it's a combination of overemphasis of complications, and underappreciation of how effective it is compared with alternatives - which of course is a vicious cycle if it's never used.

[Akin Nihat @dranihat]

@NeilRJWatson1 @smead2 Last time I saw clozapine used in PD dementia/psychosis (2021), the recommended weekly blood monitoring and bowel side effects seemed quite onerous in this group, esp in the community 1/

[Akin Nihat @dranihat]

🔥🔥

[Simon Ducharme @sducharme66]

New editorial out in Brain:
Brain MRI research in neurodegenerative dementia: time to deliver on promises https://t.co/iiqHLOOs5H

[Akin Nihat @dranihat]

So well-deserved - an absolute pleasure to work with, boundless energy and one of the great neurology polymaths

[UCL Brain Sciences @UCLBrainScience]

Many congratulations to Dr Peter Rudge, who has become an Emeritus Professor of #Neurology at UCL for his outstanding work, particularly as a clinical neurologist with @MRC_Prion 👏👏👏

Dr Rudge has achieved national & international recognition, with over 230 published papers.

[Prof Darrel Francis ☺ Mk CardioFellows Great Again @ProfDFrancis]

Imperial's new Clinical/Academic Cardiology Fellowship

Motto:

"We never forget,
you have a choice"

https://t.co/vtsMU7TyPg

Open to budding cardiologists, and also to existing cardiology SpRs.

[Irina Stefana @irina_stefana]

Do you work in biomedical #research? Do you also question your #antibodies? Dodgy antibodies waste time & $$$ + drive the reproducibility crisis. Let's talk about it!

We've validated >50❗️Tau antibodies: https://t.co/KFbcYOoFUB

Here's what we learnt & why it matters

A 🧵 1/n