Dr. CA

Carbonic anhydrase enzyme lover. Ask me about them! (Biochem II Project)

[Dr. CA @DrCA_]

Introduction to Carbonic Anhydrases: A thread.

[Dr. CA @DrCA_]

@Bevhroy Winum, Jean-Yves, et al. "Design of Zinc Binding Functions for Carbonic Anhydrase Inhibitors." Current Pharmaceutical Design, vol. 14, no. 7, 2008, pp. 615-21. ProQuest, https://t.co/28WjvHQpvK, doi: https://t.co/ivGDTYvaWN.

[Dr. CA @DrCA_]

@Bevhroy Feel free to read more about it!!

Works Cited

Cheng, Xian-Chao, et al. "Role of Sulfonamide Group in Matrix Metalloproteinase Inhibitors." Current Medicinal Chemistry, vol. 15, no. 4, 2008, pp. 368-73. ProQuest, https://t.co/NUZhcIiRlL .

[Dr. CA @DrCA_]

@Raadhia3 Hope this answered your question!

Works Cited

Winum, Jean-Yves, et al. "Design of Zinc Binding Functions for Carbonic Anhydrase Inhibitors." Current Pharmaceutical Design, vol. 14, no. 7, 2008, pp. 615-21. ProQuest, https://t.co/28WjvHQpvK, doi: https://t.co/ivGDTYvaWN.

[Dr. CA @DrCA_]

@Raadhia3 This leads to reduced Zn-O distance, inhibiting the CA from working appropriately (Winum et al. 617). This specific type of CA enzyme is also found in the kidney, however, this might explain some of the renal side effects of the medication (Winum et al. 617).

[Dr. CA @DrCA_]

Huang, Shenghua, et al. “Organization of an Efficient Carbonic Anhydrase: Implications for the Mechanism Based on Structure-Function Studies of a T199P/C206S Mutant.” Biochemistry, vol. 41, no. 24, 23 May 2002, pp.
https://t.co/ZPtRhqkWZP

[Dr. CA @DrCA_]

Introduction to Carbonic Anhydrases: A thread.

[Dr. CA @DrCA_]

Frost, Susan C., and McKenna, Robert. Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications. Springer Netherlands, 2014, doi:10.1007/978-94-007-7359-2. https://t.co/Vem4EsWE7L

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