Andreu Casas Medina

MD - Hematology Resident, Hospital Germans Tries i Pujol. Ahora R4 🩸. No olvido que una vez fui med.Student.

[Andreu Casas Medina @Drew95C]

Recuerdo @amniebla que me hizo una clase de linfomas en Vall d'Hebron y me convenció de que esta era mi especialidad soñada.

Hoy soy R1 de Hematología en Hopital Germans Tries i Pujol 🩸 @HematoCanRuti #hematorulers #hematologia

[PmAmTraveller @pmamtraveller]

"Moirai" by artist Loles Romero

[Benlazar S M A @smbenlazar]

POLATUZUMAB-BR VS TAFASITAMAB-LENALIDOMIDE IN RELAPSED/REFRACTORY DLBCL https://t.co/Eq2jEBcqHW #EHA26 #lymsm

[Servicio de Hematología. Hosp. U. Morales Meseguer @crh_MoralesIMIB]

María del Mar Gracia, R-3 del Servicio nos dió la sesión “Dianas Moleculares e inhibidores de Menina en Leucemia Mieloblástica Aguda”. Los Residentes cumpliendo su responsabilidad de formación 👍👍👍

[Ankit kansagra @kansagraMD]

The reason bispecific responses fade in myeloma — T-cell exhaustion — may have a fixable epigenetic switch. New Blood paper (Chiu, Zhao et al, BMS) makes the mechanistic case for mezigdomide + TCE.

Preclinical but kinda neat. Ex vivo Tex model.

The exhaustion phenotype they reproduce is brutal:
• IL2 ↓, CCL17 ↓
• TOX/PD-1/TIM3/CD39 all climbing
• IKZF1 redistributes
• Tex kills BCMA-K562 with Alnuctamab far worse than Tact

What mezigdomide does in Tex:
• Degrades IKZF1/IKZF3 deeper than lena or pom in this system
• Reopens chromatin — Tact-like programming
• Cytokine genes (CCL17, CCL1/2, IFNγ) re-engage;
• >4-fold increase in target cell killing with Alnuctamab — EC50 back to Tact levels
• Same effect carries with teclistamab, talquetamab, and elranatamab

If you remember the how Iber works - Iberdomide degrades IKZF1 too (Tay, Cell Rep Med 2024), but iberdomide's registration program is + daratumumab. Mezig is going the TCE direction — phase 1 with elranatamab is enrolling (NCT06645678), and the companion clinical paper (Chen et al,) already shows PD-1 and TIGIT down on patient T cells in vivo after mezig.

Very intriguing indeed. If a short course of mezi can put exhausted T cells back into a functional state, "progression on bispecific" may not have to mean "switch agent."

Are headed toward CELMoD pulses to extend TCE durability, instead of cycling drug classes?

@BloodJournal @sparekh4 @szusmani @bmsnews @RahulBanerjeeMD @HiraSMian @bhemato

#Myeloma #mmsm #HemOnc

[Hellenist ☀️🏺⚡️ @RealHellenist]

Theatre of Ephesus: Before and After Excavations

[Benlazar S M A @smbenlazar]

The Immunologic Paradox of BTK Inhibitors in Chronic Lymphocytic Leukemia: Selectivity, Hypogammaglobulinemia, and Infection Risk https://t.co/v6SzaTIZni #mdpicancers via @Cancers_MDPI #cll #leusm

[Placentita del MIR @PlacentitaMIR]

Que será de la gente que hizo hidrología médica? A q se dedican ahora?

[Andreu Casas Medina @Drew95C]

@fercho_bilbao 🙄1.Trauma, 2.Derma, 3. Cx General

[Hematologia ICO Hospitalet @HematICO_Hosp]

Moltes felicitats @HematoCanRuti!!!
Benvinguts #MIR26!!! Residents #ICOnics

[FANfiqueiro padrão nuclear cansado 1:80 @morrovidigal]

você é das especialidades clinicas do bem (geriatria / reumato / endocrino) ou do mal (nefro / intensiva / hemato) ?

[Perseus @PerseusLeGrand]

C'est sans aucun doute l'une des églises les plus impressionnantes des États-Unis.

St. Patrick's Cathedral (New York City)

[Andreu Casas Medina @Drew95C]

¡Venga! que solo nos falta un resi 😝

[Dr RP Singh, MD @rpsingh1894]

🩸 CBC reading doesn’t have to be complicated.
Master the basics step by step:

🔴 Hb → Anemia?
⚪ WBC → Infection?
🔵 Platelets → Bleeding risk?

Learn to identify:
✔️ Iron deficiency anemia
✔️ Viral vs bacterial infection
✔️ Dengue clues
✔️ B12 deficiency
✔️ Pancytopenia patterns

A CBC can reveal life-saving clues within seconds if you know how to read it properly. 📋🩺

#CBC #CompleteBloodCount #Anemia #Medicine #MedTwitter #FOAMed #MedicalEducation #Hematology #Doctors #MedStudent #ClinicalMedicine #Pathology #MedicalLearning #Healthcare #BloodTest

[Andreu Casas Medina @Drew95C]

Aspirador de guardia. Era una promielocitica...

[Andreu Casas Medina @Drew95C]

En nada tendré mis últimos R pekes. Un año más sigo nervioso.

[▲TAURO▲ @tauro_hn]

Tauro vibes 🖤

[▲GÉMINIS▲ @geminis_hn]

Géminis vibes 🖤

[Ramin Nasibov @RaminNasibov]

Stephanie Rew

[▲GÉMINIS▲ @geminis_hn]

✨ ♊ ✨

[▲GÉMINIS▲ @geminis_hn]

Tu palabra es tu arma, Géminis, úsala para construir 🔥