Joshua Chan, DO, MS

Cardiology Research Fellow @UCIrvineHealth | IC · Preventive | CF-L2 Coach | Posts on cardiology, research & performance medicine

[National Lipid Association @nationallipid]

Lipid News📢: TRYNGOLZA® (olezarsen) approved by the FDA as the first and only treatment to reduce triglycerides and the risk of acute pancreatitis in patients with severe hypertriglyceridemia (sHTG).

Read the full announcement from @ionispharma: https://t.co/y7JktVGT8A

[Joshua Chan, DO, MS @DrJChan_DO]

HFpEF Explained — Prevalence, New Advances, and How to Diagnose | NEJM https://t.co/vpyfbwRYTn via @YouTube

The future for those with #HFpEF is bright 🌟

[Kevin S Shah, MD @KevinShahMD]

Over 20 years ago, I watched 45 minutes of resuscitation end in silence. The weeks before were filled with subtle symptoms, easy to dismiss. Until they weren’t.

That experience never left. It provided #lessons

• Not all risk announces itself
• Delayed recognition is common
• #Medicine has limits
• Sitting with patients in uncertainty is part of the work
• Community outreach can increase awareness and change outcomes

I wrote about this in a recent @JACCJournals HeartBeats piece:

“After the Code: The Space That Follows”

https://t.co/tomWdmZMt2

#cardiology #cardioX

[Updates in Medicine @medic_updates]

Sepsis care in 2026 isn’t about faster—it’s about smarter, individualized decisions that change outcomes.

[Dr sthanu subramanian @drsthanus]

A comprehensive chart of Hemodynamic Calculations, outlining various formulas used in clinical settings along with their corresponding normal average values.

https://t.co/mDT8b63wOI

[JACC Journals @JACCJournals]

New EAPC/ESC/ACC Statement updates abnormal CV findings in Masters athletes. Expert guidance on AF, bradyarrhythmias, ventricular arrhythmias, CAD, aortic dilatation, myocardial fibrosis, & exercise-induced arrhythmogenic cardiomyopathy https://t.co/yWBZAaupx6 #JACC #SportsCardio

[Joshua Chan, DO, MS @DrJChan_DO]

NEJM Clinician: Dementia Risk in Patients Achieving Low Diastolic Blood Pressure https://t.co/ukZ1QNaYCh

[CardiovascularCorner @TrackYourHeart]

MI Localization Made Easy: ECG + CMR Correlation

[CardiovascularCorner @TrackYourHeart]

Standard angiographic views are used to visualize different segments of the coronary circulation

[CardiovascularCorner @TrackYourHeart]

Mastering the ECG.

10 Simple Rules of a Normal ECG.

[CardiovascularCorner @TrackYourHeart]

AV Nodal Reentrant Tachycardia (AVNRT)
A common type of supraventricular tachycardia (SVT) seen in young adults and structurally normal hearts.

Basic Concept:
AVNRT happens because the AV node has two pathways that conduct electrical impulses differently:

1️⃣ Slow Pathway
-Conducts impulses slowly
-Recovers quickly (short refractory period)
2️⃣ Fast Pathway
- Conducts impulses quickly
- Recovers slowly (long refractory period)

Mechanism of How AVNRT Starts:
🔻Normally, impulses travel down the fast pathway to the ventricles.

🔻But if a premature atrial beat (PAC) occurs while the fast pathway is still refractory (not ready), the impulse gets blocked there.

🔻Instead, the impulse travels down the slow pathway.

🔻By the time the impulse reaches the bottom of the circuit, the fast pathway has recovered, allowing the impulse to travel back up retrogradely.

🔻This sets up a circular electrical loop (reentry circuit), creating AVNRT.

This results in:
✅ Forward conduction to the ventricles via the slow pathway
✅ Backward conduction to the atria via the fast pathway

ECG Features of AVNRT:
🔹Regular rhythm
🔹Narrow QRS complexes
🔹No visible P waves or pseudo R’ in V1 or pseudo S waves in inferior leads (due to near-simultaneous atrial and ventricular activation)
🔹Heart rate: usually 150–250 bpm

Clinical Significance:
🔸Presents as palpitations, lightheadedness, dizziness, or even syncope
🔹Often triggered by stress, caffeine, alcohol, or exercise
🔸Not usually life-threatening but can be very symptomatic
🔹Responds well to vagal maneuvers or adenosine
🔸In recurrent cases, radiofrequency ablation of the slow pathway offers a cure

#ECG

[American College of Cardiology @ACCinTouch]

📌 Filipino American adults have a higher prevalence of early onset #hypertension than any other Asian American subgroup and would benefit from earlier screening.

Explore the full expert analysis for more insights: https://t.co/irfkKou35C #cvPrev

[Joshua Chan, DO, MS @DrJChan_DO]

Thank you to the @ISHLT team for giving me the opportunity to present my poster on #Amyloidosis and #SIBO! This is the first of many #Cardiology conferences of my career and I’m beyond excited to continue my journey as a resident @UCIrvineHealth and future Cardiology fellow!

[The Heart @ZHeart11768530]

🔴So Many Antihypertensives: What to use? ❤️⤵️
1. Selecting IV antihypertensives in hypertensive emergencies

2. Selecting PO antihypertensives according to comorbidities (updated)

🔹By @MatthewHoMD
#Cardiology #FOAMed #MedEd #medstudent #paramedic #Cardiology

[Joshua Chan, DO, MS @DrJChan_DO]

Excited to present “Cardio-Gut Crosstalk” at #ISHLT2025: novel data linking cardiac amyloidosis biomarkers (↑TnT/NT-proBNP) to SIBO on breath testing. Could early SIBO detection improve quality of life in patients with #Amyloidosis ? 🚀

[Joshua Chan, DO, MS @DrJChan_DO]

An AI model on single-lead ECGs in ~250K people detected 3–7× higher heart failure hospitalization risk (C-index 0.72–0.83) and outperformed PCP-HF & PREVENT @JAMACardiology #AI #HeartFailure

[JAMA Cardiology @JAMACardio]

Most viewed in the last 7 days from @JAMACardio:

A noise-adapted #AI algorithm using single-lead ECGs effectively predicted heart failure risk, showing improved performance over traditional risk scores.

https://t.co/N5POlzD7TY

[Joshua Chan, DO, MS @DrJChan_DO]

Beyond excited to be attending my first #Cardiology conference at @ISHLT #ISHLT2025 ! Can’t wait to meet everyone and connect! First time in #Boston so please send some recommendations!