Matthew D. Lloyd

Chemical Biology, Racemases/epimerases, enzyme kinetics, lipids, cancer, drug discovery. Taekwon-Do 5th Dan. Views my own.

[Matthew D. Lloyd @DrMatthewLloyd]

@simonmaechling If you tell Chemistry jokes, there is no telling whether you will get a reaction.

[Matthew D. Lloyd @DrMatthewLloyd]

@simonmaechling If i recall correctly, it stands for potenz, the German word for power. I only found this out myself quite recently, while writing an editorial with @bharath_IGC.

And it is not a dumb question.

[Matthew D. Lloyd @DrMatthewLloyd]

@simonmaechling Paracelsus, the father of Pharmacology.

Absolutely right. Even water is toxic in excess.

[Matthew D. Lloyd @DrMatthewLloyd]

@NobelPrize The Cori cycle is fundamentally important for glucose metabolism as it allows recycling of lactate produced in the muscles to glucose in the liver. Gluconeogenesis occurs in the liver as extra enzymes are required in addition to those for glycolysis.

[Matthew D. Lloyd @DrMatthewLloyd]

@clur_roberts Congratulations to your daughter and everyone who helped her get there. This is just fantastic.

[Matthew D. Lloyd @DrMatthewLloyd]

@DocPriyamMD @PharmXOAB Aspirin is an irreversible inhibitor of cyclooxygenase 1, while ibuprofen and related drugs reversible inhibit both cyclooxygenase 1 and 2, to approximately equal extents. The GI side-effects are due to COX-1 inhibition.

[Matthew D. Lloyd @DrMatthewLloyd]

@DocPriyamMD @kiddiewise_ Paracetamol is oxidised by CYP2E1 to form the electrophilic NAPQI. This reacts with glutathione. The glutamate and glycine in glutathione are removed, and the cysteine residue is N-acetylated. This is why N-acetylcysteine is used to treat Paracetamol poisoning.

[Matthew D. Lloyd @DrMatthewLloyd]

@DocPriyamMD If taking paracetamol stick to the dose and frequency, and speak to a Pharmacist if you need medicines advice.

[Matthew D. Lloyd @DrMatthewLloyd]

@DocPriyamMD Take an antibiotic. These symptoms are probably caused by a virus, and antibiotics are ineffective treatments. lnappropriate antibiotic use fuels antimicrobial resistance (AMR). Only take antibiotics when prescribed, as directed and finish the course.

[Matthew D. Lloyd @DrMatthewLloyd]

@drterrysimpson Peer review has its faults but most reviewers are conscientious and do their job thoroughly. Some journals have moved to double-blind Peer review to minimise unconscious bias. I personally avoid looking at author details when single blind reviewing.

[Matthew D. Lloyd @DrMatthewLloyd]

@Irina_exh 19/20 for me. Didn't have a Walkman.

[Matthew D. Lloyd @DrMatthewLloyd]

@Jkatian @simonmaechling Ibuprofen is sold as a racemic mixture, so it should be 50% effective.

The change in chirality is mediated by conversion to the acyl-CoA. I wonder if it is this step that fails. Some Ibuprofen analogue are not converted to the acyl-CoA, notably flurbiprofen.

[Matthew D. Lloyd @DrMatthewLloyd]

@Lucy_Oc1 Congratulations. A great achievement!

[Matthew D. Lloyd @DrMatthewLloyd]

@Hania16836 Most of the vitamin C in a potato is found in the skin. Eating potato skins and onions stopped people getting scurvy in the Second World War when Britain was blockaded and fresh fruit was scarce.

[Matthew D. Lloyd @DrMatthewLloyd]

@AyanAbdullePHD Congratulations. That's a great achievement.

[Kamil R Kranc @kamilkranc]

We are recruiting talented postdoctoral scientists in RNA and hypoxia biology to my lab at The Institute of Cancer Research in London!
Informal enquiries are warmly welcome: [email protected] 🔥

https://t.co/4G8DyL5wby

https://t.co/M0Vlm9hEx8

[Matthew D. Lloyd @DrMatthewLloyd]

@Turi__King @cjrw Congratulations to everyone involved!

[Matthew D. Lloyd @DrMatthewLloyd]

I am very happy to share this new editorial with Dr Bharath Srinivasan.

[Bharath Srinivasan @bharath_IGC]

I am thrilled to share the second part of our editorial series on "Quantitation and Error Measurements in Dose–Response Curves," published in Journal of Medicinal Chemistry! A huge thank you to my co-author @DrMatthewLloyd for our ongoing collaboration on this series
@JMedChem

[Bharath Srinivasan @bharath_IGC]

I’m thrilled to share our editorial, "Dose–Response Curves & the Determination of IC50 and EC50 Values," published in J. Med. Chem.!
🔬 The editorial deals with all aspects of DRC

Thanks to my co-author @DrMatthewLloyd for helping put this together.

https://t.co/i4r9WNcW6c