Duramente Orfevre

[FinalGathering™ @FinalGathering]

【秘技】老顔を改善してしまうツボ‼️

#アンチエイジングのツボ

[Electra @Electrarythm]

There is a certain type of person everywhere now, especially online.

He consumes endless information every day: philosophy, psychology, productivity, spirituality, neuroscience, business, self-improvement, history.

He knows a little about everything and deeply experiences almost nothing.

His entire identity becomes built around understanding instead of living.

He watches videos about confidence instead of speaking confidently. Reads about discipline instead of becoming disciplined. Studies relationships instead of learning how to love. Consumes motivational content instead of taking action.

He feels intelligent because he is constantly mentally stimulated. But stimulation is not transformation.

Most of the time, knowledge becomes emotional protection. Reality is unpredictable. Reality humiliates. Reality exposes weakness. Books and ideas do not.

Inside information, he can continue imagining himself as intelligent, deep, insightful, different from ordinary people. So he remains trapped in preparation.

He constantly feels as if he is "becoming" someone, while his real life remains strangely untouched. He develops sophisticated language for problems he never confronts directly. He can explain human behavior beautifully while being unable to handle ordinary discomfort, rejection, uncertainty, loneliness, or risk.

He slowly turns life into observation instead of participation.

The internet rewards this personality heavily. He receives validation for sounding aware rather than becoming capable.

Eventually, he begins confusing self-analysis with growth and information with wisdom.

But beneath the intelligence usually exists the same thing: fear. Fear of failure. Fear of embarrassment. Fear of reality answering back.

Because action destroys fantasy. The moment he truly acts, he can no longer hide inside potential.

[Geoff Keighley @geoffkeighley]

😂

[Cody Christian @ReallyCody]

i won’t let you down. i promise. 🫶

[DiscussingFilm @DiscussingFilm]

‘RESIDENT EVIL - VERONICA’ has been announced.

Releasing in 2027.

[Resident Evil @RE_Games]

Survive the deranged terror. Resident Evil Veronica reanimates in 2027 on PlayStation 5, Xbox Series X|S, Steam, and Nintendo Switch 2.

#REVeronica #ResidentEvilVeronica

[FINAL FANTASY VII @finalfantasyvii]

Final Fantasy VII Revelation, the thrilling conclusion of the FFVII Remake Series, launches simultaneously on PlayStation 5, Nintendo Switch 2, Xbox Series X|S, Epic Games Store and Steam in Spring 2027.

[TEKKEN @TEKKEN]

The Strongest Creature on Earth
JOINS THE BATTLE!!💥

Yujiro Hanma joins the #TEKKEN8 roster as the 4th additional playable character in early 2027🔥

[Duramente Orfevre @DuramenteO]

@nhamaguc フロムソフトウェアの宮崎さんは以前、ユーザーにあたえる情報量について多すぎても、少なすぎてもいけないと言ってましたが、そ���はマーケティングについても同じことがいえると思います。REBIRTHの時のあなたのインタビュー量は明らかに過剰に感じました。3作目は気を付けてくれるとうれしいです。

[Geoff Keighley @geoffkeighley]

PlayStation has reported a 765 Million dollar impairment loss due to underperformance by Bungie.

[たまちゃん @tama12180]

いえ、やばくありません。700万円は思考停止で使って、底を尽きたら生活保護申請すると良いです。月5万円の年金はナマポ基準より低いので通ります。持ち家あっても受けられます、役所から貴方に手紙が届きますが「面倒見れません」と跳ね返せばOKです。これで医療負担もゼロ、むしろ美味しいです

[Dexerto @Dexerto]

A 55-year-old dad shared how Pragmata's character Diana helped remind him of his 8-year-old daughter who died in 2009

“I absolutely love this game and the time Ella spends with me. PRAGMATA is therapeutic for my soul”

[Duramente Orfevre @DuramenteO]

@3_quma 熊部さん、もしDMC6のディレクターをやっているのなら、楽しみにまってます。
2030年あたりかな・・

[𝕵𝖍𝖊𝖗𝖊𝖒𝖎 @Nekromoni]

@MrMoonKnightXD Es q freyaGOD 🛐🛐

[William A. Wallace, Ph.D. @WilliamWallace]

Vitamin B12 is absorbed through two pathways. The first is intrinsic factor, a protein produced by parietal cells in the stomach. IF binds B12 in the small intestine and carries it across the gut wall via a receptor called cubilin in the distal ileum. This pathway is efficient but has a hard ceiling: it saturates at roughly 1.5 µg per dose. No matter how much B12 you swallow beyond that, IF cannot carry any more.

The second pathway is passive diffusion. About 1 to 2% of any oral dose diffuses across the intestinal lining without IF, and this occurs along the entire length of the gut. At dietary doses, this pathway is negligible. At supplement doses, it becomes the primary route of absorption.
Adams et al. (1971, Scand J Gastroenterol) measured whole body retention of radiolabeled cyanocobalamin at different doses. At 1 µg, roughly 50% was retained. At 5 µg, about 20%. At 25 µg, just over 5%. The NIH Office of Dietary Supplements reports approximately 2% absorption at 500 µg and 1.3% at 1,000 µg.

The fraction drops dramatically. But the total amount absorbed keeps rising. At 1 µg you absorb about 0.5 µg. At 1,000 µg you absorb roughly 13 µg total, of which approximately 10 µg comes from passive diffusion alone. The RDA is 2.4 µg. Even the backup pathway, working at 1% efficiency, delivers more than four times your daily requirement from a single pill.

This is the basis for high-dose oral B12 as an alternative to injections in patients who lack intrinsic factor. The NIH notes that high-dose oral supplementation "may be another treatment option" for pernicious anemia, though injections remain standard first-line therapy and the available randomized controlled trials comparing the two approaches are considered limited in quality.
One important nuance: absorbing B12 into your bloodstream is only the first step. After absorption, B12 must bind to a transport protein called transcobalamin to reach your cells. This complex, holotranscobalamin, is the biologically active fraction. It represents only about 20 to 30% of the total B12 circulating in your blood. The remaining 70 to 80% rides on a separate protein called haptocorrin, which does not deliver B12 to most tissues.

This is why serum B12 can be misleading as a status marker. A person can have a "normal" total serum B12 level while their holotranscobalamin, the fraction that actually delivers B12 to cells, is low. Methylmalonic acid is a more sensitive functional marker because it rises when cellular B12 is genuinely insufficient, regardless of what total serum B12 shows.

Absorption determines how much B12 enters your blood. Transport determines how much reaches your cells. Testing only total serum B12 measures neither of these processes accurately.

Adams et al., Scand J Gastroenterol, 1971
NIH Office of Dietary Supplements, 2024
Allen et al., J Nutr, 2018

[William A. Wallace, Ph.D. @WilliamWallace]

Most people who take vitamin C take 1,000mg in a single pill. Most people who criticize that dose say absorption drops above 200mg so you're wasting your money. Both groups are missing the more interesting part of the data.

Levine et al. (1996, PNAS) conducted one of the most rigorous vitamin C pharmacokinetic studies ever done. Seven healthy men were hospitalized for 4 to 6 months on a diet containing less than 5mg of vitamin C per day. They were then repleted at seven sequential doses from 30 to 2,500mg, with steady-state plasma concentrations measured at each level.

The absorption curve is sigmoidal. Bioavailability is complete (100%) for a single 200mg dose. At 500mg it drops to roughly 73%. At 1,000mg it drops to roughly 50%. At 1,250mg it is approximately 33%. The intestinal transporter SVCT1 saturates, renal excretion increases, and the fraction you absorb declines with every step above 200mg. Levine et al. (2001, PNAS) confirmed the same pattern in 15 women.
This is the part most people stop at. It's also where the analysis gets lazy.

The fraction drops, but the total milligrams absorbed still increases. At 200mg you absorb about 200mg. At 500mg you absorb about 365mg. At 1,000mg you absorb about 500mg. You are absorbing more vitamin C at every dose increase. You are just doing it less efficiently per milligram. Less efficient is not the same as useless.
This matters because of what happens on the demand side. Immune cells, particularly neutrophils, monocytes, and lymphocytes, actively concentrate vitamin C to levels 50 to 100 times higher than plasma through SVCT2 transporters. In healthy people consuming at least 100mg per day, intracellular concentrations reach roughly 1.5 mM in neutrophils and 3.5 mM in lymphocytes. These cells saturate at about 100mg daily intake under normal conditions.

But conditions are not always normal. During infection, inflammation, surgery, or critical illness, plasma vitamin C can drop below 30 micromol/L within days. Activated neutrophils burn through vitamin C during the oxidative burst, taking up oxidized dehydroascorbic acid via glucose transporters and reaching intracellular concentrations as high as 10 mM. The body pool, roughly 1.5 to 2 grams total, can be substantially depleted during severe illness. At that point, the rate of consumption exceeds what a 200mg dose can replace.

This is the argument for higher doses during illness. Not that absorption is efficient. It is not. But that the absolute amount reaching your bloodstream is still higher at 500 or 1,000mg than at 200, and during periods of high demand, that additional supply maintains the plasma floor your immune cells draw from. The Cochrane review on vitamin C and the common cold (Hemila & Chalker, 2013) found that regular supplementation (200mg to 2g daily) reduced cold duration by 8% in adults and 14% in children, with larger effects in those under physical stress.

The practical insight is not about whether to take more. It is about how to take it.

200mg taken five times per day delivers approximately 1,000mg absorbed, because each individual dose falls within the range of complete bioavailability. 1,000mg taken once per day delivers approximately 500mg absorbed, because the single large dose exceeds SVCT1 saturation.

Same total dose. Roughly double the absorption. If you are going to take a gram of vitamin C per day, splitting it into smaller doses across the day is a straightforward way to get more of it into your body.
For most healthy people eating a reasonable diet, 200 to 400mg per day is sufficient to saturate plasma and immune cells. Supplementation beyond that has diminishing returns under normal conditions. But during acute illness or high physical stress, the math changes because the demand side changes, and split dosing becomes the most efficient way to meet it.

Levine et al., PNAS, 1996
Levine et al., PNAS, 2001
Hemila & Chalker, Cochrane Database Syst Rev, 2013

[TRUTH TELLER @truth_teller58]

Got what you deserved 😂

[Cleytus @CleytusLive]

@geoffkeighley

[syounan.tansuke @STansuke]

論文にはなんだかんだ書かれているが、結局これ😂

「他人のアラを探しているうちは、自分の姿を見なくて済む」
　三島由紀夫

他人の欠点や過ち、不完全な部分に焦点を当て、それを攻撃したり批判したりしていれば、自分自身の内面の醜さ、不完全さ、あるいは自分自身が直面するべき問題から目をそむけ、それらと対峙することから逃避できる。

SNSなどで、特定の人や集団の過ちを執拗に探し、攻撃する人々は、この言葉が示す心理と重なる。
彼らは、自身の生活や内面の問題から目をそらすために、他人の粗探しに日夜没頭し、自己を保ち自分の弱さから逃げ続けるのである。

[ヤマクマ @yamakuma_shisan]

【警告】親が元気なうちに絶対に見てください。亡くなった直後、悲しむ暇もなく「14日以内の手続きラッシュ」が始まります。手順を間違うと即座に口座凍結。葬儀代すら引き出せず、精神的に追い込まれる人が後を絶ちません。知識ゼロでもパニックにならない「時系列ロードマップ」を完全網羅しました↓