Vanja Čekić

[Karen Pinto DNB, FRCPath @TheKarenPinto]

60 year old female
case of breast cancer on follow up
presented with a 2cm neck swelling.

#pathology #lymphnode #Hemepath #pathtweetorial

[Joe @MBBS_Pathology]

A nice example of the abrupt transition between the normal and the neoplastic.
#CGIN
#pathology
💙

[Tim Bracey @drtimbracey]

Staging scan for sigmoid adenocarcinoma picks up this inguinal nodal mass which was biopsied, what is your diagnosis and what IHC would you perform if any? https://t.co/vFtioedigU

[Janira Navarro @Janiranavarro]

Crowded endometrial glands that fall short of EIN criteria are often reported as “atypical glandular crowding” or “glandular crowding.”
What’s the clinical significance?

A large retrospective study (79,998 specimens) identified 167 such cases. Within 1 year, 28% were diagnosed with EIN, most within the first 4 months.

Roughly 1 in 4 patients will be found to have EIN or carcinoma on follow-up.

Pic, Left side: minute ( < 1 mm) detached fragment of crowded, atypical endometrial glands—a focus too small to meet the diagnostic size threshold for EIN
Pic, right side: Follow-up endometrial curettage from the same patient (20×) demonstrating a FIGO grade 1 endometrioid adenocarcinoma

Dr. Zeidel et al. Glandular Crowding of the Endometrium: Clinical Outcomes of a Diagnostic Gray Zone
DOI: 0.1097/PGP.0000000000001165
#Gynpath #pathology #PathX #PathTwitter

[Lorand Kis @kis_lorand]

👇this case showed homogeneous p16 positivity in tubal metaplasia 😱PITFALL ALERT!!!
https://t.co/AnGiNnYO3v

[Janira Navarro @Janiranavarro]

Variability in diagnosis of invasive lobular carcinoma (ILC)
Sources of discordance:

• E-cadherin-positive ILCs harboring CDH1 missense mutations (Pic 2; this case showed retained β-catenin staining and interestingly, E-cadherin-negative LCIS)
• E-cadherin-negative ILCs with tubular elements (Pic 3)
• ILCs with trabecular pattern (Pic 4; most experts in this study classified it as non-lobular breast carcinoma based only on H&E morphology). Check this interesting study: DOI: 10.1002/cjp2.253

Dr. Calhoun #BreastPath #PathX #PathTwitter #USCAP

[Pei Hui @Hui2Pei]

Discussion of Y-GTD Case of June 2026 is presented here: https://t.co/rqjlHbNveu @yalepathology
https://t.co/JzYGZR0f1e

[Janira Navarro @Janiranavarro]

Histology of Breast at Various Ages

Dr. Hoda. Histology Bootcamp-Breast #USCAP25 #PathX #pathology

[Guan-Nan Zhang ，张冠楠，MD, PhD @GuannanTiffany]

🧩 Bladder riddle

A nested lesion in the bladder. 🤔

Does every nested proliferation in the bladder have to be urothelial carcinoma?

What is your diagnosis?

#DxMindMap #BladderPath #GUPath #PathTwitter #Mimicker @JHUpath

[Janira Navarro @Janiranavarro]

Breast - Infiltrating epitheliosis
Key histologic features (Eusebi & Millis)

• Predominantly florid usual ductal hyperplasia (UDH) with focal squamoid areas
• Scleroelastotic stroma distributed throughout the lesion (not limited to a central nidus like radial scar (RS)/CSL)
• Frequent desmoplastic reaction + keloid-like fibrous bands

Unlike classic UDH, ducts show jagged/irregular edges with epithelium “flowing out” into stroma → more infiltrative appearance
IE is possibly related to radial scar/complex sclerosing lesion family. Lacks clear zonal architecture; myoepithelial cells are frequently discontinuous or absent

Dr. Lerwill #USCAP2026 #pathology #PathX #PathTwitter

[Lester Thompson @HeadandNeckPath]

Expanding the Histologic Spectrum of HPV-Associated Oropharyngeal Carcinoma: A Study of 379 Cases Focusing on Classification, Histologic Features, &amp; their Prognostic Significance
https://t.co/53B8fWkS2c
#HeadNeckPathol #HNPJ #HeadandNeckPath #Pathology #ENTPath #PathologyTweet

[Charlie Herndon @DrCycloPath]

Based on the excellent Head &amp; Neck Histology Boot Camp by @nicolecipriani at USCAP 2026:

https://t.co/pGHIok93lh

[Charlie Herndon @DrCycloPath]

Laryngeal anatomy matters because stage depends on tumor location.

False cord = supraglottic compartment
True cord = glottic compartment

[Sandra Sanchez, M.D. @SandraIxchelS]

Post treatment: rare case of residual carcinoma only within lymphovascular spaces.

Not accounted for in the AJCC TNM staging system. Some have advocated for the use of ypTX or ypT-LVI

See CD31 IHC!

[Vanja Čekić @EkiVanja]

@JMGardnerMD @GeisingerPath Congratulations, Dr Jerad! ✨

[Janira Navarro @Janiranavarro]

Ectopic pregnancy with fetal parts and yolk sac remnant (or simply yolk sac), Pic 1

It is not common to see a yolk sac in a POC specimen or even in ectopic pregnancy. It looks concerning, but once you see one, you'll recognize it faster next time.

Yolk sac, high power (Pic 2)

For the best educational thread on yolk sac, check @leon_metlay's post: https://t.co/wNu2SXpYqe

Another yolk sac post from Dr. Kaur's ISGYP presentation: https://t.co/x8H67pzXBZ

#everydayGYN #PathX #pathtwitter

[Nilüfer Kadıoğlu @nilufer510]

Thanks for your efforts on making this archive🙏@yro854⁩ and ⁦@Histopatolomon⁩ https://t.co/aMFdJuIJeC

[Kalyani Bambal @kriyer68]

#pathclassics

[Lorand Kis @kis_lorand]

Breast biopsy with the following histology. Classical 3 questions 😀
1. What is the phenotype of the cells?
2. What is your understanding about the GATA3 expression of the cells?
3. If you see the same lesion in cervical biopsy what would you call it?
#pathology #breastpath

[Felipe D'Almeida @FelipePatologia]

A classic monophasic spindle cell Synovial Sarcoma and its next generation immunohistochemical marker, the antibody SSX::SS18, which identifies the fusion protein of this fusion driven sarcoma.

Baranov E, et al. PMID: 32141887