Why anticoagulation in DVT, PE and Antiplatelets in myocardial infarction!!
Red thrombus vs White thrombus!
1. DVT (Deep Vein Thrombosis)
》Pathophysiology: DVT occurs in the venous system, where stasis of blood, hypercoagulability, and endothelial injury (Virchow's triad) lead to clot formation.
》Clot Composition: Venous thrombi are fibrin-rich and contain lots of red blood cells and fewer platelets. These are sometimes called "red clots."
》Treatment Rationale: Since the clot is largely fibrin-based, anticoagulants like heparin, warfarin, or DOACs (e.g., apixaban, rivaroxaban) are effective—they target the coagulation cascade and prevent fibrin formation.
2. Myocardial Infarction (MI)
》Pathophysiology: MI is often due to rupture of an atherosclerotic plaque in a coronary artery, which triggers platelet activation and aggregation.
》Clot Composition: Arterial thrombi are platelet-rich, also called "white clots," formed under high shear stress.
》Treatment Rationale: Antiplatelet agents like aspirin (inhibits COX-1, reducing thromboxane A2) and P2Y12 inhibitors (e.g., clopidogrel, ticagrelor) are key to prevent platelet aggregation and subsequent occlusion of the coronary artery.
What are the top 5 cardiology studies of 2023-24?
This is an invitation to participate in a brief survey to identify the "top 5" cardiology studies of 2023-24 most relevant to #pharmacists who practice in general or primary care settings. @CPJ_RPC https://t.co/AdfaVwK2Ia
❣️Enhance your knowledge. Elevate patient care.❣️
On Feb. 1, join CSHP and @CCPNrx at the Canadian Pharmacy Atherosclerotic Cardiovascular Disease Symposium and equip yourself with strategies to best manage patients with ASCVD.
Learn more and register➡️ https://t.co/YM4QIqqp3z
BREAKING NEWS
The 2023 #NobelPrize in Physiology or Medicine has been awarded to Katalin Karikó and Drew Weissman for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19.
📢Call for abstracts 📢
If you have created a research poster, and not yet shared it, this is your opportunity to share with your CSHP-AB colleagues at CABS!
Submission instructions: https://t.co/MNadWF1x9n
The new ELSO guidelines, describing #ECMO circuits for all
patient populations, adult and pediatric, are now available, open access on @asaiojournal These consensus guidelines describe safe practice based on extensive experience.
Download full text #FOAMcc
https://t.co/Miu9sbY2gs
CSHP Alberta Branch is launching a Mentorship program and new website in Spring 2022!
Interested in being a mentor? Sign up here: https://t.co/YDXxyhukzr
Interested in finding a mentor? Stay tuned, and see the March newsletter for more details!
#research#mentorship
It’s official! We are the first accredited Advanced Pharmacy Residency Program in Cardiology in Canada! We are accepting applications until Jan 31, 2022. @CSHP_SCPH@UAlberta_DoM@UAlberta_Pharm@AHS_media
Finally, a therapy that improves outcomes in #HFpEF!
Awaiting full results at #ESCCongress#ESC21, but a press release announced meeting the trial endpoint of significant ↓ in CV death or hospitalization for HF w/ empagliflozin. Big win for patients!
https://t.co/2nvKMBTYeT
Pharmacist‐led medication optimization increased the use of guideline-directed medical therapy in ambulatory patients with HF, and may be associated with fewer hospitalizations and deaths. https://t.co/wDHiIP8ls7 @accpcardprn@accpambuprn
My favourite projects involve research questions that stem from real clinical scenarios. Happy to see this work published!! @HeartLungCirc @emetchnikoff
https://t.co/wyApaHdZot
Couldn't have asked for a better group to work with (@Ricky_Turgeon, @iheart_Rx, Vivien Cao) and to highlight the benefits of an advanced pharmacist scope of practice in HF!
Pharmacist‐led medication optimization increased the use of guideline-directed medical therapy in ambulatory patients with HF, and may be associated with fewer hospitalizations and deaths. https://t.co/THoLYJvw1W @accpcardprn@accpambuprn