July is Sarcoma and Bone Cancer Awareness Month, inspiring our case of the month:
A 30yoM presents with a tumor arising on the surface of the posterior femur. MDM2 amplification is detected by FISH.
What's your diagnosis? (see poll below)
#BSTpath
https://t.co/g4quwLsshE:
Angiomyolipomas (PEComa family) can affect the kidney, but are more likely to arise in the kidney and involve the adrenal gland secondarily. Classic angiomyolipomas are triphasic tumors consisting of perivascular epithelioid cells clustered around irregular thick-walled blood vessels in a background of mature adipose tissue.
#EndoPath #BSTPath
More on infectious disease pathology (https://t.co/FcZSxlmu8o):
Disseminated disease occurs in 25-40% of patients with pulmonary blastomycosis (buzz words: "broad-based budding"), with the most frequent sites being skin, bone, GU tract, and CNS. H&E, GMS, and PAS shown.
#IDpath
From the infectious disease fascicle (https://t.co/FcZSxllWiQ):
Giardia duodenalis is one of the most common intestinal parasites. On biopsy, small bowel mucosa may appear entirely normal with trophozoites in the intervillous spaces in a “falling leaves” pattern.
#IDpath
One of my favorite 40x fields I've ever seen! Beautiful ladybird cells (neoplastic cells with a cytoplasmic rim of hemosiderin) in a tenosyonvial giant cell tumor. #BSTpath
More from the non-helminth infectious diseases fascicle (https://t.co/FcZSxllWiQ):
Leprosy, caused by Mycobacterium leprae/Mycobacterium lepromatosis, has diverse histologic findings; tuberculoid leprosy has perineural lymphocyte and epithelioid histiocyte infiltrates.
#IDpath
More from the infectious disease fascicle (https://t.co/FcZSxllWiQ):
Rabies virus is a neurotropic, enveloped, nonsegmented, single-stranded RNA virus, and is uniformly fatal in humans once clinical symptoms start. In infected brain tissue, Negri bodies can be seen.
#IDpath
⭐ MACROSCOPIC PATHOLOGY⭐ If you haven't read our March 2024 issue on Macroscopic Pathology https://t.co/gMEt7GAOde, here's another opportunity. Two-day seminar organized by Dr. Murali Varma. And it's free! Register now! @MuraliV72899596
This classic example of ossifying fibromyxoid tumor displays a shell of bone and uniform cytologic features; it's an H&E diagnosis. Without classic features, detecting PFH1 rearrangements (several partner genes reported) is useful. #UMiamiPath PMIDs: PMID: 2476942, 23887158.