On the cover of this week's issue: "Enzyme Enhancement Through Computational Stability Design Targeting NMR-Determined Catalytic Hotspots"
Read it here 🔗 https://t.co/6X2tVv0K2j
"High-efficiency Kemp eliminases by complete computational design" - de novo designed and computationally optimized enzymes with up to kcat/KM of 12500 M-1, increase to >10^5 M-1s-1 by additional mutation of an aromatic residue. Out on @biorxiv 1/
https://t.co/ZtHwszUBTF
Are you excited about finding out how new proteins emerge and evolve? So are we! Come join us in beautiful Lund! 2 year computational postdoc, in collaboration with Marie Skepö. Submit your application by December 31st for full consideration.
https://t.co/u9GkCZrj8n
BREAKING NEWS
The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”
Our combined structural, kinetic, NMR and computational paper probing conformational control of loop dynamics in a key enzyme of histidine biosynthesis, HisF, is now online at @JACS_Au ! Collaboration with Reinhard Sterner, Remco Sprangers, and others. https://t.co/FDXruZplTb
Want to join us? Application for a 4 year PhD #FPI contract at the Chemistry Department of @UAM_Madrid is now open to work on the simulation of the mechanism of action of DNA targeting drugs. DM for more info.