Brandon Moore, PhD

Head of AI Research & ML Engineering @ 1910

[Brandon Moore, PhD @fatal3rror]

I've migrated over to Blue Sky where I continue my daily science and engineering posts. See you all there folks! 🦋

https://t.co/oPlYg60Z9d

[1910 @1910_ai]

We're excited to announce the publication of PEGASUS™—our breakthrough AI model that solves one of the toughest challenges in drug discovery: designing macrocyclic peptides with oral bioavailability.

Featured Article in the Journal of Medicinal Chemistry. 🧵

[Jen Asher, Ph.D. @jenasherphd]

Today, @1910_ai is thrilled to announce the publication of PEGASUS™, a state-of-the-art AI model for de novo design and optimization of macrocyclic peptides.

▪️Paper: https://t.co/cIJ0pacEZR
▪️Press Release: https://t.co/3nl91kUzGa
▪️ BD: To partner on PEGASUS™, [email protected]

[Brandon Moore, PhD @fatal3rror]

Exciting News! @1910_ai PEGASUS™ paper is now published in J Med Chem! This AI model can design macrocyclic peptides that maintain cell permeability, a major challenge for this emerging drug class!

Paper:
https://t.co/DGpsV5th9l

Press Release:
https://t.co/FTE01cNkmL
.

[Brandon Moore, PhD @fatal3rror]

Exciting News! @1910_ai CANDID-CNS™ paper is now published in JCIM! This AI model helps predict which drugs can cross the blood-brain barrier, a major challenge in drug discovery!

Paper:
https://t.co/1smU8Gp2iE

Press Release:
https://t.co/5mpqtyyc7y

[1910 @1910_ai]

Today, 1910 is thrilled to announce the publication of CANDID-CNS™, a state-of-the-art AI model that predicts BBB penetration by unlocking Beyond-Rule-of-5 (bRo5) chemical space and stereochemistry of small molecules.

[1910 @1910_ai]

We are collaborating with @Microsoft to accelerate #drugdiscovery. Using Azure Quantum Elements to supercharge our integrated #AI, computation, and biological automation platform, 1910 can design drug-like molecules better than traditional approaches. https://t.co/UBEY0fsTNM
#hpc

[Brandon Moore, PhD @fatal3rror]

My tenure at @1910Genetics has allowed me to make significant contributions on our journey to becoming a leading drug discovery company. Now I'm taking our work to the next level as the Head of AI Research and ML Engineering. Lets make undruggable targets a thing of the past!

[1910 @1910_ai]

Three years ago, Brandon Moore became the first employee at @1910Genetics and joined us to realize the vision of making undruggable targets a thing of the past. Today, we announce that he has been promoted to the Head of AI Research and Machine Learning Engineering.

[Brandon Moore, PhD @fatal3rror]

The Office of Science and Technology Policy @WHOSTP45 just released a memo stating taxpayer-supported research must be made available to the American public at no cost. Agencies must implement this policy by 2026!

This is a huge win for open science!

https://t.co/5RYBrHQOyD

[Brandon Moore, PhD @fatal3rror]

Ancient birds gained a taste for sugar via a change in their umami receptors. Eurasian wrynecks (Jynx torquilla) have since reverted back via a small mutation likely resulting in the preference for eating ants over a more omnivorous woodpecker diet.

https://t.co/olDJFaw6sL

[Brandon Moore, PhD @fatal3rror]

PFAS are a problem because they bio-accumulate and don't naturally break down. The @Dichtel lab just discovered how to degrade these organo-fluorines using simple reagents (lye and DMSO)! This process literally takes the F out of "forever chemicals"!

https://t.co/Xay9tSKuEc

[Brandon Moore, PhD @fatal3rror]

Otodus megalodon is one of the largest predators to have ever lived. Recent 3D modeling efforts suggest these massive beasts likely swam faster than any living shark and dined on prey that were the size of killer whales (Orcinus orca)!

https://t.co/qZuSnHbr9i

[Brandon Moore, PhD @fatal3rror]

A recent study conducted aboard the International @Space_Station demonstrates how vibrations occurring perpendicular to water droplets in low gravity will cause the liquid to oscillate rhythmically!

https://t.co/8ZVSRj6zQo

[Brandon Moore, PhD @fatal3rror]

Paruroctonus soda (Female specimen in photo) and Paruroctonus conclusus are newly identified playa scorpion species discovered by two Bay Area high school students using @inaturalist while adventuring in the Mojave Desert!

https://t.co/S6XZUsAne1

[Brandon Moore, PhD @fatal3rror]

Bonobos (Pan paniscus) pout to gain sympathy during conflict resolution! This adds to the evidence suggesting non-human apes have some level of voluntary control over emotional expression!

https://t.co/JLOdsmZWPA

[Brandon Moore, PhD @fatal3rror]

@jmhredsox Totally! I never knew how those worked! Neat!

[Brandon Moore, PhD @fatal3rror]

Jumping rhythmically on a flat floating surface like a paddle board or canoe can propel it forward via a process called Gunwale bobbing which allows the watercraft to "surf" along its own generated wake!

https://t.co/QREGl1OdcZ

https://t.co/siJ0a1AHOb

[Brandon Moore, PhD @fatal3rror]

The @DunningHotopp lab recently discovered that fruit fly (Drosophila ananassae) genetic material contains the entire genome of a completely separate bacterial species (Wolbachia)!

https://t.co/bJV0qSf2vu

[Brandon Moore, PhD @fatal3rror]

@GIST_science researchers recently built an amphibious panoramic camera inspired by fiddler crab (Uca arcuata) vision. These crustaceans have eyes which allows them to view their surroundings just as capably on land as they can under the sea. 🦀

https://t.co/MOPiuNW6li

[Brandon Moore, PhD @fatal3rror]

Recently discovered imprints of single celled plankton were found embedded in fossilized organic matter. These "ghost fossils" suggest that coccolithophores were more resilient to global warming effects than previously hypothesized!

https://t.co/GPiyTctgFi