Michael Fessler, MD

Senior Investigator @NIEHS Intramural. Physician scientist. Heads #innateimmunity #Fesslerlab in RTP, NC. #Macrophage #Immunometabolism Opinions are my own.

[Michael Fessler, MD @FesslerMd]

@GowdyKymberly @NIEHS @OSUWexMed @OhioStateDHLRI @OSUPCCM_Fellows Wow! Congrats!!

[Michael Fessler, MD @FesslerMd]

@JCI_insight Outstanding work by talented PD fellow Sookjin Moon that finds that raft protein Flot2 is a brake on TCR signaling and T cell function.

[Michael Fessler, MD @FesslerMd]

@jmvyasmdphd @ColumbiaMed @Columbia Wow, Jay! Congratulations!

[Michael Fessler, MD @FesslerMd]

@TeminiAjayiMD @ForegutSociety @milenasuarez @WasseemSkefMD @ReenaChokshiMD @iGUT_Houston Well done, Temi! Congrats!

[ATS Red Journal @AJRCMB]

📣 CALL FOR PAPERS-Climate Change

Showcasing papers that investigate the mechanisms by which environmental climate change-related factors impact lung health and disease

Deadline is October 1, 2024

More information here:
https://t.co/EPGUe2AguM?

[Journal of Clinical Investigation @jclinicalinvest]

#ResearchLetter:
Sterol biosynthesis regulates TLR signaling and the innate immune response in a Smith-Lemli-Opitz syndrome model: https://t.co/KwQynWiwvO

@FesslerMd @NIEHS
#Immunology #Inflammation

[ATS Red Journal @AJRCMB]

📣 CALL FOR PAPERS-From Multi-Omics to Mechanisms of Lung Disease 📣

Focusing on the use and impact of multiple omics technologies associated with respiratory diseases, lung development, and precision medicine strategies.

Deadline is March 1, 2024
https://t.co/W2US6EgfPu

[ATS Red Journal @AJRCMB]

Meta-Analysis of COVID-19 BAL Single-Cell RNA Sequencing Reveals Alveolar Epithelial Transitions and Unique Alveolar Epithelial Cell Fates

🔓 Open Access
🔗 https://t.co/3z6HuQ06yx

[ATS Red Journal @AJRCMB]

Endogenous and Therapeutic 25-Hydroxycholesterols May Worsen Early SARS-CoV-2 Pathogenesis in Mice

🔓 Open Access
🔗 https://t.co/krcDZhnUnO

[Ivan Zanoni @Lo_Zanzi]

#WeekendRead! #InterferonPower ! Fessler &co show ⁦@jclinicalinvest⁩ that IRGM1 prevents excessive type I #IFN production & macrophages lytic death/necroptosis, allowing the differentiation of mature macrophages during bacterial infections! https://t.co/c9jKoGA7r3

[ATS Red Journal @AJRCMB]

Meta-Analysis of COVID-19 BAL Single-Cell RNA Sequencing Reveals Alveolar Epithelial Transitions and Unique Alveolar Epithelial Cell Fates

🔓 Open Access
🔗 https://t.co/3z6HuQ06yx

[Michael Fessler, MD @FesslerMd]

@li_liwu @Tatalab_Duke @TataAleksandra Thank you, Liwu!

[Michael Fessler, MD @FesslerMd]

Our latest paper, led by talented Peer Karmaus with help from @Tatalab_Duke @TataAleksandra and other collaborators: https://t.co/3mZkqkR64U

[Michael Fessler, MD @FesslerMd]

@hskulkarni @AJRCMB Thanks, Hrish!

[Michael Fessler, MD @FesslerMd]

IF staining of patient lungs confirmed the AT1 cell state. Interesting implications for unexpected repair pathways in lung and perhaps for diagnosis and therapy. @AJRCMB

[Michael Fessler, MD @FesslerMd]

Peer harmonized public #COVID19 vs control BAL #scRNAseq datasets to detect rare cell states in the infected #lung. Among his many findings was evidence for aberrant alveolar epithelial type 1 cells with cornification and other signatures reminiscent of the skin!

[Michael Fessler, MD @FesslerMd]

@PeterChenMD Thanks so much for the invite, Peter. Had a great time visiting your outstanding Division.

[@tatalab-duke.bsky.social @Tatalab_Duke]

1/7 Latest paper in @CellStemCell! Transitional cell states sculpt tissue topology during lung regeneration. This work was jointly led by @arvikonk @KonishiSatoshi @TataAleksandra & Lauren with help from colleagues in our lab and collaborators @Duke https://t.co/CkxOqspF6u

[Jeff Rathmell @JeffRathmell]

Check out the line-up for the Gordon Research Conference on Immunometabolism! Excited to co-lead this with @LynnHedrickAU @PCHo_Lab & Nancie MacIver.
Mark your calendars--Registration is open!
https://t.co/BsSVD5TERn

[Michael Fessler, MD @FesslerMd]

This counters the longstanding paradigm of IRGM1 as an #interferongamma cell-autonomous antimicrobial protein. Exciting implications. Thanks to our collaborators @mayer_barber and Greg Taylor.

[Michael Fessler, MD @FesslerMd]

Pleased to announce the latest work of talented Prashant Rai @mitoimunfection just published in @jclinicalinvest : https://t.co/fuGficKrk9. We show that IRGM1 supports #hostdefense against intracellular #bacteria by suppression of type I #interferons!