Dr.Freebase

Aspiring to everything, accomplishing nothing.

[Dr.Freebase @Fifty_Precent]

Plugging that one comic I did because my virtual onahole has forsaken me
https://t.co/XEtLTdW6oz

[Think Before You Sleep @TBYSTweet]

This guy has changed my whole life as an adult.

[Dr.Freebase @Fifty_Precent]

@Armed1488 Jewgrounds

[Dr.Freebase @Fifty_Precent]

Skaaa

[Dr.Freebase @Fifty_Precent]

50 on da ring camera

[a @a8065287968522]

Im i am infertile from eating scented candles. The

[Dr.Freebase @Fifty_Precent]

@EPSTEIN_ALIVE Wuts ur comic

[Dr.Freebase @Fifty_Precent]

I'm going to kill myself

[Geogristle @geogristle]

me and the gf (to scale)

[nic carter @nic_carter]

The unbearable weight of the knowledge that I will never see the color Olo

[Tristin Hopper @TristinHopper]

Me too. I wrote it because I only have one passport and desperately need you all to stop demolishing the country where I'm trying to raise my children.

[Moongazer @joeybeastmarket]

>see picture of absolute goyslop
>a man in a dress who cannot overcome his biological urge to work in a coal mine
>it’s obviously fake
>google it
>it’s real
>it’s literally called queen of coal
>funniest shit ive ever seen

[George Alexopoulos @GPrime85]

Trans Miner: "I've always wanted to mine coal... as much as I've wanted to be a woman."
Men: "Jesus says you aren't allowed! Git outta here!"
Men 2: "We hate you! Grr!"
> Later that day, the mine collapses
Fat Capitalist CEO: "Dammit! All our miners are trapped down there, and there are no men left to save them!"
> Trans miner appears. "How about a woman?"
> BWAAAAAH sound
> CUT TO inside the mine, men are on their last breath.
> A hand comes down through the dirt.
> Carries every man out on her shoulders.
> Everyine is outside, crying.
> Trans miner slings her pickaxe on her shoulder and walks quietly away.
Voice: "Wait!"
White Bigot: "Thank you, trans miner. You're different than us, but dammit if you can't dig better than the best of us"
> Trans Miner is made the Queen of Coal and Donald Trump poops his pants with rage
> The End

[_aestheticprimal_ @aestheticprimal]

there's a reason why coffee and cigs hit different than RedBull and Zyn.

because it's way more than just caffeine and nicotine

people love to break it down as different delivery mechanisms of caffeine and nicotine

but it's way more than that.

Coffee and Tobacco both contain a decent amount of beta-carbolines, these are alkaloids with pretty potent MAO inhibiting properties.

What does this mean?

They inhibit the oxidation of monoamines like Dopamine, Norepinephrine and Serotonin which normally happens through MAO-A and MAO-B

The result is a much more RAW feeling from classical coffee and tobacco, that can't really be compared to other caffeine or nicotine sources, especially when isolated.

As a bonus this also turns coffee and tobacco more neuro-protective.

MAO inhibition leads to reduced neuro-inflammation simply because when each monoamine is oxidized, it's metabolite is inflammatory.

(a few of the first pharmaceutical anti-depressants were MAO inhibitors btw)

[Zack Silverstone @ZackSilverstone]

@DelusionPosting >The surgery has a 50/50 chance of success.

>20 consecutive success streaks.

That guy has magic hands. I'm going with that guy.