Genes & Development

High-quality research in molecular biology, cancer biology, development, and related fields.

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[Genes & Development @GenesDev]

🚨 NEW ISSUE ALERT!!! 🚨

New Research articles online now at Genes & Development!

Also in this issue, two additions to our collection of Reviews on Cancer Metabolism, and more...

Click here to learn more:
➡️ https://t.co/kka7UPfwR6

[Genes & Development @GenesDev]

🆕 ADVANCE ONLINE 🆕

REVIEW: Architectural logic of the 3D genome: mechanisms of dysregulation and emerging cancer therapeutics
By Smith et al. and Yu (Sunny) Liu
➡️ https://t.co/KbtVTqSoXo

@YuLiu_Sunny @CeiFccc @FoxChaseCancer @FCCCAcademics
#cancer #epigenetics #chromatin

[Genes & Development @GenesDev]

ON THE COVER: MYC-PVT1-derived Firefox and Honeybadger regulate MYC-driven oncogenesis
Artwork by by Jianhua Zhao

Learn more in these complementary studies by Anindya Bagchi’s group:
➡️ https://t.co/CuXfl5IZZc

[Genes & Development @GenesDev]

🆕 ADVANCE ONLINE 🆕

RESEARCH PAPER: Mitotic MAX bookmarking drives MYC-dependent hypertranscription at TBP-bound promoters
By Gonzalez et al. and Pablo Navarro
➡️ https://t.co/upQkYkgKNk

@pablonavarroLAB @institutpasteur
#transcription #transcriptionfactor #mitosis #MYC

[Genes & Development @GenesDev]

🎙 G&D Voices: Author Lluis Morey 🎙

G&D continues to inspire scientists and publish influential research. G&D author, Lluis Morey, tells us why he chooses to publish in G&D.

[Genes & Development @GenesDev]

🆕 ADVANCE ONLINE 🆕

RESEARCH PAPER: mTOR inactivation governs adaptive survival to ribosome biogenesis deficiency
By Fan et al. and Marikki Laiho
➡️ https://t.co/YrJ27oAtqZ

@JohnsHopkins
#cancer #ribosome #translation #mTOR

[Genes & Development @GenesDev]

🌟 G&D SPOTLIGHT 🌟
G&D is pleased to present a collection of recent articles on gene regulation, RNA processing, and chromatin.

Learn more about the molecular mechanisms shaping gene expression and cell function:
➡️ https://t.co/xY7inmuN6H

[Genes & Development @GenesDev]

🆕 ADVANCE ONLINE 🆕

REVIEW: Regulatory circuits that build and sustain noninfectious granulomas
By Ridky et al. and Thomas Leung
➡️ https://t.co/IMeA53IBe9

@realthomasleung @Penn
#cancer #inflammation #granuloma

[Genes & Development @GenesDev]

🆕 ADVANCE ONLINE 🆕

RESEARCH PAPER: Multiple quality control checkpoints safeguard small nuclear RNA biogenesis and prevent assembly of aberrant spliceosomes
By Ma et al. and ens Lykke-Andersen
➡️ https://t.co/9wff0G5xbk

@UCSanDiego
#RNA #RNAdecay #RNAsplicing

[Genes & Development @GenesDev]

RESEARCH PAPER: Nuclear type I myosins actively support nucleolar and nuclear structure and function
By Peng et al. and Brian Freeman
➡️ https://t.co/E0Oc57VB6K

#genome #nucleus #myosin

[Genes & Development @GenesDev]

RESEARCH PAPER: Human PIF1 clears secondary DNA structures by coupled DNA unwinding and rewinding activities
By Jayachandran et al. and Petr Cejka
➡️ https://t.co/sbX1wtShKJ

@BellinzonaIrb
#DNA #DNArepair #DNAsynthesis #helicase

[Genes & Development @GenesDev]

🎙️ G&D Voices: Author Anindya Bagchi🎙️

Two complementary studies, one complete story.
G&D Author, Anindya Bagchi, tells us about why G&D was the right home for their work.

Learn more here:
➡️ https://t.co/5JlAG312Gg

[Genes & Development @GenesDev]

RESEARCH PAPER: Honeybadger, a PVT1-derived micropeptide, is a critical negative regulator of RAS–MAPK signaling in MYC-driven tumors
By Paithane et al. and Anindya Bagchi
➡️ https://t.co/INNHpLZPgG

Also read:
➡️ https://t.co/wGswNhUkFa

#cancer #MYC #KRAS #lncRNA

[Genes & Development @GenesDev]

RESEARCH PAPER: Firefox, a protein encoded by circular PVT1, is essential for MYC-driven oncogenesis
By Tiwari et al. and Anindya Bagchi
➡️ https://t.co/wGswNhUkFa

Also read:
➡️ https://t.co/INNHpLZPgG

#cancer #MYC #KRAS #lncRNA

[Genes & Development @GenesDev]

CANCER METABOLISM REVIEW: Dangerous liaisons: interactions between cancer cells and adipocytes as drivers of cancer progression
By Carolina Dehesa Caballero and Almut Schulze
➡�� https://t.co/eYbyEMR23I

@almut_schulze @MetaboholicsLab @HeidelbergU @DKFZ
#cancer #metabolism

[Genes & Development @GenesDev]

OUTLOOK: Cycling off: a novel mechanism for differential cell cycle-dependent histone gene expression
By Lauren Hodkinson and Erica Larschan
➡️ https://t.co/B5CTEJAPc9

Also read:
➡️ https://t.co/rFfrZ40NTa

@EricaLarschan @laureninthelab @BrownUniversity
#histone #mRNA

[Genes & Development @GenesDev]

RESEARCH PAPER: Temporal gating dictates stress-induced transcript export from the nucleus
By Helton et al. and Stephanie Moon
➡️ https://t.co/v7pqUt6YKn

@smslmoon @umichrna @umichmedicine
#mRNA #stress #RNAexport

[Genes & Development @GenesDev]

📽️ G&D Tapes 📽️

G&D Author, Kei Ishiguro, tells us about how the MEIOSIN-STRA8 interaction reinforces meiotic transcription and facilitates meiotic progression.

Read the full story:
➡️ https://t.co/XfL9DvcDKD

@IshiguroL
#celldivision #transcription #vertebratedevelopment

[Genes & Development @GenesDev]

RESEARCH PAPER: Multimerization of ELAV in Drosophila is essential for directing neuronal alternative splicing and polyadenylation programs
By Dix, McQuarrie, Bräuer et al. and Matthias Soller
➡️ https://t.co/nxjcO0BeYU

#RNAprocessing #neuron #Drosophila

[Genes & Development @GenesDev]

📽️ G&D Tapes 📽️

G&D Authors in the Higuchi-Sanabria lab tell us about how the neuronal expression of the chromatin reader BET1 influences aging.

Read the full story:
➡️ https://t.co/pZrDc6KeX9

@NaibedyaDutta @UniversityofSo5 @USCLeonardDavis
#neuron #chromatin #aging

[Genes & Development @GenesDev]

RESEARCH PAPER: MEIOSIN retains a STRA8-independent activity that contributes to meiotic gene activation across vertebrates
By Shimada et al. and Kei-ichiro Ishiguro
➡️ https://t.co/XfL9DvcDKD

@IshiguroL
#celldivision #transcription #vertebratedevelopment