ecDNA are rogue genetic material that amplify genes, contribute to treatment resistance and drive genomic heterogeneity. We report on the Origins and impact of extrachromosomal DNA today in @Nature https://t.co/TnMno4AZhU
One of the most frequent questions I hear about ecDNA is "why does it matter how oncogenes are amplified?"
These three amazing papers out today answer that and many more questions. Particularly, check out how the unique biology of ecDNA exposes a therapeutic vulnerability! 👇3⃣
Today #CancerGrandChallenges team eDyNAmiC and their international collaborators published 3️⃣ papers in
@Nature 📣
They show the prevalence of ecDNA in cancer, identify fundamental mechanisms and an actionable target now being tested in the clinic.
More: https://t.co/lx5dtVlyDK
We were thrilled to host aspiring science A-level students in our labs as part of the STARS programme funded by the @CRUKCOLcentre
https://t.co/wshVheBT5a
Thank you to all our volunteer demonstrators and mentors… 🧵
@uclnews@uclmedsci
📢📢Image competition!! @CRUKCOLcentre, @UCL, @QMUL, @QMBCI, @KingsCollegeLon, @TheCrick DEADLINE FRIDAY 22/3 !
The photo can be anything that looks scientific 👩🔬👨🔬. Maybe someone working on a script 👨💻👩💻 or a cool staining you want to show off🔬🦠🧫
👇👇
https://t.co/EuDhiAJvzd
City of London Centre image competition just opened! Please participate by 22 Mar, it’s open to everyone associated with CoL Centre. Find out prize for winners and how to participate https://t.co/Is8LNZXHQc
City of London Centre image competition just opened! Please participate by 22 Mar, it’s open to everyone associated with CoL Centre. Find out prize for winners and how to participate https://t.co/Is8LNZXHQc
"[Cancer Grand Challenges is] one of the most important international research partnerships in cancer science." 🌎
Incredible to see Lord Simon Stevens, Chair of @CR_UK, calling on the UK government to support #CancerGrandChallenges - thank you!
Meet Chris Bailey 👉 Specialist Registrar in #Haematology & Clinical Research Fellow at @TheCrick.
He told us about his work on #ecDNA & how this molecule challenges traditional models of #tumour evolution & drug resistance: https://t.co/ULfiJSX0Pl
#NPAW2023 | @cbailey_58
I had an incredible time speaking to budding scientists and reminiscing the time I had spent visiting labs back in the day! Hopefully I've convinced them that STEM is the way forward 👩🔬🧬🔬🧪
Many thanks to all the organisers and lab hosts involved in @uclcancer/@CRUKCOLcentre science taster week! The students had a great experience which exposed them to plenty of new and exciting opportunities 🌟
A study in @TheLancet from @cbailey_58, @dremmacbw, @DavidLVBauer and others shows the importance of the asymptomatic COVID testing for NHS staff we provided with @UCLH@UCLHResearch and HSL. It also offers a blueprint for future NHS-academic partnerships.
https://t.co/yJHMhZvPpH
Future entrepreneurs?
Many questions at the #EACR2023 “Meet the Expert” session (x2) on start ups and other opportunities beyond the bench.
These topics should definitively be part of the training of new researchers.
@EACRnews
On this day in 1953, Francis Crick, James Watson and Rosalind Franklin published the structure of DNA – the molecule that contains the blueprint for how we all grow and develop – in @Nature. Here is a thread on how this has led to a revolution in healthcare some 70 years on.
Excited to share our recent @SwantonLab@NickyMcGranahan & @MariamJHanjani lab work on the genomic evolution of non-small cell lung cancer metastases in #TRACERx, out @Nature
https://t.co/bmV9Q0cySW
A quick thread [1/13]
Dive into the data behind the landmark #TRACERx study 🔍
📅 Nine years of research
👥 800+ patients
️🧑🔬 250 investigators
🏥 13 hospital sites.
Read more about the study and what it means for future lung cancer patients: https://t.co/TxlTFdSLta
@TheCrick@UCL
This is consistent with our companion papers, which show the association between large recent subclonal expansion, metastasising subclones and poor clinical outcomes. https://t.co/x6fntrEkym https://t.co/bmV9Q0cySW