Giovanni L. Burke, PhD

PhD. The Greenblatt Lab, @MoGen_Grad, University of Toronto •🇨🇦 Bassist

[Cell Reports @CellReports]

ZNF121 recruits YTHDF2 to modulate mRNA stability dlvr.​it/TVptPg

[Giovanni L. Burke, PhD @Gio_Burke]

I'm happy to share that my paper has been published in @CellReports. We identify ZNF121 as an RNA-binding cofactor for the m6A reader protein, YTHDF2. ZNF121 promotes YTHDF2s binding to shared targets independent of m6A, modulating target stability. https://t.co/A2zlgefbxo

[bioRxiv Molecular Biology @biorxiv_molbio]

ZNF121 recruits YTHDF2 to modulate mRNA stability https://t.co/rF6nqAYMqI #biorxiv_molbio

[Trends in Genetics @TrendsGenetics]

The very early evolution of biological complexity https://t.co/23rSypNYpw

[Giovanni L. Burke, PhD @Gio_Burke]

As a companion to our large-scale study in Molecular Cell (https://t.co/bEtJ5NUsgK), we have published a focused story on one particular C2H2-Zinc Finger protein, highlighting its role in m6A biology by interacting with the m6A/m6Am eraser, FTO. https://t.co/BCTWLJdJp1

[Giovanni L. Burke, PhD @Gio_Burke]

Check out our new study in Molecular Cell identifying C2H2-Zinc Finger proteins as bona fide RNA-binding proteins, and exploring the roles that some members of this broad class play in post-transcriptional regulation of RNA, using a multi-omics approach! https://t.co/bEtJ5NUsgK

[Giovanni L. Burke, PhD @Gio_Burke]

Check out our new publication exploring how sumoylation relates to heat tolerance in yeast!
https://t.co/jW73FwB9aB

[Alex Palazzo @ribonucleicacid]

Go Eliza! #TREnD2022

[Priya Srivastava, PhD @PriyaSri576]

I made this SciArt during covid pandemic thinking about how powerful RNA molecule is…RNA can be a problem (deadly virus) and solution (Effective RNA vaccine), leading the world from doom to boom in seconds🤯 finally displaying my Art @trendrna https://t.co/ut4r13Etnw #TREnD2022

[TREnD @trendrna]

NEW: For #TREnD2022, we've assembled an amazing panel of scientists from both academia and industry to facilitate a conversation and help answer our questions about which path might be best for you in two discussion sessions!

Register NOW @ https://t.co/PvXfHxAVG6

[TREnD @trendrna]

BREAKING: #TREnD2022 is registration is officially OPEN!

Join us virtually for a trainee-oriented two days of networking, poster & oral presentations, RNArt, a Lunch&Learn session, & a Keynote from Dr. Oliver Rando!

Register & submit your abstracts @ https://t.co/vLaTIMQVQE 🔬

[Toronto Star @TorontoStar]

#Opinion: "Graduate students and post-doctoral fellows, who are responsible for most of the lab-based research in this country, are one group that deserves far more financial support, particularly in the face of rising inflation."

✍️Writes @MarkLautens
https://t.co/wO8xllOiEJ

[Giovanni L. Burke, PhD @Gio_Burke]

https://t.co/Hpir3Sb5i0

[Giovanni L. Burke, PhD @Gio_Burke]

@UofT UCheck???

[RNA Therapeutics Institute @RTI_UMassChan]

Together with @ScienceLIVEUMMS we put together an infographic & resources to explain COVID-19 mRNA vaccines: how they work & why they are safe, to dispel some of the common rumors and misinformation that have been circulating. 👩🏾‍🔬💉Please RT!

[bioRxiv @biorxivpreprint]

SARS-CoV-2 Nucleocapsid protein attenuates stress granule formation and alters gene expression via direct interaction with host mRNAs https://t.co/KtPJSq6h1A #bioRxiv

[David R. Liu @davidrliu]

We report RNA base editors that enable targeted conversion of A to m6A in endogenous RNAs in human cells in @NatureBiotech today. We used nuclear-localized dCas13 fused to a truncated METTL3 methyltransferase to achieve high-specificity A>m6A editing.
https://t.co/kihk9mU0ih 1/2

[The Insurgents @insurgentspod]

this aged well @neeratanden

[Cell @CellCellPress]

New Article online now at Cell: A Unified Model for the Function of YTHDF Proteins in Regulating m6A-Modified mRNA https://t.co/hDwL86fQ9W

[Glen E. McGregor @glen_mcgregor]

Here are the modeling charts projecting COVID-19 scenarios in Canada.