Caleb Grenko

Formerly @PennMedicine CBICA, @genome_gov MGMGB, and current @MayoClinic MD-PhD trainee. Poll worker, serial hobbyist, life-long learner, and always a Wildcat

[Caleb Grenko @grenkoca]

@ATinyGreenCell Why does it feel like I’m re-discovering what a “conflict of interest” is from first principles

[Caleb Grenko @grenkoca]

@ATinyGreenCell You definitely have to ask “if this policy gets implements, what does this person gain.”

You can’t hoard the gold and still be the knight in shining armor.

[Will Bredderman @WillBredderman]

Worst of all, gym classes are making them run miles an Uber could cover in less than a minute.

[Caleb Grenko @grenkoca]

Hey google play “I’ll Believe in Anything” by Wolf Parade

#Olympics2026

[Caleb Grenko @grenkoca]

@LinkedInHelp I mean this is sort of just a UI gripe, not specific to my account or a literal error. Thanks though- happy to share my thoughts for a consultant fee :)

[Caleb Grenko @grenkoca]

CHIP affects nearly everyone as we age.

We made a better way to detect it. Here’s how 👇

[Sam Crofts @Sam_JC_Crofts]

𝗜𝗻𝘁𝗿𝗼𝗱𝘂𝗰𝗶𝗻𝗴 𝗖𝗢𝗠𝗘𝗧 ☄️
We describe a fundamental principle of how clonal expansion shapes DNA methylation landscapes. We use this to detect clonal hematopoiesis - a major risk factor for cancer & CVD. ☄️is mutation-agnostic & scalable: https://t.co/Tl2MeUPeXg🧵👇

[Caleb Grenko @grenkoca]

@tangming2005 It should be noted that domain knowledge should supersede this point, and an appropriate housekeeping gene should be selected *for that experiment*

If you are doing a glucose challenge in glucose-responsive cells, it's okay that GAPDH changes.

[Caleb Grenko @grenkoca]

Oh DeepSeek stole your tech, OpenAI? Are you sure they didn’t just scrape it without permission?

[Caleb Grenko @grenkoca]

I'm forever in love with the Fuji XPan crop (65:24)

[Caleb Grenko @grenkoca]

I'm reviving my twitter solely for my photography

[Caleb Grenko @grenkoca]

… at this time of year, at this time of day, in this part of the country, localized entirely within my back yard?

[Caleb Grenko @grenkoca]

Not Antibiotics? Not Corticosteroids? Not Chemotherapies? We used to quake in fear of fatal infections and aggressive cancers....

I'm not saying that GLP-1 agonists aren't important, but calling them them "the most important drug class breakthrough in history" is sensationalist.

[Eric Topol @EricTopol]

The GLP-1 drugs are the most important drug class breakthrough in medical history. We're still learning how they have such broad impact, especially about their anti-inflammatory effects, systemically and in the brain
https://t.co/jZ49W1QItw
A new feature @Nature, by @marilenharo

[Caleb Grenko @grenkoca]

A brief overview:

1) We conducted a 24 hour glucose challenge for human pancreatic islets

2) Over those 24h, we profiled major islet celltypes using scRNA-seq

3) We nominated genes involved in insulin production and secretion and profiled four of them using CRISPRi

[Caleb Grenko @grenkoca]

How do human pancreatic islets respond to a 24h glucose challenge? Look at our new paper to find out!

Single-cell transcriptomic profiling of human pancreatic islets reveals genes responsive to glucose exposure over 24 h

#diabetes #genetics #paperalert

https://t.co/5q9oDAqCjv

[Caleb Grenko @grenkoca]

How do human pancreatic islets respond to a 24h glucose challenge? Look at our new paper to find out!

Single-cell transcriptomic profiling of human pancreatic islets reveals genes responsive to glucose exposure over 24 h

#diabetes #genetics #paperalert

https://t.co/5q9oDAqCjv

[Caleb Grenko @grenkoca]

My wordle after I hit
⬛⬛🟩🟩🟩

[Randall Munroe @xkcd]

Sitting in a Tree https://t.co/AScXLmeGUB

[Caleb Grenko @grenkoca]

@BizzlePep It's the champagne of beers. Idk what more you want man

[Caleb Grenko @grenkoca]

The AI when I tell it that IPAs taste like lawn trimmings

[Kevin Verstrepen @KevinVerstrepen]

Our new paper “Predicting and improving complex #beer flavor through #MachineLearning learning” is out in @NatureComms ! Read how we used #AI to make #belgian 🍺 even better: https://t.co/8LtHBWf2eS Comments in @guardian https://t.co/KfOcMp7Lr6 @KU_Leuven @VIBLifeSciences

[Caleb Grenko @grenkoca]

@NHGRI_Director What's Dr. Starbright Green's opinion on Dr. Ostrander's work with dog genomics? This feels like a conflict of interest

[Caleb Grenko @grenkoca]

@bedevilledcat @timchartier would be a good reference