Top Tweets for #BaFF
🚨#FDA Approval Update | The approval of #atacicept, the first dual #BAFF/#APRIL inhibitor for #IgA nephropathy
💡Highlights how targeting disease-driving immune pathways may help slow progression before irreversible kidney damage occurs.
#IgAN #Nephrology #Immunology #DrugDiscovery
💊#FDAApproval Update | #The FDA has granted accelerated approval to #Trutakna (#atacicept-vymj) to reduce proteinuria in adults with primary #IgANephropathy (#IgAN)
💡Trutakna is the first approved dual #BAFF/#APRIL inhibitor, targeting two key cytokines involved in the autoimmune mechanisms underlying IgA nephropathy.
🩺IgA nephropathy is the most common form of primary glomerular disease worldwide and a leading cause of chronic kidney disease. Persistent #proteinuria is a key predictor of progressive kidney function decline.
📊ORIGIN Phase 3:
🔹Once-weekly subcutaneous self-administration
🔹46% reduction in proteinuria (24-hour urine to protein-to-creatinine ratio) from baseline at 36 weeks
🔹68.3% reduction in Gd-IgA1 by week 36
🔹81% of patients achieved complete resolution of dipstick hematuria
💊Provides a novel treatment option for patients at risk of progressive renal impairment
💡As the IgA nephropathy treatment landscape continues to evolve, targeted immune modulation is emerging as a key strategy for slowing disease progression.
#CKD #ChronicKidneyDisease #Nephrology #Autoimmunity #RareDisease #DrugDiscovery #MedicinalChemistry
💊#FDA承認 アップデート | FDAは、原発性 #IgA腎症（#IgAN）成人患者のタンパク尿を軽減する治療薬として、#Trutakna（#アタシセプト-vymj）を迅速承認（Accelerated Approval）しました。
💡Trutaknaは、#BAFF と #APRIL の両方を阻害する初の承認薬であり、IgA腎症の自己免疫機序に関与する2つの重要なサイトカインを標的とします。
🩺IgA腎症は世界で最も一般的な原発性糸球体疾患であり、慢性腎臓病（CKD）の主要な原因の一つです。持続的な #タンパク尿 は、腎機能低下の進行を予測する重要な指標とされています。
📊第3相 ORIGIN試験
🔹週1回の皮下自己投与
🔹36週時点で、24時間尿タンパク/クレアチニン比（UPCR）がベースライン比46%減少
🔹36週時点でGd-IgA1を68.3%減少
🔹患者の81%で試験紙法による血尿が完全消失
💊進行性腎機能障害のリスクを有する患者に新たな治療選択肢を提供
💡IgA腎症の治療戦略が進化を続ける中、標的免疫調節は疾患進行を抑制する重要なアプローチとして注目されています。
#CKD #慢性腎臓病 #腎臓病学 #自己免疫疾患 #希少疾患 #創薬 #医薬品化学
💊#FDAApproval Update | #The FDA has granted accelerated approval to #Trutakna (#atacicept-vymj) to reduce proteinuria in adults with primary #IgANephropathy (#IgAN)
💡Trutakna is the first approved dual #BAFF/#APRIL inhibitor, targeting two key cytokines involved in the autoimmune mechanisms underlying IgA nephropathy.
🩺IgA nephropathy is the most common form of primary glomerular disease worldwide and a leading cause of chronic kidney disease. Persistent #proteinuria is a key predictor of progressive kidney function decline.
📊ORIGIN Phase 3:
🔹Once-weekly subcutaneous self-administration
🔹46% reduction in proteinuria (24-hour urine to protein-to-creatinine ratio) from baseline at 36 weeks
🔹68.3% reduction in Gd-IgA1 by week 36
🔹81% of patients achieved complete resolution of dipstick hematuria
💊Provides a novel treatment option for patients at risk of progressive renal impairment
💡As the IgA nephropathy treatment landscape continues to evolve, targeted immune modulation is emerging as a key strategy for slowing disease progression.
#CKD #ChronicKidneyDisease #Nephrology #Autoimmunity #RareDisease #DrugDiscovery #MedicinalChemistry
@sipmollywater My twin music isn’t only good but it’s organic he works on his own shit when he ain’t inna Stu he on his laptop and mic trying to make sum, I feel like all of these pages needs to push him and he ain’t a clone of anyone #baff #yves!
It happens to us all Charlie!
Hopefully you will get a groomer like @GinoCitronni who gives lots of #SpecialTreats & fuss?
I absolutely love being groomed…. It’s not as good as a #Baff but it’s wonderful
Isky’s less keen #OfCourseHeIs 🙄 #IskyHatesBaffs
Sending a #Before to your mum of Isky as she loves him curly ♥️♥️
@24_libs @GinoCitronni Bat adores being clipped, he loves any & all fuss
Tomorrow he’s getting a #Baff his #FavouriteThing
Isky however won’t be happy #IskyHatesBaffs
We think you look very smart….
It must be the time of year?
Our #FurThief @GinoCitronniitronni is coming on Thursday to scalp us
We think we look lovely…… mum thinks we look like a pair of wild wooly mops #RoodVeryRood
I’m hoping for a lovely deep soapy #Baff with lots of conditioning massage & extra conditioning massage 🤞🤞
Isky hates Baffs & is hoping not!
One of us will be right 😂😂😂
#GinoTheFurThief
My month-long trip to Canada is coming to an end. I will always cherish and keep this travel memory in my heart. I am truly grateful, and I will remember it foreve.
#Canadatrip
#Calgary
#Baff
#Montreal
B細胞むりやり7Days生かして分化させる系を安定させるの…まーーーーじで安定するまで大変でしたよ
#特にTLRもIFNも使わない方
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