Top Tweets for #GLP1r
GPCRvp, a GPCR-specific variant impact predictor, decodes GLP1R missense variants using molecular dynamics + AI. It sharply reduces false positives vs AlphaMissense and improves prediction of GLP 1 drug response. #GLP1R #GPCR #Diabetes #Obesity https://t.co/4IaPzlDMY5… @DiabetologiaJnl
Italian biopharma #Menarini pushes into #obesity via Gan & Lee deal that gives it twice-monthly #GLP1R #bofanglutide, which reported positive Ph III data in China and Ph II U.S. data in May https://t.co/8jJ6LnkXoL
🔥Hot Off the Press |🧬Not all patients respond equally to #GLP1 therapies. Why?
New research in #Nature shows:
🔹Genetic variation in #GLP1R impacts weight loss efficacy
🔹GIPR variants linked to nausea/vomiting (e.g. #tirzepatide)
🔹Non-genetic factors still play a major role
MedChemExpress offers GLPR-related tools for research use: https://t.co/HadqqfVoQG
#Semaglutide #Genomics #WeightLoss #Obesity #GLP1RAgonist #SideEffects
Precision #obesity care is here:
Variants in #GLP1R and #GIPR influence response to #Semaglutide and #Tirzepatide—affecting both weight loss (~0.76 kg/allele) and side effects.
👉 Time to move toward #genotype-guided, precision prescribing.
@otojournals EIC @cescmalbach discusses "Assessing the Impact of GLP-1R Agonists in Post-sinus Surgery Management" with senior author Mohamad R. Chaaban, MD, and Associate Editor Dana L. Crosby, MD, in this month's OTO Journal Podcast.
#Rhinosinusitis #GLP1R #ENT #ENTX #AAOHNS
Looking forward to this exciting webinar on Jan 12th with Drs Emily Gallagher and Eric Orlendorf! #glp1r in #netcancers @TheEndoSociety @NANETS1 @CureNETs
Join our faculty, Emily Gallagher, MD, PhD; @PoHienEar; and Eric Orlendorf, MD, on Monday, January 12 to learn how to evaluate the risks and benefits of using GLP-1 receptor agonists in patients with neuroendocrine tumors. Register now: https://t.co/FlFgBEjdLR
💊FDA Approval Update |🙌A big step in weight-loss science!
#FDA approval of the #Wegovy oral GLP-1 pill opens new possibilities for effective and non-injectable #obesity treatments.
🌟MedChemExpress provides #Semaglutide for research use.
#WeightLoss #GLP1 #GLP1R #WegovyOral
📰New & Featured | November New Releases
🚀1,000+ New Bioactive Molecules, targeting #WEE1 #HPK1 #MDM2 #TRPA1 #PARK7 #GLP1R
✔Reduce trial-and-error in early discovery
✔Access phase-advanced, high-selectivity research tools
#Oncology #Neuroscience #DrugDiscovery #ResearchTools
I’m super excited to share our latest work on #GLP1R expression in neuroendocrine neoplasms:
https://t.co/Wad8s7roJ2
@EndoOncology
So thankful to be working with these wonderful people @UIowaCancer ! 🫶
Merck struck a $2 billion deal with Hansoh for its small molecule GLP-1 receptor agonist. Is the deal really about weight loss? GLP-1 receptor agonist can have impact on DCs. Merck's deal could serve dual purposes: weight loss and cancer.
GLP-1R agonists can affect dendritic cell migration, maturation, and antigen presentation. Some research indicates that GLP-1R agonists can modulate the inflammatory response by influencing dendritic cells, potentially reducing inflammation in certain conditions.
https://t.co/cwuc7BNcyS
#GLP1R #Pericyte
GLP1R agonist (Exendin-4) relaxes cardiac #Pericyte & dilates constricted capillaries in oxygen-glucose-derived perfused🐭right ventricle wall
A role of KATP channel Kir6.1
GLP1R antagonist (Exendin-9) blunt the benefits of #IschemicPreconditioning on rat🫀ischemia/reperfusion injury (capillary perfusion volume)
NG2+ Pericyte Kir6.1 KO abolishes IPc benefits on Infarct size post-IRI
David Attwell lab bioRxiv 2025
https://t.co/FDsvuIqgAL
Visualize membrane #GLP1R in fixed/live cell & animals
LUXendin 492/551/555/615/645/651/762
Fluorescent Exendin4(9–39)
retro-orbital or s.c. injection
Also act as GLP1R antagonists
What are those perivascular labeling (beyond islets) in LUXendin-infused pancreas? Pericyte!?😍
@LinnemannLab @JACS_Au 2022 @ACSPublications
https://t.co/O3r7sJaU8z
These GLP1R probes are also commercially available!
https://t.co/PgsGO2waIl
🚨What if your #Diabetes meds could fight addiction too?🧠💥New review shows #GLP1R agonists slash #Alcohol, #Nicotine, stimulant, & opioid cravings in animal models🐀➡️Humans next? 🚀Time to rethink #Addiction treatment! @IJMS_MDPI @MDPIOpenAccess
https://t.co/95nNMV056F
🚨What if your #Diabetes meds could fight addiction too?🧠💥New review shows #GLP1R agonists slash #Alcohol, #Nicotine, stimulant, & opioid cravings in animal models🐀➡️Humans next? 🚀Time to rethink #Addiction treatment! @IJMS_MDPI @MDPIOpenAccess
https://t.co/95nNMV056F
Video Abstract📺Dual activation of #GCGR/#GLP1R #signaling ameliorates #intestinal #fibrosis via #metabolic regulation of #histone #H3K9 #lactylation in #epithelial cells. https://t.co/CcEe5cvJtw.
🚨What if your #Diabetes meds could fight addiction too?🧠💥New review shows #GLP1R agonists slash #Alcohol, #Nicotine, stimulant, & opioid cravings 🐀➡️Humans next? 🚀Time to rethink #Addiction treatment! @IJMS_MDPI @MDPIOpenAccess https://t.co/95nNMV056F
Do #GIPR agonists & antagonists enhance #GLP-1R mediated #WeightLoss via the same mechanism? With help from Promethion #Metabolic Cages, a Nature study found that only GIPR antagonists require GLP-1R signaling.
https://t.co/mk7tPRkkLf
#Obesity #Metabolism #GIP #GLP #GLP1R
GLP1R medications show remarkable efficacy in T2D & obesity, but inter-individual responses vary. Precision medicine & biomarkers guide treatment, though widespread screening may not be cost-effective. #Diabetes #PrecisionMedicine #GLP1R
https://t.co/YPv67FrcUC
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