Top Tweets for #HiPSC
In this study, researchers presented a novel microphysiological system using a compartmentalized microfluidic device to integrate co-cultured #hiPSC-derived cardiomyocytes and sympathetic neurons.
🔗 https://t.co/FHR9Jbi9EU

In an early-stage randomized trial, the safety and efficacy of #intramyocardial injection of #hiPSC-derived #cardiomyocytes in patients with advanced heart failure were evaluated.
https://t.co/5loeMebGVU
🎉 @STEMCELLTech and @CCRM_ca announced a partnership to expand access to high-quality #hiPSC starting materials, giving cell therapy developers worldwide a faster, lower-risk path from research to the clinic.
Learn more about the partnership: https://t.co/BmBjW35Ij5

🎉 @STEMCELLTech and @CCRM_ca announced a partnership to expand access to high-quality #hiPSC starting materials, giving cell therapy developers worldwide a faster, lower-risk path from research to the clinic.
Learn more about the partnership: https://t.co/s32PENezxX

This review authored by Drs. Wuqiang Zhu and @mayoclinic collaborators focuses on #cardiomyocyte alignment as a critical design requirement for improving electrophysiological and regenerative outcomes in #hiPSC-cardiomyocyte based cardiac #CellTherapy. https://t.co/sESFCqBoST
#OpenAccess 🔓

Researchers at @AllenInstitute led by Drs. Caroline Hookway and Susanne Rafelski develop a #hiPSC-based platform to study epithelial-to-mesenchymal transition, enabling standardized analysis of cell state changes across 2D and 3D models.
Learn more here:
🔖 https://t.co/O6Csu55fd0

We’re advertising for a post-doc & research assistant
@EdinburghUni
Combines #RNA & #hIPSC models to understand & correct early events in #MND. Come join us in this amazing city & great centre. Deadline:
PDRA: 12.6 @ https://t.co/Zaqh5sIwxw
RA: 16.6 @ https://t.co/tVRjyaWYYu

Researchers from University of Bordeaux and @Harvard alongside Drs. Pierre Nassoy and L. Mahadevan show that #hiPSC-derived epithelial cortinoids achieve reversible “superdeformability” through cytoskeletal bending and tilting, enabling large shape changes without loss of tissue integrity.
🔖 https://t.co/Dt2xhHrFkB

NAMPT #AbdominalAorticAneurysm
👤AAA
⏬NAMPT OXPHOS mitochondrial ETC #SmoothMuscleCell contractile phenotype
⏫Senescence of SMC + non-SMC
⏫B cell #PlasmacytoidDendriticCell
1⃣#ExtracellularVesicle derived from NAMPT-overexpressing #hiPSC-#MesenchymalStemCell or 2⃣P7C3 a NAMPT chemical activator
👉restores SMC NAD+
👉alleviates SMC senescence &🐭AAA
MSC-EV per se benefits, too🤓
@BioactiveMat 2023
https://t.co/Z7Q7gtVU9a

1) Built CellLens after getting tired of patching #microscopy repos for #cardiomyocyte videos.
Hybrid: optical flow + #VLM
So far:
• 0.03 BPM avg error
• 100% beat detection on 236 #hiPSC-CM videos
• Works on #fluorescence too
Looking for early testers DM me!
@mergedotclub
💥Excited for the publication: "Three-Dimensional Trilineage Differentiation Conditions for Human Induced Pluripotent Stem Cells"
🔗 https://t.co/Jp40SANw8C
📌 #hiPSC #3Dculture #endoderm #mesoderm #ectoderm #3Ddifferentiation #syntheticpeptidehydrogel

🧫 Scientists generated multiple #hiPSC lines with inducible ETV2 expression, and subsequently differentiated them into human-induced endothelial cells.
Learn more here:
https://t.co/B4yqjK4fYV

.@MCRI_for_kids collaborators including Drs. Svenja Pachernegg and Katie Ayers provide the first comprehensive transcriptional profile of #hiPSC-derived testis-like #organoids.
Check it out!
📝: https://t.co/GCUxKkQVLA
📙: @Dev_journal

.@PurdueNorthwest's Dr. Yang and colleagues developed #hiPSC-derived #organoid and assembloid models integrated with microglia, allowing in-depth exploration of microglial heterogeneity and neuroimmune interactions in human cell–based models. 🧠
🔗 https://t.co/heCJ1Tyt8z

#Postdoc Position available: #LongCovid '#PostVAC #autoantibodies #GPCRs #Assay development #hiPSC #cardiomyocytes big consortium #PERCOLATE, patient data and material, 2 year contract, highly interdiscilinary and international team (15 researchers)
[email protected]
💥Hot Papers from Brown University
@BrownUniversity
The publications can be accessed via the QRs. 🤝
#hiPSC #Cardiac #Cartilage #Neuromuscular #Osteoarthritis #Ligament #Extracellular_Vesicles #Electrospun #Scaffold #Cardiovascular #Bone #Electromagnetic_Fields

@soahleephd et al demonstrate that contact inhibition restricts #hiPSC-CM #proliferation via two independent mechanisms. Learn how #IGFBP2 supplementation can overcome these inhibitory cues at https://t.co/6mqBKub5Xz
@SeanM_Wu @Josheph_C_Wu @dtpaikPhD @Will_Goodyer

A high-fidelity protocol for #hiPSC-derived Fibrosa (Collagenous) vs Spongiosa (Glycosaminoglycan-producing) #ValvularIntersistialCell
Endocardial state +FGF2/BMP4/TGFB2➡️
Fibrosa subpopuylation: PRRX2 TIMP3 ITGA2 (most discriminative marker)
Endocardial state +FGF2 (low dose)➡️
Spongiosa subpopulation: LUM APOE
Spongiosa VICs produce higher GAG & Collagen than Fibrosa VICs on circularly stretched PGA/P4HB scaffold +TGFB2 !🥸
Gordon Keller lab bioRxiv 2025 @AmineMazineMD
https://t.co/vIiP8ECECf

#hiPSC-derived mononuclear phagocyte i.v. ▶️moderate neurobehavioral benefits (NOL/NOR) in Aged NSG (11~12 mo) or #AlzherimersDisease (4 or 9 mo) 5xFAD🐭
👉⏫GluR2/3+ Hippocampal Mossy cell#
👉⏬neuroinflammation & microglia activation (LAMP1)
👉No overt impact on Aβ
👉Revert Transcriptomic Age of multiple neural cells
➡️28 clock driver genes (shared >= 3 cell types)➡️Rac signaling🤓
Injected cells do not home to brain or survive in circulation, but stay in lung or other peripheral organs (Tail/Spleen/Heart/Kidney), likely altering the distant secretome that modifies plasma proteome
Fig. S7E: SC121+ human cells adhere on the luminal side of pulmonary artery, mimicking endothelium🧐
#AdvSci 2025 @AdvPortfolio
https://t.co/P1K6DS0KEY

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