Top Tweets for #MSystems
In #mSystems, researchers characterized the extensive proteome remodeling in the (p)ppGpp-null relA spoT mutant during late exponential and stationary phase and provided the first protein-level analysis of the stringent response in P. aeruginosa. https://t.co/0m4WNE6zH2
Researchers systematically compared DNA-, RNA- and total nucleic acid–based metagenomic sequencing libraries using the same clinical samples processed in parallel. They found that the 3 strategies did not provide equivalent information. #mSystems: https://t.co/qlzdnBWrmL
Natural, non-genetic variation among host cells can shape infection outcomes. In #mSystems: variability in hemoglobin content among individual red blood cells modulates nutrient consumption by Plasmodium falciparum, the most lethal malaria parasite. https://t.co/iW3HKDulvB
Plasmid transfer among bacteria is an important driver of the spread of antibiotic resistance. In #mSystems, researchers show that physical collisions between growing colonies enable the spread of plasmids carrying antibiotic resistance genes. https://t.co/zmyZtAlIEI
In #mSystems, researchers examined both tissue-associated bacteria & DNA methylation in paired tumor & non-tumor tissue from patients w/ colorectal cancer to identify microbial & host methylation patterns linked to tumor tissue & serrated-pathway cancers. https://t.co/GZEfxwBas1
High-throughput and quantitative mass spectrometry metabolomics show that Clostridioides difficile uniquely converts amino acids into at least 28 N-acyl amino acids, a metabolite family historically linked to diverse bioactivities. Learn more in #mSystems: https://t.co/VCqkxbkaxg
Individual gut microbiota-produced metabolites are sufficient to worsen disease in a mouse model of multiple sclerosis (MS). Targeting microbial metabolites or modifying diet-microbiome interactions may help reduce disease activity in MS. #mSystems: https://t.co/FVtWAq6ehw
Pandoomain, a Snakemake pipeline, automates the acquisition of genomes from NCBI, identifies proteins of interest using hidden Markov models (HMMs) and performs systematic domain annotation and gene neighborhood analysis. #mSystems: https://t.co/gRZlpWfcKl
The fitness of a phage that can modulate lysis timing in response to changes in host physiology is elevated in fluctuating feast-famine environments compared to more stable environments, which favor rapid lysis with a reduced burst size. #mSystems: https://t.co/M9hkBBGPSD
Host contamination makes the study of tumor-associated microbiomes via WGS difficult. HumanFilt, a new open-source tool designed for rigorous host-read removal, could help. Learn more in #mSystems: https://t.co/FySs3QmzHu
Compared to healthy adults, the gut microbiomes of elite athletes are enriched in pathways related to amino acid biosynthesis, glycolysis, fatty acid β-oxidation and quinone synthesis, which may be relevant for metabolic efficiency. #mSystems: https://t.co/kVqOOcERxL
New in #mSystems: Metric Learning for Statistical Inference (MeLSI), a novel machine learning framework that learns data-adaptive distance metrics optimized for detecting community composition differences in multivariate microbiome analyses. https://t.co/dwJYiUyTod
In coral reefs, dissolved organic matter (DOM) fuels microbial growth that harms corals. In #mSystems: new insights into how phages interact with DOM, showing that cell-associated phages are associated with more energy-rich organic compounds. https://t.co/SpvsMj8sAS
Leveraging biofilm isolates from a glacier-fed stream, researchers examined the nature and key bacterial traits that mediate competitive and positive interactions to uncover the drivers of bacterial interactions in stream biofilm communities. #mSystems: https://t.co/P4RklXwh6m
Freeze-thaw processes profoundly affect soil carbon storage by altering microbial communities. In #mSystems, researchers show that freeze-thaw strength regulates carbon density through microbial assembly processes and network clustering. https://t.co/v4TN7Oqo9Q
Climate change threatens Arctic permafrost with cycles of freezing & thawing. Researchers thawed frozen Svalbard active layer soil & found that half of the microbial diversity did not grow after thaw & that some groups grew disproportionately. #mSystems https://t.co/bt64uz6hyI
Microbes are critical for the decomposition and recycling of organic matter. In #mSystems, researchers show that blow fly maggots serve as an important source of decomposer taxa that significantly alter the cadaver microbiome following infestation. https://t.co/IBrShKES3x
The aceE gene, a crucial enzyme that links glycolysis and the TCA cycle, plays a vital role in regulating the normal physiological metabolism of Mycobacterium tuberculosis, affecting growth and biofilm formation via cell wall lipid remodeling. #mSystems: https://t.co/1pEdwQsedt
Prediction of optimal growth temperature (OGT) from genomic data allows for characterizing uncultivated microbes. This #mSystems study developed a novel OGT prediction model by curating OGT and genomic data of 2,869 bacterial species. https://t.co/fsvdnhkC9e
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