Top Tweets for #Merfish
Many thanks to Aniket from @vizgen_inc for a great week of Merscope training! #MERFISH #SpatialBiology
Spongebob and Patrick meet new friend- Merfy, the Merscope mascot!🐠🐠🐠
Excited to share our new Nature Communications paper! 🚀
We combined scRNA-seq + 3D MERFISH to build the first 3D spatial atlas of nkx2.5⁺ progenitors in the zebrafish heart field.❤️🐟
🔗 https://t.co/254JzgA1XQ
#SpatialBiology #MERFISH #SingleCell #Zebrafish
A @NeuroCellPress paper led by Kushal @UCBerkeley, Nicole&Victoria @UCSF in full collaboration with @shekharlab, Molecular and spatial analysis of ganglion cells on retinal flatmounts identifies perivascular neurons resilient to glaucoma https://t.co/QjeNMbQwWZ #retina #MERFISH
Online now: Molecular and spatial analysis of ganglion cells on retinal flatmounts identifies perivascular neurons resilient to glaucoma https://t.co/RddHnv3hn6
We are thrilled to share our latest work now published in @CellReports! We combined #scRNAseq and #MERFISH on mouse models of type 2 skin inflammation to uncover a critical basophil-fibroblast crosstalk axis in amplifying inflammation. A thread 🧵 1/11
A basophil-fibroblast pro-inflammatory axis fuels type 2 skin inflammation https://t.co/WsnWNRvVC9
Multiplexed FISH methods such as #MERFISH can image 1000s of unique RNA transcripts within single cells, and in turn define a massive diversity of cell types and states within intact tissues. 2/9
Join us on 5/28 to explore how Vizgen’s new MERFISH 2.0™ chemistry and the MERSCOPE Ultra™ Platform are advancing spatial genomics—unlocking new possibilities for FFPE and archived tissue samples.
Register here: https://t.co/qT5oplk6ZU
#SpatialBiology #MERFISH
A new Cell study introduces Perturb-FISH, combining CRISPR screening with MERFISH technology to map gene function in spatial context. The method reveals new genetic networks tied to cell behavior.
Read: https://t.co/RWtnHQxPJY
#MERFISH #CRISPR #SpatialBiology
A new pre-print study from researchers at @Stanford utilized the MERSCOPE® Platform to reveal how aging alters the function, morphology, and mRNA distribution of microglia.
Read the full pre-print: https://t.co/RmW36N6zni
#SpatialBiology #MERSCOPE #MERFISH
Sequencing 2541 individuals, we identified likely damaging mutations in 187 genes, almost none previously implicated in MM. Damaged genes showed widespread expression on spatial transcriptomics (#MERFISH) during neurogenesis.
🔍 MERFISH 2.0: Redefining #spatialbiology with enhanced chemistry:
✅ Improved RNA anchoring for transcript integrity
✅ Optimized probe binding for precision
✅ Enhanced read-out design for deeper insights
Get exclusive datasets: https://t.co/jm9Zv6HoFi
#MERFISH
Simultaneous analysis of single-cell gene expression and morphology provides new insight into how microglia change with age | bioRxiv | from Prof. Stephen Quake's lab @StephenQuake @Stanford https://t.co/GUjYUGzT7P #MERFISH #microglia
🔦 #MERFISH 2.0 enables high-resolution spatial transcriptomics, even in challenging fixed frozen PDAC tissue.
🔬 Through Vizgen Lab Services, Marco Genua (Fondazione Telethon) mapped the tumor microenvironment, overcoming RNA quality challenges.
🔗 https://t.co/uAf9jxCx1a
#Spatialbiology’s new era is here with MERFISH 2.0. From Surface Structures to Subcellular Depths, #MERFISH 2.0 redefines #spatialtranscriptomics by further advancing the proven & trusted
MERFISH chemistry.
🔍Explore real-world data & customer stories: https://t.co/njCwL5zC6s
Ecstatic to announce that I've been awarded a Marie Curie Postdoc Fellowship #MSCA to work with Don Canfield @Nordcee and alongside Jonathan Brewer @DambicDK to invesigate sponge anaerobic metabolism-associated pathways via targeted experiments coupled with #MERFISH @SyddanskUni
🔬 Explore the latest breakthroughs in spatial genomics with the newly updated Vizgen Webinar Playlist on YouTube!
Watch now to hear directly from experts leveraging #MERFISH & the MERSCOPE® Platform to address the latest challenges in spatial biology: https://t.co/yiuoZ8Fkkw
‼️FFPE is #spatialbiology’s triple threat: RNA degradation, cross-linking & autofluorescence.
#MERFISH 2.0 tackles low-abundance transcripts in degraded samples, like human kidney tissue, & reduces noise via tissue clearing.
👀Preview data & pre-order: https://t.co/VlsN5a6Wv5
🌟 Transforming #SpatialGenomics Research!
@vizgen_inc's #MERFISH technology makes groundbreaking discoveries in neuroscience, oncology, & more accessible to researchers worldwide. With 310+ publications (161 peer-reviewed), its global impact is undeniable.
Explore: https://t.co/SbMbuE9HfN
🛡️Skin is no barrier to acquiring #SpatialTranscriptomics data with MERFISH 2.0. In an #FFPE mouse skin study, #MERFISH 2.0 greatly improved transcript detection efficiency, revealing hidden insights into tissue structure and gene expression. Ready to discover more? Learn more: https://t.co/B9bOKC61NY
🌾Excited to share a new pre-print from researchers at the @JohnInnesCentre & @EarlhamInst !
Using @vizgen_inc's #MERFISH technology, the team resolved the expression of 200 genes to cellular resolution, uncovering remarkable insights into inflorescence development.
💡 Read more 👉 https://t.co/fjEDKxnI7o
#SpatialBiology #MERFISH #WheatResearch #Innovation
1/9 I am excited to share our pre-print on spatial transcriptomics in wheat spikes in collaboration with @AshleighSLister. Using MERFISH, we resolved the expression of 200 genes to cellular resolution. Check out the pre-print 👉https://t.co/Xt54n76kUX
Comparing Performance of Imaging-based #SpatialTranscriptimics methods
#CosMx vs #MERFISH vs #Xenium
1k vs 500 vs 339 plex
93-gene overlap
FFPE Human Lung/Mesothelium Tumor Tissue Microarray
CosMX▶️highest transcript counts/cell
Xenium▶️lowest FDR & closest biological cell shape
Cell type detection
CosMx 9
MERFISH 6
Xenium 14 (UM) 18 (MM)
scRNAseq Label transfer helps
Xenium MM▶️the highest F1 score (cell segmentation precision)
@kchenken bioRxiv 2024
https://t.co/iWbfAWsSWv@
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