Top Tweets for #Stat3
With tardy @tvarditherap phase I win, skin in STAT3 game plus GI https://t.co/gBGT3y5MK7 #biopharma #STAT3 #dermatology #gastrointestinal
🧠 Pancreatic cancer—cracked?
• KRAS + EGFR + STAT3 blocked together
• Complete tumor regression in mice
• No relapse >200 days
• Well tolerated, no major toxicity
• Preclinical, not a cure (yet)
📄 Liakia et al, PNAS 2025
#PancreaticCancer #KRAS #STAT3 #PROTAC #MVOnco
For mom, with all my ❤️
#TakeMyBreathAway #SARSCoV2 #SpikeProtein #COVID #LongCovid #PASC #SpikeSpikeBaby #ICanDoBadAllByMyself #TinyBubbles #DiamondsOnTheSoleOfHerShoes #Witchcraft #TYMP #STAT3 #cancer #pulmonology #oncology #MedTwitter #pandemicplaylist
https://t.co/zHbrcNL7qx
Nassal & colleagues identify a #STAT3 dependent mechanism to therapeutically promote the persistence of adaptive cardiac #hypertrophy & improve heart performance. Learn more at https://t.co/c2nGF6C8Lo
@HundLab @OhioStatePCB
Limitation of TCA Cycle Intermediates Represents an Oxygen-Independent Nutritional Antibacterial Effector Mechanism of Macrophages #HIF1α #STAT3 #MECFS #LongCovid
https://t.co/KrXOJ76Om7
List of some papers supporting elevated IL-6, increased #Th17 responses, or heightened #STAT3 activity in STAT6 knockout or deficient mice mimicing #STAT6 degradation:
1. glomerulonephritis model: https://t.co/cFqG0klsvL
2. EAE models with elevated IL-17: https://t.co/vleDtwXY78
3. γδ17 cells in fungal infection model: https://t.co/OxNaqzEEOg
4. Elevated IL-6 in LPS-induced acute lung injury: https://t.co/fy2qKvxpjN
5. Increased STAT3 phosphorylation in colitis-associated carcinogenesis: https://t.co/AlZ0gPO0Xf
6. PGE2 promotes Th17 by suppressing STAT6: https://t.co/YU5ShulLcv
7. STAT6 knock out mice Increase EAE
https://t.co/WwOH0c8JZB
🚨"Mechanisms of Dupilumab" Paper:
- IL-4Rα Q576R variant pathway reprograms Tregs into Th17-like Tregs via #GRB2->#MAPK->#IL6/#STAT3 destabilising Tregs
Conclusion:
R576 variant results in mixed #Th2/#Th17 inflammation + more severe disease
https://t.co/rGaJrOIuDf
IL-4Rα Q576R polymorphism surprisingly common⤵️
Results in increased severity of atopic dermatitis (AD) in a dominant manner (one R allele), leads to increased #GRB2 binding, more #STAT6-independent pathways.
R Allele Global Frequency ~30-35%, carriers %:
Caucasians, 10-20%
Asians, 16-24%
Hispanics, 40%
Blacks, 65-70%
A team led by @JablonskaLab of @unidue shows that targeting #STAT3 in #neutrophils reprograms them to an antitumor state, enhances cytotoxic CD8+ T cells, and suppresses tumor growth, representing a promising #CancerImmunotherapy strategy.
#STTT #OpenAccess: https://t.co/6eRj8BGdg2
Specific molecular pathway may fuel inflammation and tissue damage in #asthma: researchers report that a protein called EPAS1, activated through the #JAK2/#STAT3 signaling pathway, drives a form of cell death known as #ferroptosis in #airway cells.
https://t.co/RWnFsKGl11
Cat Oral Tumors Shrunk by STAT3 Drug, Holds Promise for Human Cancer
A novel decoy mechanism targets the once therapeutically elusive #STAT3 transcription factor and mitigates cat oral cancer in a clinical trial
@UCSF @ucdavisvetmed
#oralcancer #HNSCC
https://t.co/pTvm9BCrno
Complement and coagulation cascade cross-talk in endometriosis and the potential of Janus Kinase inhibitors—a network meta-analysis #STAT3 #MMP9 #C3 #MECFS #LongCovid
https://t.co/yHPHqgT4Pc
NR2F1 binds directly with #STAT3 promoter and upregulates the expression of p-STAT3, to facilitate the #apoptosis and migration of lens epithelial cells via the JAK1/STAT3 pathway, resulting in epithelium fibrosis and #cataracts. @CQU1929
#OpenAccess:
https://t.co/e1zQ1TKhIZ
Video Abstract📺#Parabacteroides distasonis promotes #liver #regeneration by increasing β-hydroxybutyric acid (#BHB) production and BHB-driven #STAT3 signals.
https://t.co/AZ9BIos2Io.
Silencing suppressor of cytokine signaling 3 induces apoptosis and activates the p-STAT3/NF-κB pathway in hypoxic cultivated H9c2 cells https://t.co/HSwsUxuNCV
@CQU1929 #Hypoxia #Myocardial_adaptation #Apoptosis #SOCS3 #STAT3 #NF_kB
Article✍️Targeting the #JAK2–#STAT3–#UCHL3–#ENO1 axis suppresses #glycolysis and enhances the sensitivity to #5FU #chemotherapy in #TP53-mutant #colorectal #cancer. From Dr. Wang @HebeiMedicalUniversity; @ELSpharma.
https://t.co/SFRqU70OLX.
Article✍️#Parabacteroides #distasonis promotes #liver #regeneration by increasing β-hydroxybutyric acid (#BHB) production and BHB-driven #STAT3 signals. From Dr. Bi @SouthernMedicalUniversity; @ELSpharma.
https://t.co/AZ9BIoruSQ.
🚀 Exciting research in eGastroenterology!
🔍 Discover "Protein tyrosine phosphatase delta is a STAT3-phosphatase and suppressor of metabolic liver disease", demonstrating that Ptprd deficiency promotes a phenotype of metabolic disease. #PTPRD #STAT3 #MetabolicLiverDisease
📖 Read more: https://t.co/YBbq3AwKbI
@Gut_BMJ @BMJ_Open @FrontGastro_BMJ
🚀 Don't miss this in-depth research in eGastroenterology!
🔍 Check out "Protein tyrosine phosphatase delta is a STAT3-phosphatase and suppressor of metabolic liver disease," which shows that PTPRD expression is impaired in the context of metabolic liver disease. #PTPRD #STAT3 #MetabolicLiverDisease
📖 Read more: https://t.co/YBbq3AwKbI
@Gut_BMJ @BMJ_Open @FrontGastro_BMJ
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