Top Tweets for #Wt1
Redpath et al found #WT1, the master regulator of the heart's outer layer, and its target #Sulf1, coordinate responses to incoming signals, to direct cell behavior & support heart #development. Learn more at https://t.co/HO3XQ87Pqj
@Joey_JMVieira

転移性尿路上皮癌に対するWT1経口がんワクチン B440 の第I相試験の論文が、JCO Oncology Advances に掲載されました。共著者の先生方、患者さんに深く感謝いたします。
#CancerImmunothrapy #ASCO #WT1 #UrothelialCancer #KobeUniversity
#GPS 21 MONTHS VS 5 MONTHS.
#SLS009 #Leukemia_survival 8 months over 2 months.
#Lymph_cancer using a #combo_therapy.
@SellasLife
#WT1 #1_CANCER_ANTIGEN ,
$SLS
#REMISSION
#Saftey_is_favorable. #survival_maintenance_therapy
$SLS
Everyone is focused on the 80th event.
I'm focused on what comes after.
If GPS demonstrates a strong survival benefit in Phase 3 AML, how many other WT1-positive cancers suddenly become targets?
Sometimes the biggest catalyst isn't the data.
It's what the data unlocks.
🧬🚀
Clinical #Characterization of a National Cohort of Patients With #Germline #WT1 Variants Including Late-Onset Phenotypes
#VisualAbstract by @md_abdulqader83
https://t.co/lERvg3vDlS


Further investigation in 🧒 and 🐭 showed #adrenomedullin to be common to multiple #glomerulardiseases. Other genes altered in our #WT1 #scRNAseq #glomerular dataset were unique, as was a dampened #immuneresponse, interesting in the context of steroid resistance 🤔(6/9)

These early #signalling changes were linked to impaired #endothelial #angiogeneis in culture and a loss of the #glomerular #endothelium in late disease in the 🐭, shown by @SaifNisarMalik, and in 🧒#WT1 disease samples from @kpj202, @reemy73 & Dr Olivia Boyer (4/9)

Outcome of #NPM1m #AML
⭐️ #FLT3_ITD #DNMT3A #WT1 and #non_ABD_NPM1 ⬇️ OS, ⬆️ relapse , ⬆️ MRD+
⭐️ MRD- after 2 cycles is predictive of outcome
⭐️ ⬆️ salvage flag-Ida for mrd+ ⬆️OS, ⬇️ relapse
@BloodJournal
Molecular, clinical, and therapeutic determinants of outcome in NPM1-mutated AML https://t.co/7WCsLaVfUV
Prelim safety/efficacy @CueBiopharma PhI dose-expansion of CUE-102 Immuno-STAT #IL2 immunotherapy in #WT1 positive #mCRC #GI tumors presented by @NataliyaUboha @JEvaSelfridge #ASCO24
Check out abstr # 3553
Poster Bd # 216
6/1/24 Hall A 1:30 pm CDT
https://t.co/IB0Pm7dYmf

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