Top Tweets for #adar1
🔬 新着リリース｜1,000種類以上の新規研究用分子を公開
本リリースでは、#腫瘍学 #神経科学 #免疫・炎症 #代謝疾患などの主要分野を強化し、創薬研究および基礎研究の幅広いニーズに対応します。
主な研究分野：
✔ #PROTAC による標的タンパク質分解
✔ RNA編集制御（#ADAR1）
✔ 神経炎症・自然免疫（TREM2、NLRP3）
✔ 炎症シグナル経路（PDE4B、IL-36R、LPAR1）
✔ 骨代謝制御（RANKL）
多くの化合物は、経口バイオアベイラビリティ、血液脳関門（#BBB）透過性、高い選択性、良好な薬物動態プロファイルなどの優れた特性を有し、標的検証、作用機序解析、初期創薬研究を強力にサポートします。
🔬 高品質なバイオアクティブ分子で、画期的な研究を支援します https://t.co/YH9RdGZbXM
#創薬研究 #神経炎症 #低分子化合物 #研究ツール #免疫学 #腫瘍学 #代謝研究 #ライフサイエンス #バイオテクノロジー
🔬New Releases | 1,000+ novel research molecules
Expanding #Oncology, #Neurology, #Immunology & Inflammation, and #MetabolicDisease for drug discovery and basic research. Includes #PROTACs, #ADAR1 RNA editing, neuroinflammation targets (TREM2/NLRP3), inflammatory pathways, and bone metabolism (RANKL).
🔬New Releases | 1,000+ Novel Research Molecules Now Available
This release strengthens key areas across #Oncology, #Neurology, #Immunology & #Inflammation, #MetabolicDisease, supporting a broad range of drug discovery and basic research needs.
Featured research areas include:
✔ #PROTAC-mediated targeted protein degradation
✔ RNA editing regulation (#ADAR1)
✔ Neuroinflammation & innate immunity (TREM2, NLRP3)
✔ Inflammatory signaling pathways (PDE4B, IL-36R, LPAR1)
✔ Bone metabolism regulation (RANKL)
Many of these compounds feature desirable drug-like properties, including oral bioavailability, blood–brain barrier (#BBB) penetration, high selectivity, and favorable pharmacokinetic profiles—supporting target validation, mechanistic studies, and early-stage drug discovery.
🔬Empowering breakthrough research with high-quality bioactive molecules. https://t.co/NlSVcuDiTc
#DrugDiscovery #Neuroinflammation #SmallMolecules #ResearchTools
@YunhyeKim321 & colleagues found that loss of an RNA-editing enzyme #ADAR1 in blood vessel #SMCs triggers interferon-derived immune activation that drives #PAH. Learn more at https://t.co/uoKleqogSC
@PullamsettiL @KeYuan_BCH @chansteve73
Thrilled to share our new paper 🔥out now in @MedComm_MC
We explored how the RNA-editing enzyme ADAR1 helps maintain immune balance in the gut and what happens when it fails.
The implications for ulcerative colitis are big.
#IBD #ADAR1 #GutImmunity
1/
https://t.co/u9jlGChDeT
What an end to the year! Our work is out in @NAR_Open! 🎉 We mapped #interactomes of both #ADAR1 isoforms during homeostasis & #interferon response.
Thanks to the members of MOC group (@cheriyanna) at @CEITEC_Brno and collaborators from @Varjosalo_Lab!
🔗https://t.co/QeK2mOxSGB
New preclinical research suggests that GGNBP2 mediates #autoinflammation triggered by innate immune sensing of self double-stranded RNA in the absence of #ADAR1 activity. @jacki_hf
Read more in Science #Immunology: https://t.co/Cf3wSuHwyX
🚨We are excited to share a new preprint from the BarraudLab (@EgmIbpc) and JantschLab (@MedUni_Wien) about new insights into the role of #ADAR1 dimerisation for #RNAediting.
Check it out: https://t.co/eMq6fv3Hh0
Article✍️#ADAR1 regulates #vascular #remodeling in #hypoxic# pulmonary hypertension through N1-#methyladenosine modification of #circCDK17. A novel therapeutic strategy for #PH & circCDK17 as a potential novel #marker. From Dr. Nie @jinanuniversity;
https://t.co/mh4OuuUn7u
🔬 #ADAR1 inhibits macrophage apoptosis, easing sepsis-induced liver injury via miR-122/BCL2A1 signaling. Dr. Shanshou Liu et al. illuminate this vital connection.
Read more: 🔓 https://t.co/ysMuAXboq3
👥 @ccpox @SepsisUK @LiverNotFighter @LiverEmpire
Novel insights into double-stranded RNA-mediated immunopathology https://t.co/IV5JyDLa3D
Are you excited about #innateimmunity #nucleicacidsensing #interferons #ADAR1 #ncRNA #viralinfection #reproductiveimmunology? Want to live & work in Leiden? We’re recruiting a PhD student or post-doc for our team @LUMC_Leiden @GlobalLumc 🥳 🧬🦠🧫🥼👩🏻🔬🔬🇳🇱
Please RT far & wide!
Congratulations to the Walkley lab on publication of this exciting #ADAR1 and #RNA editing in #cancer research!
Congratulations to Carl, @jacki_hf, Ankitaka Goradia, @AlistairChalk and 1st author/former Masters student, Shannon Mendez Ruiz👏👏
Great to have this work studying the in vivo role of #ADAR1 and #RNAediting in #cancer from the Walkley lab out in NAR Cancer! Full tweetorial in the thread below.
@NAR_Cancer_EIC @SVIResearch @AlistairChalk @UniMelbMDHS
https://t.co/0jENVVA8Kn
Great to have this work studying the in vivo role of #ADAR1 and #RNAediting in #cancer from the Walkley lab out in NAR Cancer! Full tweetorial in the thread below.
@NAR_Cancer_EIC @SVIResearch @AlistairChalk @UniMelbMDHS
https://t.co/0jENVVA8Kn
Happy to share the new preprint from the Walkley lab where we directly tested whether increasing levels of #ADAR1 and A-to-I editing levels in vivo could promote #cancer formation or progression. (1/n)
@SVIResearch @AlistairChalk
https://t.co/ZHtrthVa7v
Our recent study investigates the role of #ADAR1 #RNAediting during B cell lymphomagenesis.
A big thank you to @PapaStebLabs for the usual support and to @panhammarstrom for the great collaboration.
Thanks also to @TheBinderLab and Dominic Helm for their fantastic help
Our new study suggests that RNA editing may represent a mechanism complementary to that of DNA mutation in B cell lymphomagenesis https://t.co/Ua39QRs2nL
If you're at the 2023 @GordonConf on RNA Editing this week, you won't want to miss our poster "Discovery of Small Molecule Inhibitors of #ADAR1"!
Read @TrendsImmuno March issue! #HIV reservoirs, flagellin& #tolerance, #TLR9 & #lupus, #RIPK1, tumor #gdTcells, #PGE2 & #autoimmunity, #COVID19 &Africa, oxidized #mtDNA, #ADAR1 & #innate immunity, #nutrient deficiency&obesity&immunity, #metabolism &Tcells https://t.co/pZdeTFXvTU
In this issue of @CircRes Cai & colleagues generated a humanized #AAA model and demonstrated #ADAR1 is induced in #macrophages and contributes to AAA development. Learn more at https://t.co/kO4IQL8pYK
Our new Clinical & Translational Report is out @CellStemCell! Our stellar team in the Jamieson Lab @UCSanDiegoDRM blocked #ADAR1 in pre-cancer #myelofibrosis #stemcells and #AML with Rebecsinib, a potent #RNAsplicing modulator.
https://t.co/ErPuk0s08Q
@CellPressNews @UCSDHealth
This a great review for the researcher working in the field of innate immunity, cell death, and disease. Congratulations @rajukarki16 @ThiruKanneganti #innateimmunity #celldeath #disease #ADAR1 #ZBP1
https://t.co/N6lTwEGhaa
Congrats @jacki_hf, Carl Walkley & members of his Cancer & RNA Biology team-former Masters student/1st author Shannon Mendez Ruiz, @AlistairChalk & Ankita Goradia-on another #ADAR1 paper: Over-expression of ADAR1 in mice does not initiate or accelerate cancer formation in vivo.
Happy to share the new preprint from the Walkley lab where we directly tested whether increasing levels of #ADAR1 and A-to-I editing levels in vivo could promote #cancer formation or progression. (1/n)
@SVIResearch @AlistairChalk
https://t.co/ZHtrthVa7v
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