Top Tweets for #aimmhighlights
New article out now #AIMMhighlights
▶️ ZEB1 was strongly expressed in renal oncocytoma but absent in chromophobe RCC
▶️ CK7 showed the opposite staining pattern
▶️ Combined ZEB1 + CK7 assessment achieved 95.5% diagnostic accuracy
Complementary Diagnostic Value of ZEB1 and CK7 in Renal Oncocytoma and Chromophobe Renal Cell Carcinoma https://t.co/c71PauXgfK
New article out now #AIMMhighlights
▶️ Punctate MLH1 staining with VENTANA M1 can mimic retained expression
▶️ Alternate clone confirmed MLH1 loss in all 11 dMMR cases
▶️ Recognize this pitfall: 4/11 cases were initially misread as MMR-proficient
Punctate Nuclear MLH1 Staining With the VENTANA M1 Clone in Colorectal Carcinoma: Identification of 3 Patterns in Matched Biopsy-Resection Specimens https://t.co/MJnDeGRL9i
New article out now #AIMMhighlights
▶️ Faint HER2 staining can determine T-DXd eligibility
▶️ 89 studies: 0 vs 1+ agreement remains weakest (κ/ICC 0.41–0.69)
▶️ Null vs ultralow: only 10 studies; κ as low as 0.09
▶️ Evidence too fragmented to pool—the gap itself is a key finding
Interobserver Reproducibility of Treatment-Defining HER2-Low and HER2-Ultralow Immunohistochemical Scoring in Breast Carcinoma: A Systematic Review https://t.co/R8WL04ZCnT
New article out now #AIMMhighlights
▶️ Pretreatment biopsy IHC may help assess neoadjuvant response in rectal cancer
▶️ Higher Beclin-1 linked to poorer pathologic response and treatment resistance
▶️ Low eIF2α associated with shorter overall survival
Autophagy- and Stress-Related Biomarkers in Pretreatment Rectal Adenocarcinoma Biopsies: Associations With Pathologic Response to Neoadjuvant Therapy and Survival https://t.co/P0qjG3c1Xu
New article out now #AIMMhighlights
▶️ Main groups: biphasic, monophasic glandular, monophasic squamoid, oncocytic
▶️ Suggested initial stains: p40, CD117, S100
▶️ Correlate biopsy to resection to support diagnostic accuracy and active learning @nicolecipriani
Algorithmic Approach to Diagnosis of Salivary Gland Neoplasms Based on Morphology and Select Immunostains https://t.co/iBIzhyzrAR
New article out now #AIMMhighlights
▶️ Some RTU antibodies underperformed with vendor-recommended protocols
▶️ Dako Omnis: 58/62 (94%) rated optimal/good
▶️ BenchMark Ultra Plus: 37/63 (59%) rated optimal/good
▶️ Thorough validation remains essential before diagnostic use
Immunohistochemistry Assay Based on Ready-To-Use Antibodies and Vendor-Recommended Protocol Settings Often Perform Suboptimally https://t.co/MuhVicuEEB
New article out now #AIMMhighlights
▶️ LBP4 shows 93.7% concordance with SP44 for c-MET IHC in NSCLC
▶️ LBP4 + Ultraview offers a lower-cost alternative to Optiview
▶️ c-MET IHC 2+/3+ predicts OS benefit with savolitinib (P=0.0035)
A Single-Center Comparative Study of the c-MET Immunohistochemistry SP44 and LBP4 Assays in Chinese Non-Small Cell Lung Cancer (NSCLC) Cohort https://t.co/2dcaMKNCxN
New article out now #AIMMhighlights
▶️ Esophageal ADC expresses GATA6; SCC expresses GATA3 and GATA6
▶️ GATA3 may be a useful negative marker for esophageal ADC in metastatic workups
▶️ GATA6 may be associated with poor prognosis @hebammassoud
Differential Immunohistochemical Expression of GATA6 and GATA3 in Esophageal Carcinoma: Correlation With Clinicopathologic Parameters and Patients’ Survival https://t.co/Nu6NId87mm
New article out now #AIMMhighlights
▶️ Aggressive CD34+ spindle cell sarcoma misdiagnosed as synovial sarcoma/FS-DFSP
▶️ Rapid progression despite chemotherapy required amputation
▶️ Pan-TRK IHC + NGS identified TPM3::NTRK1 fusion
▶️ Supports routine molecular confirmation
A High-Grade CD34-Positive Spindle Cell Sarcoma of the Palm Revealing an Unexpected TPM3::NTRK1 Fusion: A Diagnostic Pitfall With Major Therapeutic Implications https://t.co/nv850dPmgO
New article out now #AIMMhighlights
▶️ Golgi-pattern PDGFRA staining correlates with PDGFRA-mutant GISTs
▶️ Gastric epithelioid/mixed GISTs with reduced KIT often have PDGFRA mutations
▶️ PDGFRA IHC shows high sensitivity
▶️ Molecular testing remains the gold standard @DrRolaAli
Golgi-Pattern PDGFRA Immunoreactivity Correlates With PDGFRA Mutation Status in Gastric Epithelioid and Mixed-Type Gastrointestinal Stromal Tumors https://t.co/oDCWl5woOw
New article out now #AIMMhighlights
▶️ LRRC15 absent in normal bile ducts; expressed in distal bile duct carcinoma
▶️ LRRC15 expression stronger in stroma than tumor cells; assoc with pancreatic invasion and poor survival
▶️ Tumor+/stroma+ expression predicts the worst prognosis
Clinicopathological Significance of Leucine-rich Repeat-containing 15 in Distal Extrahepatic Bile Duct Carcinoma https://t.co/qywsbyz7GN
New article out now #AIMMhighlights
▶️ Links alcohol use with higher TP53 mutation rates in uterine endometrioid carcinoma
▶️ TP53 and ARID1A may serve as prognostic biomarkers
▶️ Adds evidence for gene–environment interactions in endometrial cancer @yaseminadali01
Prognostic Role of TP53 and ARID1A Mutations in Alcohol-Consuming Patients With Uterine Endometrioid Carcinoma https://t.co/2HSDngA2qX
New article out now #AIMMhighlights
▶️ APAFIX™ (formalin-free) vs 10% formalin in human biopsies
▶️ Preserved tissue morphology & processing quality, improved nuclear detail & lymphocyte visualization
▶️ Supports APAFIX™ as a promising alternative for routine tissue fixation
Comparative Evaluation of APAFIX and 10% Formalin for Human Histologic Tissue Preservation: A Pilot Study https://t.co/xLOemxlV4L
New article out now #AIMMhighlights
▶️CD30 and Cyclin D1: 100% positive and OCT2: 90% positive in RDD
▶️ Helpful IHC panel for distinguishing RDD from LCH, IMT & IgG4-RD
Clinicopathological Features and Expression of CD30, OCT2, and Cyclin D1 in Rosai-Dorfman Disease: A Retrospective Case Series https://t.co/rzfLWBk9BO
New article out now #AIMMhighlights
▶️ HER2 DISH closely matched FISH
▶️ Discordance mainly in borderline amplified tumors
▶️ Differences clustered near the 2.0 HER2/CEP17 cutoff
▶️ Supports DISH as a robust routine testing method
HER2 In Situ Hybridization: Validation and Implementation of Brightfield Assay in a US Academic Pathology Laboratory https://t.co/asQ8fAwluf
New article out now #AIMMhighlights
Rare keratoameloblastoma: ✌🏻cases revealing unique keratinizing features, low Ki-67 index, and a cytokeratin profile overlapping with ameloblastoma and odontogenic keratocyst
Keratoameloblastoma of the Jaw Bones: Description of 2 Rare Cases and Cytokeratin Profile https://t.co/4d4YB2aazh
New article out now #AIMMhighlights
▶️ Rare RCC with concurrent SMARCB1(INI-1) and FH loss
▶️ FH loss by IHC does not always indicate FH-mutated RCC
▶️ Possible epigenetic FH suppression from SMARCB1 alteration
▶️ Molecular testing remains critical for diagnosis and therapy
Renal Cell Carcinoma With Concurrent Loss of SMARCB1/INI-1 and Fumarate Hydratase By Immunohistochemistry: A Case Report With Review of the Literature https://t.co/4avxaPGGkK
Check out this article #AIMMhighlights
▶️ Loss-based IHC (SDHB, H3K27me3) sensitive to protocol/platform
▶️ Optimize sensitivity vs specificity; heterogeneity is challenging
▶️ Same antibody, different results: ↓ staining on Ventana Ultra (left) vs strong on BOND III (right)
Technical Challenges Faced in Validation of Immunohistochemical Assays That Test for Loss of Protein Expression—Case Studies in Succinate Dehydrogenase B and H3K27ME3 https://t.co/wAYb1lMav6
New article out now #AIMMhighlights
▶️ SHH regulates ectomesenchyme
▶️ BMP4 high in odontoma ectomesenchyme
▶️ SHH high in tooth germ epithelium and odontomas
▶️ SHH in odontoma ectomesenchyme and inner enamel epithelium
▶️ SHH and BMP4 correlate in bud/cap stages
Interrelationship Between SHH and TGF-beta in the Formation of Odontomas https://t.co/4qAiMOdIzw
New article out now #AIMMhighlights
▶️ Sponge vertical embedding improves slide quality
▶️ Reduces tissue curling vs conventional methods
▶️ Ensures accurate orientation for diagnosis
▶️ Simple and fast for technicians
A Tissue Processing Technique for Improving Slide Preparation Quality of ESD Specimens https://t.co/IWIXIgwQFC
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