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over 1 year ago

🇨🇳 #ASCO2025 #DualityBio reported preliminary results form Ph1/2a trial of #DB1310, a #HER3-targeted #ADC, in pts with advanced solid tumors. https://t.co/ML8gdUR6cz DB-1310 is a novel ADC comprised of a humanized anti-HER3 IgG1 monoclonal antibody, cleavable peptide linker, and DNA topoisomerase I inhibitor. The unconfirmed ORR was 25.5% (95% CI, 17.63, 34.65) across all tumor types and 35.7% (95% CI, 21.55, 51.97) in EGFRm NSCLC. Median PFS was 5.4 months overall and 7.0 months for EGFRm NSCLC.

chuminhua432's tweet photo. 🇨🇳 #ASCO2025 #DualityBio reported preliminary results form Ph1/2a trial of #DB1310, a #HER3-targeted #ADC, in pts with advanced solid tumors. https://t.co/ML8gdUR6cz

DB-1310 is a novel ADC comprised of a humanized anti-HER3 IgG1 monoclonal antibody, cleavable peptide linker, and DNA topoisomerase I inhibitor.

The unconfirmed ORR was 25.5% (95% CI, 17.63, 34.65) across all tumor types and 35.7% (95% CI, 21.55, 51.97) in EGFRm NSCLC. Median PFS was 5.4 months overall and 7.0 months for EGFRm NSCLC.

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