Top Tweets for #hrev
Despite GDMT, many patients with HFrEF remain symptomatic. Direct cardiac microcurrent (C-MIC) therapy may promote reverse remodeling and improve outcomes, but larger sham-controlled trials are needed before
adoption (https://t.co/xbyzg4tpsN). #HREV @FudimMarat @JavedButler1
Ischemic cardiomyopathy remains a leading cause of HF and CV death. This review highlights the evolving role of imaging, viability, and revascularization, while reinforcing GDMT and device therapy as the foundation (https://t.co/AzWtCLBga9). #HREV @GianluSava @NicolasGirerd
Congestion is the main driver of recurrent HF. This review explores the biology of congestion and emerging multimodal strategies—including US, biomarkers, and invasive hemodynamics—for earlier and more precise detection across HF phenotypes (https://t.co/MT35bA4Pkk). #HREV
HF significantly impacts QoL & employment. In a scoping review (47 studies; n=64K), return to work (RTW) rates were highly variable (median ~56%) with no consistent definition. RTW is shaped by many factors—clear definitions & support are needed (https://t.co/GU5DxoaMgs). #HREV
CS remains a major challenge—high mortality, no standard therapy. This review highlights ongoing trials across 3 key strategies: novel drugs, optimized MCS, and advanced hemodynamic monitoring—pointing toward future directions to improve outcomes (https://t.co/kk4NmBdcId). #HREV
The inaugural #CALShock meeting highlighted gaps in U.S. cardiogenic shock systems—and a scalable path forward: standardized classification, streamlined shock team activation, optimized MCS use, and coordinated transfer networks (https://t.co/VzURDPWGDF). #HREV @ConnorObrienMD
Vocal biomarkers are emerging as a scalable tool for HF screening, risk stratification, and monitoring. Signals like pause ratio and phonation metrics—powered by AI—can detect HF and predict hospitalization/mortality. (https://t.co/sTJIhzCLWx). #HREV
U-CARS 2026 highlights: refined β-adrenergic signaling enabling more targeted β-blocker strategies, intercellular crosstalk driving remodeling, and HF as a multisystem (cardio-renal-metabolic) syndrome—pointing toward integrated, precision therapy (https://t.co/ew0YUCjjqr). #HREV
Obesity-related HFpEF is a multiorgan syndrome driven by inflammation, hemodynamic load, and ectopic fat. Incretin therapies (GLP-1 ± GIP) improve symptoms, function, and HF events while reducing organ fat—promising strategy for a tough phenotype (https://t.co/tVzSnrsg2F). #HREV
More data on the clinical effects of ARNI in Chagas’ disease: ANSWER-HF mirrored the findings observed in the larger PARACHUTE-HF —> reduced NT-proBNP and numerically (not powered for events) lower HF hospitalizations and cardiovascular death. Read our mini-review in #HREV⤵️
Chagas CM remains a major driver of HF morbidity/mortality with limited data to guide therapy.
In PARACHUTE-HF, sacubitril/valsartan outperformed enalapril—improving outcomes, driven by reductions in natriuretic peptides (https://t.co/trbBBXe0Lz). #HREV @PatriciaGuimMD @pmyhre
Up to 50% of deaths in HFrEF are sudden—but LVEF alone is a poor risk stratifier.
High-risk signals: syncope, CKD, VT, ↓ GLS, myocardial fibrosis.
Future = multimodal risk models + precision ICD decisions—not LVEF alone
(https://t.co/dH38CelzIL). #HREV @AHajduczok
Chagas CM remains a major driver of HF morbidity/mortality with limited data to guide therapy.
In PARACHUTE-HF, sacubitril/valsartan outperformed enalapril—improving outcomes, driven by reductions in natriuretic peptides (https://t.co/trbBBXe0Lz). #HREV @PatriciaGuimMD @pmyhre
CCM offers a device-based option for HFrEF patients not eligible for CRT—improving QoL, exercise capacity, and LV function. Mechanistically: calcium handling + reverse remodeling. Next step: better patient selection + CVOTs for hard outcomes (https://t.co/2dHiqITicO). #HREV
Restrictive CM is rare but often missed. Infiltrative causes (amyloid, sarcoid, iron) share HF + arrhythmias—but have distinct “red flags.” Multimodality imaging: echo → physiology, CMR → tissue, nuclear → diagnosis/monitoring. Recognize early (https://t.co/T7QSphQMaV)! #HREV
HFpEF is rising and as deadly as HFrEF—but defining it is inconsistent. Heterogeneity + variable trial criteria = missed signals. Future success depends on better phenotyping, standardized definitions, and aligning trials with underlying biology (https://t.co/T7RO2kHE9m). #HREV
Temporary MCS has transformed CS. IABP, Impella, and ECLS offer hemodynamic support as bridges to recovery, escalation, or transplant. Comparison and practical algorithm for device selection, escalation/de-escalation, and antithrombotic management (https://t.co/kt8LAcFjI9). #HREV
From Charleston HFpEF: refining phenotypes with invasive hemodynamics, recognizing preclinical disease, and targeting CKM risk. nsMRAs/GLP-1 RAs, RPM, and emerging device/pharmacotherapy for PH highlight where the field is headed (https://t.co/hp8l0YmHwm). #HREV @RyanTedfordMD
Beta-blockers have been SoC post-MI, but much of the evidence comes from the pre-reperfusion era and their role—especially in preserved EF—is less clear. Emerging data support a tailored approach based on EF, comorbidities, arrhythmias, and QoL (https://t.co/06ewkZyqpP). #HREV
Obstructive HCM is shifting from symptomatic treatment to disease modification. Myosin inhibitors reduce LVOT gradients and improve exercise capacity and QoL. Key questions remain: long-term safety, sequencing, and patient selection (https://t.co/GJGOB5qCfV). Read now in #HREV
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